1. Kato A, Kondo N, Wanifuchi-Endo Y, Fujita T, Asano T, Hisada T, Uemoto Y, Terada M, Toyama T. High Tinagl1 expression is a marker of good prognosis in breast cancer. 2021 San Antonio Breast Cancer Symposium(SABCS), Dec7-10, 2021 (San Antonio/Virtual)
2. Uemoto Y, Kondo N, Wanifuchi-Endo Y, Asano T, Hisada T, Nishikawa S, Katagiri Y, Kato A, Terada M, Toyama T. Sentinel lymph node biopsy may be unnecessary for ductal carcinoma in situ of the breast that is small and diagnosed by preoperative biopsy. 10th Global Breast Cancer Conference(GBCC10) Apr8-10, 2021(Seoul/Virtual)
3. Tatsuya Toyama, Yutaka Yamamoto, Hiroji Iwata, Masato Takahashi,Tetsuhiro Yoshinami, Takayuki Ueno,Takashi Yamanaka, Toshimi Takano, Masahiro Kashiwaba, Norikazu Masuda, Koichiro Tsugawa, Yoshie Hasegawa, Kenji Tamura, Hiroshi Tada, Naruto Taira, Fumikata Hara, Shigehira Saji, Satoshi Morita, Masakazu Toi, Shinji Ohno, on behalf of the PRECIOUS Study Group.PRECIOUS: Pertuzumab re-treatment for HER2-positive locally advanced/metastatic breast cancer (JBCRG-M05). 【Presidential Session】第18回日本臨床腫瘍学会学術集会、2021年2月18-20日(京都・WEB)
4. Uemoto Y, Katsuta E, Kondo N, Wanifuchi Y, Fujita T, Asano T, Hisada T, Terada M, Kato A, Sugiura H, Kato H, Takahashi S, Toyama T. Low expression of HECTD1 is a poor prognostic marker of breast cancer by promoting mitochondrial cell respiration. 【英語口演】第18回日本臨床腫瘍学会学術集会、2021年2月18-20日(京都・WEB)
2020
1. Ian Krop, Kan Yonemori, Shunji Takahashi, Kenichi Inoue, Takahiro Nakayama, Hiroji Iwata, Tatsuya Toyama, Yutaka Yamamoto, Masato Takahashi, Akihiko Osaki, Shigehira Saji, Yasuaki Sagara, Joyce O’Shaughnessy, Tiffany Traina, Shoichi Ohwada, Zhenhao Qi, Yang Qiu, Hiroshi Onuma, Om Sharma, Sabeen F. Mekan, Norikazu Masuda. Safety and Efficacy Results From the Phase 1/2 Study of U3-1402, a Human Epidermal Growth Factor Receptor 3 (HER3)-Directed Antibody Drug Conjugate (ADC), in Patients With HER3-Expressing Metastatic Breast Cancer (MBC), 2020 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 10, 2020
2. Yutaka Yamamoto, Hiroji Iwata, Naruto Taira, Norikazu Masuda, Masato Takahashi, Tetsuhiro Yoshinami, Takayuki Ueno, Tatsuya Toyama, Takashi Yamanaka, Toshimi Takano, Masahiro Kashiwaba, Koichiro Tsugawa, Yoshie Hasegawa, Kenji Tamura, Hiroshi Tada, Fumikata Hara, Shigehira Saji, Satoshi Morita, Masakazu Toi, Shinji Ohno, A randomized, open-label, phase III trial of pertuzumab re-treatment in HER2-positive, locally advanced/metastatic breast cancer patients previously treated with pertuzumab, trastuzumab, and chemotherapy: The Japan Breast Cancer Research Group-M05 (PRECIOUS) study. 2020 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 10, 2020
2019
1. Yasuaki Uemoto, Naoto Kondo, Yumi Wanifuchi-Endo, Tomoko Asano, Tomoka Hisada, Sayaka Nishikawa, Yusuke Katagiri, Mitsuo Terada, Akiko Kato, Yu Dong, Hiroyuki Kato, Satoru Takahashi, Tatsuya Toyama. The prognostic impact of HECTD1 E3 ubiquitin ligase expression in breast cancer patients. 2019 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 10-14, 2019
2. Tomoka Hisada, Naoto Kondo, Yumi Wanifuchi-Endo, Tomoko Asano,Yasuaki Uemoto, Nishikawa Sayaka, Yusuke Katagiri, Mitsuo Terada, Akiko Kato, Yu Dong, Hiroyuki Kato, Satoru Takahashi, Tatsuya Toyama. LLGL2 is involved in resistance to tamoxifen in ERα-positive breast cancer patients. 2019 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 10-14, 2019.
3. Shigehira Saji, Masahiro Kitada, Toshimi Takano, Masahiro Takada, Tohru Ohtake, Tatsuya Toyama, Yuichiro Kikawa, Yoshie Hasegawa, Tomomi Fujisawa, Masahiro Kashiwaba, Takanori Ishida, Rikiya Nakamura, Yutaka Yamamoto, Uhi Toh, Hiroji Iwata, Norikazu Masuda, Naruto Taira, Satoshi Morita, Shinji Ohno, Masakazu Toi. A randomized, multicenter, phase II study evaluating the efficacy of interventional maintenance endocrine therapy with Bevacizumab following fixed cycles of Bevacizumab plus Paclitaxel in advanced/metastatic ER-positive HER2-negative breast cancer: JBCRG-M04 BOOSTER trial. 2019 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 10-14, 2019.
4. Ian Krop, Norikazu Masuda, Takahiro Kogawa, Shunji Takahashi, Kan Yonemori, Kenichi Inoue, Takahiro Nakayama, Yutaka Yamamoto, Ricardo Alvarez, Tatsuya Toyama, Akihiko Osaki, Masato Takahashi, Joyce O'Shaughnessy, Yasuaki Sagara, Shigehira Saji, Virginia Kaklamani, Sun Young Oh, William Gradishar, Barbara Haley, Tsutomu Iwasa, Tiffany Traina, Naoto Ueno, Yoshimi Tanaka, Sabeen Mekan, Hiroshi Onuma, Hiroji Iwata. Phase 1/2 first-in-human study of U3-1402, an anti-human epidermal growth factor receptor 3 (HER3) antibody-drug conjugate, in HER3-overexpressing advanced/unresectable or metastatic breast cancer. 2019 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 10-14, 2019.
5. Kashiwaba M, Sawaki M, Saito T, Kobayashi K, Kawashima H, Tsuneizumi M, Sagawa N, Bando H, Takahashi M, Yamaguchi M, Takashima T, Nakayama T, Baba S, Mizuno T, Yamamoto Y, Taira N, Iwata H, Toyama T, Tsugawa K, Ohashi Y, Mukai H. A Cohort Study to Evaluate the Efficacy and Safety of Postoperative Adjuvant Therapy in HER2-Positive Elderly Breast Cancer Patients (RESPECT-Cohort study). 2019 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 10-14, 2019.
6. Kan Yonemori, Norikazu Masuda, Shuji Takahashi, Takahiro Kogawa, Takahiro Nakayama, Hirotaka Iwase, Masato Takahashi, Tatsuya Toyama, Toshiaki Saeki, Shigehira Saji, Kenichi Inoue, Hiroshi Onuma, Naoyuki Tajima, Yoshinobu Shiose, Shuquan Chen, Ferdinand Guevara, Channing Yu, Suguru Ueno, Hiroji Iwata. Single Agent Activity of U3-1402, a HER3-Targeting Antibody-Drug Conjugate, in HER3 Overexpressing Metastatic Breast Cancer: Updated Results from a Phase 1/2 Trial. ESMO Breast Cancer 2019 (Berlin, Germany), 2-4 May 2019.
7. Kazutaka Narui, Norikazu Masuda, Yutaka Yamamoto, Tomomi Fujisawa, Tatsuya Toyama, Masahiro Kashiwaba, Shoichiro Ohtani, Naruto Taira, Takehiko Sakai, Yoshie Hasegawa, Rikiya Nakamura, Hiromitsu Akabane, Yukiko Shibahara, Hironobu Sasano, Debbie M. Jakubowski, Anna Lau, Naoko Sugiyama, Calvin Chao, Hiroji Iwata. Lack of concordance between Ki67 labeling index and 21-gene Breast Recurrence Score® test results in patients with ER+, HER2−, clinically node-negative breast cancer: A secondary analysis of TransNEOS neoadjuvant study. St.Gallen International Breast Cancer Conference (Vienna /Austria) 20 - 23 Mar 2019.
8. 遠山竜也、近藤直人、鰐渕友美、久田知可、西川さや香、上本康明、片桐悠介、寺田満雄、加藤明子. The strategy to overcome the endocrine resistance in hormone receptor-positive breast cancer(シンポジウム). 第57回日本癌治療学会学術集会 2019年10月24日-26日(福岡)
2018
1. Sayaka Nishikawa, Naoto Kondo, Yumi Wanifuchi-Endo, Tomoka Hisada, Yasuaki Uemoto, Yusuke Katagiri, Yu Dong, Hiroyuki Kato, Satoru Takahashi, Tatsuya Toyama. The prognostic impact of synaptojanin 2 expression in estrogen receptor α-positive breast cancer patients. 2018 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 4-8, 2018.
2. Toshinari Yamashita, Masaya Hattori, Takumi Nakada, Takako Hayashi, Keitaro Kamei, Tatsuya Toyama, Yasuko Nagao, Takahiro Mase, Masaki Wada, Toshiro Mizuno, Kojiro Shimozuma, Hiroji Iwata, Takuhiro Yamaguchi. Subjective and objective assessment of efficacy of frozen gloves and socks to prevent nab-paclitaxel-induced peripheral neuropathy in patients with breast cancer. 2018 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 4-8, 2018.
3. Norikazu Masuda, Kan Yonemori, Shuji Takahashi, Takahiro Kogawa, Takahiro Nakayama, Hirotaka Iwase, Masato Takahashi, Tatsuya Toyama, Toshiaki Saeki, Shigehira Saji, Kenichi Inoue, Hiroshi Onuma, Naoyuki Tajima, Yoshinobu Shiose, Shuquan Chen, Ferdinand Guevara,Channing Yu, Suguru Ueno, Hiroji Iwata. Single Agent Activity of U3-1402, a HER3-Targeting Antibody-Drug Conjugate, in HER3-Overexpressing Metastatic Breast Cancer: Updated Results of a Phase 1/2 Trial. 2018 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 4-8, 2018.
4. Hiroji Iwata, Takehiko Sakai, Yoshie Hasegawa, Rikiya Nakamura, Hiromitsu Akabane, Shoichiro Ohtani, Masahiro Kashiwaba, Naruto Taira, Tatsuya Toyama, Yutaka Yamamoto, Tomomi Fujisawa, Norikazu Masuda, Yukiko Shibahara, Hiroshi Sasano, Takuhiro Yamaguchi, Yasuo Ohashi. Distant disease-free survival (DDFS) according to response category in neoadjuvant endocrine therapy (NET): 6-Year analysis in phase III NEOS trial. ESMO (European Society for Medical Oncology) 2018 Congress, Oct 19-23, 2018. Munich, Germany.
5. Norikazu Masuda, Shinzaburo Noguchi, Takashi Ishikawa, Tomoyuki Aruga, Seung Jin Kim, Tatsuya Toyama, Toshiaki Saeki, Mitsue Saito, Takashi Yamanaka, Junichiro Watanabe, Seigo Nakamura, Masato Takahashi, Kenichi Inoue, Ioannis Gounaris, Yu Han, Tanay S. Samant, Mihaela Gazdoiu, Yoshinori Ito. MONALEESASIA: Ribociclib + Endocrine Therapy in Japanese Women With Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer. ESMO (European Society for Medical Oncology)-Asia 2018 Congress, Nov. 23-25, 2018 (Singapore, Singapore)
6. Yoon-Sim Yap, Norikazu Masuda, Yoshinori Ito, Takashi Ishikawa, Seung Jin Kim, Tomoyuki Aruga, Tatsuya Toyama, Toshiaki Saeki, Takashi Yamanaka, Mitsue Saito, Junichiro Watanabe, Masato Takahashi, Seigo Nakamura, Kenichi Inoue, Jose Suarez-Vizcarra, Wei He, Nadia Solovieff, Faye Su, Joanne Chiu. Biomarker analyses of Asian women with hormone receptor-positive (HR+), HER2-negative (HER2–) advanced breast cancer (ABC) receiving ribociclib (RIB) + endocrine therapy (ET). Mini-Oral presentation. ESMO (European Society for Medical Oncology)-Asia 2018 Congress, Nov. 23-25, 2018 (Singapore, Singapore)
7. Takahiro Kogawa, Kan Yonemori, Norikazu Masuda, Shunji Takahashi, Masato Takahashi, Hirotaka Iwase, Takahiro Nakayama, Toshiaki Saeki, Tatsuya Toyama, Toshimi Takano, Hiroshi Onuma, Hayao Ogawa, Yoshimi Tanaka, Yoshiko Igari, Masahiro Sugihara, Michele Vigliotti, Channing Yu, Martin Olivo, Suguru Ueno, Hiroji Iwata. Single-Agent Activity of U3-1402, a HER3-Targeting Antibody-Drug Conjugate, in Breast Cancer Patients: Phase 1 Dose Escalation Study. The 53th Annual meeting of American Society of Clinical Oncology (ASCO), June 1-5, 2018 (Chicago, IL, USA).
2017
Nishikawa S, Kondo N, Endo Y, Hato Y, Hisada T, Nishimoto M, Dong Y, Okuda K, Kato H, Takahashi S, Nakanishi R, Toyama T. The prognostic impact of Retinoic Acid-Induced 2(RAI2) expression in ERα-positive breast cancer patients. 2017 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 5-9, 2017.
Iwata H, Yamamoto Y, Sakai T, Hasegawa Y, Nakamura R, Akabane H, Ohtani S, Kashiwaba M, Taira N, Toyama T, Fujisawa T, Masuda N, Shibahara Y, Sasano H, Yamaguchi T, Ohashi Y. NEOS: A randomized, open label, phase 3 trial of adjuvant chemotherapy for postmenopausal breast cancer patients who responded to neoadjuvant letrozole: First report of long-term outcome and prognostic value of response to neoadjuvant endocrine therapy. 2017 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 5-9, 2017.
Yamamoto Y, Iwata H, Masuda N, Fujisawa T, Toyama T, Kashiwaba M, Ohtani S, Taira N, Sakai T, Hasegawa Y, Nakamura R, Akabane H, Shibahara Y, Sasano H, Yamaguchi T, Sakamaki K, Chao C, McCullough D, Sugiyama N, Ohashi Y. TransNEOS: Validation of the Oncotype DX Recurrence Score testing core needle biopsy samples from NEOS as predictor of clinical response to neoadjuvant endocrine therapy for postmenopausal ER+, HER2-negative breast cancer patients. 2017 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 5-9, 2017.
Toyama T, Jeong J, Srimuninnimit V, Sriuranpong V, Noh W, Tsugawa K, Takahashi M, Iwase H, Arce C, Ridolfi A, Lin C, Royce M, Cardoso F. Everolimus (EVE) + letrozole (LET) in patients (pts) with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2−) advanced breast cancer (ABC): subgroup analysis of first line (1L) progression-free survival (PFS) by race from the BOLERO-4 study. ESMO (European Society for Medical Oncology)-Asia2017 Congress, Nov. 17-19, 2017 (Singapore, Singapore): Proffered Paper (Oral)
Cardoso F, Villanueva C, Royce M, Cruz FM, Debled M, Hegg R, Toyama T, Falkson C, Jeong J, Srimuninnimit V, Ozguroglu M, Gradishar WJ, Azevedo SJ, Arce C, Ridolfi A, Lin C, Bachelot T. Everolimus (EVE) plus endocrine therapy in patients with estrogen receptor–positive (ER+), human epidermal growth factor receptor 2–negative (HER2−) advanced breast cancer (BC): first and second-line data from the BOLERO-4 study. The 52th Annual meeting of American Society of Clinical Oncology (ASCO), June 2-6, 2017 (Chicago, IL, USA).
Kondo N, Kim T-S, Endo Y, Hato Y, Hisada T, Nishimoto M, Nishikawa S, Toyama T. The prognostic impact of Inositol polyphosphate 5-phosphatase PIPP (INPP5J) expression in breast cancer tissue. 2016 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 6-10, 2016.
Villanueva C, Tsugawa K, Toyama T, Noh W, Jeong J, Cardoso F, Sriuranpong V, Srimuninnimit V, Ozguroglu M, Kendall S, Falkson C, Cianfrocca M, Manlius C, Lin JCJ, Ringeisen F, Ridolfi A, Royce M. Stomatitis in Patients Treated with First-line Everolimus (EVE) Plus Letrozole (LET): Results From BOLERO-4 Trial. 2016 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 6-10, 2016.
Endo Y, Dong Y, Kondo N, Hato Y, Hisada T, Nishimoto M, Nishikawa S, Takahashi S, Toyama T. Exome sequencing analysis in human breast cancer tissues showing resistance for taxanes. 2016 Annual San Antonio Breast Cancer Symposium (San Antonio, U.S.A), December 6-10, 2016.
Yamamoto Y, Iwata H, Ueno T, Kashiwaba M, Taira N, Takahashi M, Tada H, TsugawaK, Toyama T, Niikura N, Hara F, Fujisawa T, Yoshinami T, Saji S, Takano T, Masuda N, Morita S, Toi M, Ohno S. A randomized, open-label phase III Trial of pertuzumab retreatment in HER2-positive locally advanced/metastatic breast cancer patients who were previously treated with pertuzumab, trastuzumab, and chemotherapy:JBCRG-M05(PRECIOUS) trial. The 51th Annual meeting of American Society of Clinical Oncology (ASCO), June 3-7, 2016 (Chicago, IL, USA).
Naoto Kondo, Yutaka Yamamoto*, Hiroyasu Yamashiro*, Masahiro Kashiwaba*, Rikiya Nakamura*, Masato Takahashi*, Uhi Toh*, Koichiro Tsugawa*, Kazutaka Narui* , Kentaro Tamaki*, Tetsuhiro Yoshinami*, Shoichiro Ohtani*, Yuichiro Kai*, Toshimi Takano*, Yasuhiro Yanagita*, Satoshi Morita*, Masakazu Toi* , Shinji Ohno*. Prospective observational cohort study of bevacizumab combined with paclitaxel as the first- or second-line chemotherapy for locally advanced or metastatic breast cancer (Study JBCRG-C05: B-SHARE), 10th European Breast Cancer Conference, March 9-11, 2016 (Amsterdam, Netherlands).
Naoto Kondo, Yoshinori Ito*, Ippei Fukada*, Shoichiro Ohtani*, Masaya Hattori*, Eriko Tokunaga*, Nobuki Matsunami *, Kohjiro Mashino*, Taijiro Kosaka*, Masahiko Tanabe* , Daisuke Yotsumoto*, Kosho Yamanouchi*, Masataka Sawaki*. Efficacy study of sequential therapy with anthracycline, taxane, and eribulin in patients with HER2-negative locally advanced breast cancer (JBCRG-17)., The 51th Annual meeting of American Society of Clinical Oncology (ASCO), June 3-7, 2016 (Chicago, IL, USA).
Fujisawa T, Iwata H, Sakai T, Nakamura R, Hasegawa Y, Ohtani S, Kashiwaba M, Taira N, Toyama T, Masuda N, Yamamoto Y, Kihara1 K, Shimozuma K, Ohashi Y, Mukai H. Endocrine-related symptoms during neoadjuvant endocrine therapy for breast cancer: Agreement between patient and physician reporting in a prospective clinical trial. 2015 Annual San Antonio Breast Cancer Symposium, December 8-12, 2015 (San Antonio, U.S.A).
Kurebayashi J, Toyama T, Sumino S, FujimotoT. Hormone dynamics, pharmacokinetics, safety and efficacy of leuprorelin acetate 6-month depot formulation and tamoxifen adjuvant endocrine therapy combination in premenopausal patients with hormone receptor-positive breast cancer. 2015 Annual San Antonio Breast Cancer Symposium, December 8-12, 2015 (San Antonio, U.S.A).
Ohashi Y, Shiba E, Toyama T, Kurebayashi J, Noguchi S, Iwase H. QOL score changes in breast cancer patients: 2-year vs. 3-or-more-year administration of leuprolin. 14th St. Gallen Breast Cancer Conference, March 18-21, 2015 (Vienna, Austria)
Hato Y, Endo Y, Yoshimoto N, Asano T, Dong Y, Takahashi S, Fujii Y, Toyama T. Prognostic impact of SNPs in or near the ZNF423 and CTSO genes in early breast cancer patients. 14th St. Gallen Breast Cancer Conference, March 18-21, 2015 (Vienna, Austria)
Hato Y, Endo Y, Kondo N, Yoshimoto N, Nishimoto M, Toyama T. Mutations of estrogen receptor α gene in Japanese breast cancer patients. 第74回日本癌学会学術総会、2015年10月8日~10日(名古屋)
2014
Toyama T, Asano T, Sato S, Yoshimoto N, Endo Y, Hato Y, Yu D, Takahashi S, Fujii Y. High expression of LMTK3 is an independent factor indicating a poor prognosis in Japanese estrogen receptor α-positive breast cancer patients. 2014 Annual San Antonio Breast Cancer Symposium, Dec 9-13, 2014 (San Antonio, U.S.A).
Hato Y, Endo Y, Yoshimoto N, Asano T, Yamaguchi M, Takahashi S, Toyama T. Prognostic impact of single-nucleotide polymorphisms (SNPs) in or near the ZNF423 and CTSO genes in estrogen receptor (ER)-positive breast cancer patients receiving adjuvant endocrine therapy. 2014 Annual San Antonio Breast Cancer Symposium, Dec 9-13, 2014 (San Antonio, U.S.A).
Sakai T, Iwata H, Hasegawa Y, Nakamura R, Akabane H, Ohtani S, Kashiwaba M, Taira N, Toyama T, Yamamoto Y, Fujisawa T, Masuda N, Yamaguchi T, Mukai H, Ohashi Y. First report of clinicopathological analysis in neoadjuvant treatment phase in NEOS: A randomized study of adjuvant endocrine therapy with or without chemotherapy for postmenopausal breast cancer patients who responded to neoadjuvant letrozole. 2014 Annual San Antonio Breast Cancer Symposium, Dec 9-13, 2014 (San Antonio, U.S.A).
Endo Y, Yamashita H, Takahashi S, Sato S, Yoshimoto N, Asano T, Hato Y, Yamaguchi M, Dong Y, Toyama T. Immunohistochemical determination of arylamine N-acetyltransferase 1 (NAT1) as the target of miR-1290 and prognostic biomarker of breast cancer. 2014 Annual San Antonio Breast Cancer Symposium, Dec 9-13, 2014 (San Antonio, U.S.A).
Hara F, Matsubara N, Saito T, Takano T, Park Y, Toyama T, Hozumi Y, Tsurutani J, Imoto S, Takashima T, Watanabe T, Sagara Y, Nishimura R, Ohashi Y, Mukai H. Randomized phase III study of Taxane versus TS-1 as first-line treatment for metastatic breast cancer (SELECT BC). The 50th Annual meeting of American Society of Clinical Oncology (ASCO), May 30-June 3, 2014 (Chicago, IL, USA).
Yoshimoto N, Nishiyama T, Yamashita H, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Hato Y, Fujii Y, Toyama T. Association of the single nucleotide polymorphism TNRC9 rs3803662 on mammographic density and estrogen receptor-positive breast cancer risk in Japanese women. The 50th Annual meeting of American Society of Clinical Oncology (ASCO), May 30-June 3, 2014 (Chicago, IL, USA).
Yoshimura A, Iwata H, Hayashi T, Kobayshi N, Saito S, Tsuneizumi M, Sawaki M, Hattori M, Nakata T, Yokota I, Toyama T. A randomized phase II study evaluating the use of pyridoxine to prevent hand-foot syndrome associated with capecitabine therapy for advanced or metastatic breast cancer. The 50th Annual meeting of American Society of Clinical Oncology (ASCO), May 30-June 3, 2014 (Chicago, IL, USA).
Tsurutani J, Hara F, Matsubara N, Saito T, Takano T, Park Y, Toyama T, Hozumi Y, Imoto S, Takashima T, Watanabe T, Sagara Y, Nishimura R, Ohashi Y, Mukai H. <プレナリーセッション>Current Perspective of Chemotherapy in metastatic breast cancer: New Evidence from SELECT BC trial. 第12回日本臨床腫瘍学会学術総会、2014年7月17-19日(福岡)
遠藤友美、董宇、吉本信保、浅野倫子、波戸ゆかり、山下啓子、佐藤慎哉、高橋智、藤井義敬、遠山竜也. <English Oral Session> HER2 mutation status in Japanese HER2-negative breast cancer patients. 第73回日本癌学会学術総会 2014年9月25日-27日
2013
Toyama T, Asano T, Sato S, Yoshimoto N, Endo Y, Hato Y, Takahashi S, Yamashita H. Relationship between plasma estradiol levels and estrogen-regulated gene expressions in premenopausal estrogen receptor-positive breast cancers. 36th Annual San Antonio Breast Cancer Symposium, Dec10-14, 2013 (San Antonio, U.S.A).
Yamamoto Y,Ishikawa T, Hozumi Y, Ikeda M, Kondo N, Yamashita H, Toyama T, Chishima C, Saji S, Yamamoto-Ibusuki M, Iwase H. Randomized controlled trial of toremifene120 mg compared with exemestane 25 mg after prior treatment with a non-steroidal aromatase inhibitor in postmenopausal women with hormone receptor-positive metastatic breast cancer (Hi-FAIR ex Trial). 36th Annual San Antonio Breast Cancer Symposium, Dec10-14, 2013 (San Antonio, U.S.A).
Iwata H, Ohtani S, Fujisawa T, Taira N, Masuda N, Kashiwaba M, Yamamoto Y, Toyama T, Yamaguchi T, N-SAS BC06: A phase III study of adjuvant endocrine therapy with or without chemotherapy for postmenopausal breast cancer patients who responded to neoadjuvant letrozole (LET): the new primary endocrine-therapy origination study (NEOS). 2013 Annual meeting of American Society of Clinical Oncology (ASCO), May 31-June 4, 2013 (Chicago, IL, USA)
Endo Y, Toyama T, Takahashi S, Yoshimoto N, Iwasa M, Asano T, Fujii Y, Yamashita H. MiR-1290 and its potential targets are associated with characteristics of estrogen receptor α-positive breast cancer. 2013 Annual meeting of American Society of Clinical Oncology (ASCO), May 31-June 4, 2013 (Chicago, IL, USA)
Endo Y, Toyama T, Takahashi S, Yoshimoto N, Iwasa M, Asano T, Fujii Y, Yamashita H. MicroRNAs and their potential targets associated with characteristics of estrogen receptor-positive breast cancer. St. Gallen Breast Cancer Conference, March 13-17, 2013 (St. Gallen, Switzerland)
2012
Hirotaka Iwase, Yutaka Yamamoto, Takashi Ishikawa, Yasuo Hozumi, Masahiko Ikeda, Hiroji Iwata, Hiroko Yamashita, Tatsuya Toyama, Takashi Chishima, Izo Kimijima, Mutsuko Yamamoto-Ibusuki, Shigehira Saji: Phase II randomized trial of toremifene 120 mg compared with exemestane 25 mg after prior nonsteroidal aromatase inhibitor in postmenopausal women with hormone receptor-positive breast cancer. ASCO BCS(American Society Cancer Oncology Breast Cancer Symposium), September 13-15, 2012. (San Francisco, USA)
Yamashita H, Toyama T, Takahashi S, Yoshimoto N, Endo Y: <Workshop: Molecular targeted cancer therapy and histochemistry> Role of microRNAs in estrogen receptor α-positive breast cancer. 14th International Congress of Histochemistry and Cytochemistry (ICHC 2012), Aug26-29, 2012. (Kyoto, Japan).
Yamashita H, Toyama T, Yoshimoto N, Endo Y, Takahashi S: <Symposium: Breast cancer (Clinical research)> Role of microRNAs in estrogen receptor-positive breast cancer. 15th International Congress on Hormonal Steroids and Hormones & Cancer (15th ICHSHC), Nov15-17, 2012. (Kanazawa, Japan).
Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Fujii Y, Yamashita H. A mammographic density prediction model using environmental factors, endogenous hormones and growth factors in Japanese women. 35th Annual San Antonio Breast Cancer Symposium, Dec4-8, 2012 (San Antonio, U.S.A).
2011
Toyama T, Kondo N, Endo Y, Sugiura H, Yoshimoto N, Iwasa M, Takahashi S, Iwase H, Fujii Y, Yamashita H: Low Expression of microRNA-210 Is an Independent Good Prognostic Factor in Japanese Triple-Negative Breast Cancer Patients, 34rd Annual San Antonio Breast Cancer Symposium, Dec6-10, 2011. (San Antonio, USA)
Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H: Genetic and Environmental Predictors, Endogenous Hormones and Growth Factors and Risk of Estrogen Receptor-Positive Breast Cancer in Japanese Women, 34rd Annual San Antonio Breast Cancer Symposium, Dec6-10, 2011. (San Antonio, USA)
Iwata H, Yamaguchi T, Masuda N, Toyama T, Kashiwaba M, Yamamoto Y, Taira N, Saji S, Ohashi Y: A randomized study of adjuvant endocrine therapy with or without chemotherapy for postmenopausal breast cancer patients who responded to neoadjuvant letrozole: An interim efficacy analysis of the new primary endocrine-therapy origination study (NEOS / N-SAS BC06), 34rd Annual San Antonio Breast Cancer Symposium, Dec6-10, 2011. (San Antonio, USA)
2010
Yamashita H, Yoshimoto N, Toyama T, Takahashi S, Sugiura H, Endo Y, Iwasa M, Fujii Y: Distinct expressions of microRNAs that directly target estrogen receptor a in human breast cancer. Advances in Breast Cancer Research, American Association for Cancer Research (AACR) Special Conference in Cancer Research, October 12-15, 2011 (San Francisco, U.S.A.)
Yamashita H, Iwase H, Toyama T, Takahashi S, Sugiura H, Yoshimoto N, Endo Y, Fujii Y, Kobayashi S: Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics, and prognosis, 33rd Annual San Antonio Breast Cancer Symposium, Dec8-12, 2010. (San Antonio, USA)
Yamashita H, Iwase H, Toyama T, Takahashi S, Sugiura H, Yoshimoto N, Endo Y, Kobayashi S: Estrogen receptor-positive breast cancer in Japanese women: trends in incidence, characteristics, and prognosis, The 6th International symposium on Hormonal Oncogenesis, Sep12-16, 2010. (Tokyo, Japan)
2009
Iwata H, Yamaguchi T, Masuda N, Toyama T, Taira N, Yamamoto Y, Saji S, Kashiwaba M, on behalf of the NEOS: Randomized phase III study of adjuvant endocrine-therapy with or without chemotherapy for postmenopausal breast cancer patients who responded to neoadjuvant letrozole, St. Gallen Oncology conference 2009, Mar11-14, 2009. (St. Gallen, Switzerland)
Yoshimoto N, Takahashi S, Ito Y, Yamashita T, Ando Y, Toyama T, Sugiura H, Kobayashi S, Fujii Y, Iwase H, Yamashita H: Predictors of response to exemestane as primary endocrine therapy in estrogen receptor-positive breast cancer. 32th Annual San Antonio Breast Cancer Symposium, Dec. 9-13, 2009. (San Antonio, USA)
2008
Kondo N, Toyama T, Sugiura H, Fujii Y, Yamashita H:
MicroRNA-206 expression is down-regulated in estrogen receptor α-positive human breast cancer.
31th Annual San Antonio Breast Cancer Symposium. Dec. 10-14, 2008 (San Antonio, USA)
Yamashita H, Kondo N, Toyama T, Sugiura H, Fujii Y:
MicroRNA-206 expression is down-regulated in estrogen receptor-positive human breast cancer.
26th congress of the international association for breast cancer research (IABCR). Sept. 22-24, 2008 (Kurashiki, Japan)
Iwase H, Yamamoto Y, Otake T, Masuda N, Yamashita H, Saji S, Kimishima I, Kasahara Y, Ishikawa T, Sawaki M:
Clinical usefulness of high-dose toremifene for patients failed by treatment with aromatase inhibitor.
6th European Breast Cancer Conference. Apr. 15-19, 2008 (Berlin, Germany)
2007
Sugiura H, Toyama T, Kondo N, Kobayashi S, Fujii Y, Yamashita H:
High phosphorylation of estrogen receptor α serine 167 and low p53 protein accumulation improve survival in estrogen receptor-positive breast cancer patients treated with tamoxifen.
30th Annual San Antonio Breast Cancer Symposium. Dec. 13-16, 2007 (San Antonio, USA)
Yamashita H, Toyama T, Sugiura H, Kondo N, Takahashi S, Fujii Y:
Low phosphorylation of estrogen receptor (ER) α serine 118 and high phosphorylation of ERα serine 167 improve survival in ER-positive breast cancer.
4th Annual Conference of Organisation for Oncology and Translational Research (OOTR). Nov. 9-10, 2007 (Kyoto, Japan)
Yamashita H, Toyama T, Nishio M, Sugiura H, Kondo N, Takahashi S, Fujii Y, Iwase H:
Predictive factors for aromatase inhibitors in ER-positive, HER2-negative breast cancer.
Advances in Breast Cancer Research, American Association for Cancer Research (AACR) Special Conference in Cancer Research. Oct. 17-20, 2007 (San Diego, USA)
Toyama T, Zhang Z, Hamaguchi M, Kondo N, Iwase H, Iwata H, Takahashi S, Yamashita H, Fujii Y:
Association of p53 codon 72 polymorphism with resistance to adjuvant therapy in breast cancer.
43th Annual Meeting of American Society of Clinical Oncology (ASCO). Jun. 1-5, 2007 (Chicago, USA)
2006
Yamashita H, Nishio M, Toyama T, Zhang Z, Hamaguchi M, Kobayashi S, Fujii Y, Iwase H:
Stat5 expression predicts response to endocrine therapy and improves survival in estrogen receptor-positive breast cancer.
97th Annual Meeting of American Association for Cancer Research (AACR). Apr. 1-5, 2006 (Washington DC, USA)
2005
Yamashita H, Ando Y, Hamaguchi M, Mita K, Fujii Y, Kobayashi S, Iwase H:
Phosphorylation of estrogen receptor α serine 167, but not serine 118, and expression of progesterone receptor A and B are predictive of response to endocrine therapy and increase post-relapse survival in metastatic breast cancer.
96th Annual Meeting of American Association for Cancer Research (AACR). Apr. 16-20, 2005 (Anaheim, USA)
2004
Toyama T, Iwase H, Yamashita H, Hara Y, Sugiura H, Zhang Z, Fukai I, Miura Y, Riabowol K, Fujii Y:
p33ING1b stimulates the transcriptional activity of the estrogen receptor α via its activation function (AF) 2 domain.
18th Annual Meeting of European Association for Cancer Research. Jun. 4-6, 2004 (Insbruck, Austria)
Iwase H, Yamashita H, Omoto Y, Toyama T, Sugiura H, Zhang Z, Hayashi S:
Clinical significance of histone deactylase 6 expression in breast cancer.
FGOG Congress. Jan. 15-17, 2004 (Brussels, Belgium)
Iwase H:
The Role of Nuclear Receptors in Carcinogenesis: Expression of ERα/β, PgR and cofactors in breast cancer tissues with reference to the response to endocrine therapy.
30th Anniversary of US-Japan Cooperative Cancer Research: Workshop. Mar. 22-23, 2004 (Maui, USA)
Yoshimoto N, Iwata H, Hattori K, Naito A, Yokoyama T, Kawahara K:
PET/CT can strictly locate the putative metastasis of breast cancer.
Leura V International Breast Cancer Conference. Nov. 10-14, 2004 (Sydney, Australia)
2003
Yamashita H, Iwase H, Toyama T, Sugiura H, Zhenhuan Zhang, Fujii Y:
Dominant-negative Stat5 induces apoptosis in estrogen receptor-positive breast cancer cells T47D.
94th Annual Meeting of American Association for Cancer Research (AACR). Jul. 11-14, 2003 (Washington DC, USA)
Iwase H:
Special Lecture, Hormone receptors and endocrine therapy for breast cancer.
7th biannual Chinese Breast Cancer Meeting. Sep. 10-13, 2003 (Chonqing, China)
Iwase H:
-Current Perspectives and the Future- Clinical usefullness of biweekly paclitaxel in patients with metastatic breast cancer.
Investigators Meeting for Breast Cancer. Jan. 12, 2003 (Bangkok, Thailand)
2002
Yamashita H, Iwase H, Toyama T, Omoto Y, Fujii Y, Rui H:
Adenoviral-mediated gene delivery of dominant-negative Stat5 induces apoptosis in human breast cancer cells T47D.
93rd Annual Meeting of American Association for Cancer Research (AACR). Apr. 6-10, 2002 (San Francisco, USA)
Iwase H:
<International Symposium>Clinical Significance of biological markers for breast cancer treatment.
18th International Symposium for Cancer Treatment. Nov. 8-9, 2002 (Nagoya, Japan)
Iwase H, Yamashita H, Toyama T, Hara Y, Sugiura H, Zhang Z, Omoto Y, Kobayashi S:
Evaluation of aromatase mRNA expression and relationship with clinicopathologic factors in breast cancer.
VI International Aromatase Conference “Aromatase 2002”. Oct. 26-30, 2002 (Kyoto, Japan)
Omoto Y, Iwase H, Hayashi S:
Estrogen receptor (ER) β and ERβcx expression in human breast cancer and functions in ERα positive human breast cancer cell line.
International Congress on Hormonal Steroids and Hormones and Cancer (IHCS & HC). Oct. 21-25, 2002 (Fukuoka, Japan)
Zhang Z, Yamashita H, Toyama T, Omoto Y, Sigiura H, Kobayashi S, Harada N, Iwase H:
Semi-quantitive immunohistochemical analysis of aromatase expression in DCIS.
ABCS sessions, 10th annual meeting of Japanese Breast Cancer Society. Jul. 5-6, 2002 (Nagoya, Japan)
2001
Kobayashi S:
Epidemiology Session, Epidemiology of breast cancer in Aia; Trend of Breast Cancer Clinic in Japan.
3rd Biennial Meeting of the Asian Breast Cancer Society. Jun. 14-15, 2001 (Seoul, Korea)
Iwase H, Ando Y, Yamashita H, Toyama T, Kobayashi S:
Loss of heterozygosity and Microsatellite instability in ductal carcinoma in situ of the breast.
3rd Biennial Meeting of the Asian Breast Cancer Society. Jun. 14-15, 2001 (Seoul, Korea)
Park SH, Yamashita H, Rui H, Waxman DJ:
Growth hormone-induced serine phosphorylation of Stat5a and Stat5b: Impact on Stat5 transcriptional activity.
Endocrine Society's 83rd Annual Meeting. Jun. 20-23, 2001 (Denver, USA)
2000
Kobayashi S, Ito Y, Yamashita H, Ando Y, Omoto Y, Toyama T, Hara Y, Iwase H:
Comparison of five different antibodies in the immunohistochemical assay of estrogen receptor alpha in human breast cancer.
2nd Europian Breast Cancer Conference. Sep. 26-30, 2000 (Brussels, Belgium)
Omoto Y, Inoue S, Iwase H, Yamashita H, Toyama T, Hara Y, Ogawa S, Muramatsu M, Kobayashi S:
Expression of estrogen receptor β protein analyzed by Immunohistochemistry in human breast cancers.
2nd Europian Breast Cancer Conference. Sep. 26-30, 2000 (Brussels, Belgium)
Toyama T, I Garkavtsev I, Iwase H, Watson P, Muzik H, Saettler E, Magliocco A, DiFrancesco L, Forsyth P, Kobayashi S, and Riabowol K:
Suppression of ING1 Expression in Sporadic Breast Cancer.
91st Annual Meeting of American Association for Cancer Research (AACR). Apr. 1-5, 2000 (San Francisco, USA)
Yamashita H, Rui H:
Adenovirus-mediated gene delivery of dominant-negative Stat5 supports growth of MCF-7 human breast cancer cells.
91st Annual Meeting of American Association for Cancer Research (AACR). Apr. 1-5, 2000 (San Francisco, USA)
1999
Omoto Y, Iwase H, Iwata H, Hara Y, ANdo Y, Kobayashi S:
Estrogen receptor alpha and beta expression in Japanese breast cancer analyzed by RT-PCR.
AACR special conference in cancer research “The steroid receptor superfamily”. Jan. 8-12, 1999 (Indian Wells, USA)
Kobayashi S, Iwase H, Ito Y, Iwata H, Toyama T, Hara Y, Omoto Y:
DNA methylation analysis at two promoter regions of the estrogen receptor alpha gene in breast cancers.
2nd Biannual Meeting of Asia Breast Cancer Society Sep. 1-3, 1999 (TianJin, China)
Omoto Y, Iwase H, Muramatsu M, Inoue S, Ogawa S, Iwata H, Hara Y, Toyama T, Kobayahsi S:
Immunohistochemical study of estrogen receptor alpha and beta in human breast cancers.
2nd Biannual Meeting of Asia Breast Cancer Society. Sep. 1-3, 1999 (TianJin, China)
Vieyra D, Toyama T, Bonnefin P, Scott M, Riabowol K:
Function of the novel candidate tumor suppressor gene ING1 in apoptosis.
1999 Alberta Cancer Board Annual Research Meeting. Nov. 8-10, 1999 (Edmonton, Canada)
1998
Iwase H, Iwata H, Ito Y, Toyama T, Hara Y, Omoto Y, Ando Y, Kobayashi S:
DNA methylation analysis at P0 and P1 promotor region of the estrogen receptor gene in breast cancer.
21st San Antonio Breast Cancer Symposium. Dec. 12-15, 1998 (San Antonio, USA)
Toyama T, Garkavtsev I, Iwase H, Watson P, Muzik H, Saettler E, Maglicco A, DiFrancesco L, Forsyth P, Kobayashi S, Riabowel K:
Down regulation of the ING1 candidate tumr suppressor gene is highly correlated with the development of sporadic breast cancer.
21st San Antonio Breast Cancer Symposium. Dec. 12-15, 1998 (San Antonio, USA)
Iwase H, Iwata H, Ito Y, Toyama T, Hara Y, Omoto Y, Ando Y, Fujii Y, Kobayashi S:
The clinical value of microsatellite instability and loss of heterozygosity in breast cancers.
1st Roche International Synposium on Cancer Research. Nov. 21-22, 1998
Kobayashi S, Iwase H, Omoto Y, Hara Y, Ando Y:
Estrogen receptor alpha and beta expression in human breast cancer tissues analyzed by RT-PCR.
European Breast Cancer Conference. Sep. 30, 1998 (Florence, Italy)
Toyama T, Parr E, Chebib I, Garkavtsev I, Musik H, Magliocco A, Watson P, Kazarov A, Gudkov A, Forsyth P, Riabowol K:
Expression of the ING1 growth inhibitor and candidate tumor suppressor is lost in majority of brain tumor.
41th General Meeting of the Canadian Society of Biochemistry, Molecular and Cellular Biology. Jun. 17-21, 1998 (Edmonton, Canada)
Toyama T, Garkavtsev I, Iwase H, Watson P, Muzik H, Saettler E, Magliocco A, Defrancesco L, Forsyth P, Kobayashi S, Riabowol K:
Down regulation of the candidate tumor suppressor gene ING1 is linked to in vivo aggressiveness of sporadic breast cancer.
Research Accoplishment of Medical Research Council of Canada at Calgary. Jun. 17, 1998 (Calgary, Canada)
Toyama T, Garkavtsev I, Chebib I, Parr E, Meyyappan M, Riabowol K:
The tumor suppressor binds p53 and may be involved in blocking cell growth in response to DNA damage DNA repair and mutagenesis
’98. Feb. 6, 1998 (Sendai, Japan)
-1997
Iwase H, Kobayashi S:
Estrogen receptor gene and breast cancer susceptibility.
UICC Symposium Familial Cancer and Prevention. May 14-16, 1997 (Kobe Japan)
Toyama T, Garkavtsev I, Muzik H, Magliocco A, DeFrancesco L. Iwase H, Kobayashi S, Forsyth P, Riabowl K:
Mutation and expression analysis of a novel candidate tumor suppressor gene, ING1.
15th Meeting of Western Canada Cancer Research. Oct. 18, 1997 (Banff, Canada)
Iwase H, Toyama T, Iwata H, , Yamashita H, Hara H, Omoto Y, KatoT, Kobayashi S: ”Impact of Cancer Biotechnology, on Diagnostic and Prognostic Indicators in Predictive Oncology & Therapy” Microsatellite instability in in situ, and invasive breast cancers. 3rd International Symposium. Oct. 26-28, 1996 (Nice, France)
Iwata H, Iwase H, Toyama T, Hara Y, Omoto Y, Okada Y, Kobayashi S:
”Impact of Cancer Biotechnology, on Diagnostic and Prognostic Indicators in Predictive Oncology & Therapy” Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinoma.
3rd International Symposium. Oct. 26-28, 1996 (Nice, France)
Kobayashi S, Iwase H, Itoh Y, Yamashita H, Kuzushima T, Iwata H., Itoh K,Yamashita T, Naitoh A, Masaoka A:
Prognostic significance of bcl-2 expression in human breast cancer.
20th Meeting of the International Associatin for Breast Cancer Research. Sep. 25-28, 1994 (Senndai, Japan)
Iwase H, Kobayashi S, Itoh Y, Kuzushima T, Iwata H, Masaoka A:
Simultaneous quantitative analyses of ErbB2 protein, EGFR, Cathepsin D and hormone receptors in breast cancer tissues.
International Simposium on biochemical diagnostic and prognostic indicators. Dec. 11-13, 1994 (Boston, USA)
山下啓子、遠山竜也、安藤由明、山下年成、杉浦博士、近藤直人、高橋智、藤井義敬、岩瀬弘敬:Predictive factors for aromatase inhibitors in ER-positive, HER2-negative breast cancer. 第66回日本癌学会2007年10月3-5日(横浜)
張 震寰、山下啓子、遠山竜也、杉浦博士、安藤由明、三田圭子、濱口真帆、川口 誠、三浦裕、岩瀬弘敬:ATBF1-A mRNA expression is correlated with better prognosis in breast cancer 第13回日本乳癌学会2005年6月10-11日(倉敷)
Iwase H: Current status of endocrine therapy for breast cancer. -Endocrine therapy for breast cancer- 1st Breast Cancer Frontier Meeting. Oct. 11, 2003 (Tokyo)