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2006年7月例会 ・一般講演 1. 食餌制限ラットにおける下顎骨・脛骨骨密度の加齢変化と修飾要因 5. Histopathology of inner ear in the joggle mutant mouse and its gene mapping on chromosome 6 6. 沖縄で発見されたアルビノ様野生スンクスの遺伝様式と系統育成 7. 癌型Rasとp53機能喪失にの協調による多形型横紋筋肉腫の発生 8. 中枢神経,神経提細胞特異的な癌型N-Ras発現による神経線維腫症病態モデルマウスの作製 9. Pur-1遺伝子領域を導入したコンジェニックラットにおける蛋白尿発症 11. ヒメコミミトガリネズミCryptotis parvaの米国からの導入―齧歯目・ウサギ目以外の哺乳類の輸入とその経緯― |
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5. Histopathology of inner ear in the joggle mutant mouse and its gene mapping on chromosome 6 |
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陳 自艶1, 早坂 静2, 高岸 芳子2, 村田 善晴2, 織田 銑一1 The joggle mutant mouse exhibits abnormal behaviors such as a hesitant and joggle-like gait. In addition, we found they show no startle response to sounds and an inability to swim. These clinical traits are controlled by a single autosomal recessive gene. In this study, the histopathological findings of severe damage in inner ears of homozygotes have been demonstrated. And we develop a rapid and simple gene mapping method using the congenic joggle mouse strain. We map the mutant gene to the nearby markers D6Mit104 and D6Mit336. From the mouse genomic sequence database, we can estimate this region is located around 11Mb between 114.4Mb and 125.14Mb on chromosome 6. |
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