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研究業績：Achievements

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准教授   田尻　直輝／Naoki Tajiri., Associate Professor

2019年

  1. Shinozuka K, Tajiri N, Ishikawa H, Tuazon JP, Lee JY, Sanberg PR, Zarriello S, Corey S, Kaneko Y, Borlongan CV. (2019) Empathy in stroke rats is modulated by social settings. J Cereb Blood Flow Metab. In press.
  2. Pianta S, Lee JY, Tuazon JP, Castelli V, Mantohac LM, Tajiri N, Borlongan CV. (2019) A Short Bout of Exercise Prior to Stroke Improves Functional Outcomes by Enhancing Angiogenesis. Neuromolecular Med. In press.

2018年

  1. Kin K, Yasuhara T, Kameda M, Tomita Y, Umakoshi M, Kuwahara K, Kin I, Kidani N, Morimoto J, Okazaki M, Sasaki T, Tajiri N, Borlongan CV, Date I. (2018) Cell encapsulation enhances antidepressant effect of the mesenchymal stem cells and counteracts depressive-like behavior of treatment-resistant depressed rats. Mol Psychiatry. In press.
  2. Patel NA, Moss LD, Lee JY, Tajiri N, Acosta S, Hudson C, Parag S, Cooper DR, Borlongan CV, Bickford PC. (2018) Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury. J Neuroinflammation. 15(1):204.
  3. Morimoto J, Yasuhara T, Kameda M, Umakoshi M, Kin I, Kuwahara K, Kin K, Okazaki M, Takeuchi H, Sasaki T, Toyoshima A, Tajiri N, Agari T, Borlongan CV, Date I. (2018) Electrical stimulation enhances migratory ability of transplanted bone marrow stromal cells in a rodent ischemic stroke model. Cellular Physiology & Biochemistry. 46(1):57-68.

2017年

  1. Kin K, Yasuhara T, Kameda M, Agari T, Sasaki T, Morimoto J, Okazaki M, Umakoshi M, Kuwahara K, Kin I, Tajiri N, Date I. (2017) Hippocampal neurogenesis of Wistar Kyoto rats is congenitally impaired and correlated with stress resistance. Behavioural Brain Research. 329:148-156.
  2. Tajiri N, Quach DM, Kaneko Y, Wu S, Lee D, Lam T, Hayama KL, Hazel TG, Johe K, Wu MC, Borlongan CV. (2017) NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructual benefits in stroke rats. Journal of Cellular Physiology. 232(10):2731-2740.
  3. Kaneko Y, Pappas C, Malapira T, Vale FL, Tajiri N, Borlongan CV. (2017) Extracellular HMGB1 modulates glutamate metabolism associated with kainic acid-induced epilepsy-like hyperactivity in primary rat neural cells. Cellular Physiology & Biochemistry. 41(3):947-959.
  4. Acosta SA, Tajiri N, Sanberg PR, Kaneko Y, Borlongan CV. (2017) Increased amyloid precursor protein and tau expression manifests as key secondary cell death in chronic traumatic brain injury. Journal of Cellular Physiology. 232(3):665-677.

2016年

  1. Kaneko Y, Pappas C, Tajiri N, Borlongan CV. (2016) Oxytocin modulates GABAAR subunits to confer neuroprotection in stroke in vitro. Scientific Reports. 6:35659.
  2. Garbuzova-Davis S, Haller E, Tajiri N, Thomson A, Barretta J, Williams SN, Haim ED, Qin H, Frisina-Deyo A, Abraham JV, Sanberg PR, van Loveren H, Borlongan CV. (2016) Blood-spinal cord barrier alterations in subacute and chronic stages of a rat model of focal cerebral ischemia. Journal of Neuropathology & Experimental Neurology. 75(7):673-688.
  3. Tajiri N, Borlongan CV, Kaneko Y. (2016) Cyclosporine A treatment abrogates ischemia-induced neuronal cell death by preserving mitochondrial integrity through upregulation of the Parkinson’s disease-associated protein DJ-1. CNS Neuroscience & Therapeutics. 22(7):602-610.
  4. Tajiri N, Lee JY, Acosta SA, Sanberg PR, Borlongan CV. (2016) Breaking the blood-brain barrier with mannitol to aid stem cell therapeutics in the chronic stroke brain. Cell Transplantation. 25(8):1453-1460.
  5. Tajiri N, Dela Peña IC, Acosta SA, Kaneko Y, Tamir S, Landesman Y, Carlson R, Shacham S, Borlongan CV. (2016) A nuclear attack on traumatic brain injury: Sequestration of cell death in the nucleus.
    CNS Neuroscience & Therapeutics. 22(4):306-315.
  6. Kaneko Y, Sullivan R, Dailey T, Vale FL, Tajiri N, Borlongan CV. (2016) Kainic acid-induced golgi complex fragmentation/dispersal shifts the proteolysis of reelin in primary rat neuronal cells: An in vitro model of early stage epilepsy. Molecular Neurobiology. 53(3):1874-1883.
  7. Pabón MM, Acosta SA, Guedes VA, Tajiri N, Kaneko Y, Borlongan CV. (2016) Brain region-specific histopathological effects of varying trajectories of controlled cortical impact injury model of traumatic brain injury. CNS Neuroscience & Therapeutics. 22(3):200-211.

2015年

  1. Acosta SA, Tajiri N, Hoover J, Kaneko Y, Borlongan CV. (2015) Intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke. Stroke. 46(9):2616-2627.
  2. Dela Peña IC, Yoo A, Tajiri N, Acosta SA, Ji X, Kaneko Y, Borlongan CV. (2015) Granulocyte colony-stimulating factor attenuates delayed tPA-induced hemorrhagic transformation in ischemic stroke rats by enhancing angiogenesis and vasculogenesis. Journal of Cerebral Blood Flow & Metabolism. 35(2):338-346.
  3. Acosta SA, Tajiri N, Dela Peña IC, Bastawrous M, Sanberg PR, Kaneko Y, Borlongan CV. (2015) Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson’s disease. Journal of Cellular Physiology. 230(5):1024-1032.

2014年

  1. Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Sanberg PR, Sanchez-Ramos J, Song S, Kaneko Y, Borlongan CV. (2014) Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury. PLoS One. 9(3):e90953.
  2. Tajiri N, Quach DM, Kaneko Y, Wu S, Lee D, Lam T, Hayama KL, Hazel TG, Johe K, Wu MC, Borlongan CV. (2014) Behavioral and histopathological assessment of adult ischemic rat brains after intracerebral transplantation of NSI-566RSC cell lines. PLoS One. 9(3):e91408.
  3. Garbuzova-Davis S, Haller E, Williams SN, Haim ED, Tajiri N, Hernandez-Ontiveros DG, Frisina-Deyo A, Boffeli SM, Sanberg PR, Borlongan CV. (2014) Compromised blood‐brain barrier competence in remote brain areas in ischemic stroke rats at the chronic stage. The Journal of Comparative Neurology.522(13):3120-3137.
  4. Tajiri N, Hernandez-Ontiveros DG, Acosta SA, Shinozuka K, Ishikawa H, Ehrhart J, Diamandis T, Gonzales-Portillo C, Borlongan MC, Tan J, Kaneko Y, Borlongan CV. (2014) Suppressed cytokine expression immediately following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response. Brain Research. 1559:65-71.
  5. Kaneko Y, Tajiri N, Shojo H, Borlongan CV. (2014) Oxygen-glucose-deprived rat primary neural cells exhibit DJ-1 translocation into healthy mitochondria: A potent stroke therapeutic target. CNS Neuroscience & Therapeutics.20(3):275-281.
  6. Tajiri N, Acosta SA, Shahaduzzaman M, Ishikawa H, Shinozuka K, Pabon MM, Hernandez-Ontiveros DG, Kim DW, Metcalf C, Staples M, Dailey T, Vasconcellos J, Franyuti G, Gould L, Patel N, Cooper D, Kaneko Y, Borlongan CV, Bickford PC. (2014) Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: Cell graft biodistribution and soluble factors in young and aged rats. Journal of Neuroscience. 34(1):313-326.
  7. Kaneko Y, Shojo H, Burns J, Staples M, Tajiri N, Borlongan CV. (2014) DJ-1 ameliorates ischemic cell death in vitro possibly via mitochondrial pathway.
    Neurobiology of Disease. 62:56-61.

2013年

  1. Acosta SA, Diamond DM, Wolfe S, Tajiri N, Shinozuka K, Ishikawa H, Hernandez-Ontiveros DG, Sanberg PR, Kaneko Y, Borlongan CV. (2013) Influence of post-traumatic stress disorder on neuroinflammation and cell proliferation in a rat model of traumatic brain injury. PLoS One. 8(12):e81585.
  2. Tajiri N, Kellogg SL, Shimizu T, Arendash GW, Borlongan CV. (2013) Traumatic brain injury precipitates cognitive impairment and extracellular Aβ aggregation in Alzheimer's disease transgenic mice.
    PLoS One. 8(11): e78851.
  3. Borlongan CV, Burns J, Tajiri N, Stahl CE, Weinbren NL, Shojo H, Sanberg PR, Emerich DF, Kaneko Y, van Loveren H. (2013) Epidemiological survey-based formulae to approximate incidence and prevalence of neurological disorders in the United States: A meta-analysis. PLoS One.8(10):e78490.
  4. Ishikawa H, Tajiri N, Shinozuka K, Vasconcellos J, Kaneko Y, Lee H, Mimura O, Dezawa M, Kim SU, Borlongan CV. (2013) Vasculogenesis in experimental stroke after human cerebral endothelial cell transplantation. Stroke. 44(12): 3473-3481.
  5. Yu S, Tajiri N, Franzese N, Franzblau M, Bae EC, Platt S, Kaneko Y, Borlongan CV. (2013) Stem cell-like dog placenta cells afford neuroprotection against ischemic stroke model via heat shock protein upregulation. PLoS One.8(9):e76329.
  6. Tajiri N, Kaneko Y, Shinozuka K, Ishikawa H, Yankee E, McGrogan M, Case C, Borlongan CV. (2013) Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site. PLoS One.8(9):e74857.
  7. Ishikawa H, Tajiri N, Vasconcellos J, Kaneko Y, Mimura O, Dezawa M, Borlongan CV. (2013) Ischemic stroke brain sends indirect cell death signals to the heart. Stroke. 44(11):3175-3182.
  8. Garbuzova-Davis S, Rodrigues MCO, Hernandez-Ontiveros DG, Tajiri N, Frisina-Deyo A, Boffeli SM, Abraham JV, Pabon MM, Wagner A, Ishikawa H, Shinozuka K, Haller E, Sanberg PR, Kaneko Y, Borlongan CV. (2013) Blood-brain barrier alterations provide evidence of subacute diaschisis in an ischemic stroke rat model. PLoS One. 8(5):e63553.
  9. Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Grimmig B, Diamond DM, Sanberg PR, Bickford PC, Kaneko Y, Borlongan CV. (2013) Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model.PLoS One. 8(1):e53376.

2012年

  1. Kaneko Y, Tajiri N, Yu S, Hayashi T, Stahl CE, Bae EC, Mestre H, Franzese N, Rodrigues AA Jr, Rodrigues MC, Ishikawa H, Shinozuka K, Hethorn W, Weinbren NL, Glover LE, Tan J, Achyuta AH, van Loveren H, Sanberg PR, Shivsankar S, Borlongan CV. (2012) Nestin overexpression precedes caspase-3 upregulation in rats exposed to controlled cortical impact traumatic brain injury.
    Cell Medicine. 4(2):55-63.
  2. Kaneko Y, Tajiri N, Su TP, Wang Y, Borlongan CV. (2012) Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro: role of the opioid system.
    PLoS One    . 7(10):e47583.
  3. Tajiri N, Acosta SA, Glover LE, Bickford PC, Jacotte Simancas A, Yasuhara T, Date I, Solomita MA, Antonucci I, Stuppia L, Kaneko Y, Borlongan CV. (2012) Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats.
    PLoS One. 7(8):e43779.
  4. Arendash GW, Mori T, Dorsey M, Gonzalez R, Tajiri N, Borlongan CV. (2012) Electromagnetic treatment to old Alzheimer's mice reverses β-amyloid deposition, modifies cerebral blood flow, and provides selected cognitive benefit.PLoS One. 7(4):e35751.
  5. Glover LE, Tajiri N, Lau T, Kaneko Y, van Loveren H, Borlongan CV. (2012) Immediate, but not delayed, microsurgical skull reconstruction exacerbates brain damage in experimental traumatic brain injury model.
    PLoS One. 7(3):e33646.

2011年

  1. Wang F, Kameda M, Yasuhara T, Tajiri N, Kikuchi Y, Liang HB, Tayra JT, Shinko A, Wakamori T, Agari T, Date I. (2011) GDNF-pretreatment enhances the survival of neural stem cells following transplantation in a rat model of Parkinson’s disease. Neuroscience Research. 71(1):92-98.
  2. Kaneko Y, Hayashi T, Yu S, Tajiri N, Bae EC, Solomita MA, Chheda SH, Weinbren NL, Parolini O, Borlongan CV. (2011) Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: A new perspective to neuroprotection.Journal of Pineal Research. 50(3):272-280.
  3. Morimoto T, Yasuhara T, Kameda M, Baba T, Kuramoto S, Kondo A, Takahashi K, Tajiri N, Wang F, Jing M, Yuan WJ, Kadota T, Maruo T, Kinugasa K, Miyoshi Y, Shingo T, Borlongan CV, Date I. (2011) Striatal stimulation nurtures endogenous neurogenesis and angiogenesis in chronic-phase ischemic stroke rats.
    Cell Transplantation. 20(7):1049-1064.
  4. Kikuchi Y, Yasuhara T, Agari T, Kondo A, Kuramoto S, Kameda M, Kadota T, Baba T, Tajiri N, Wang F, Tayra JT, Liang HB, Miyoshi Y, Borlongan CV, Date I. (2011) Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion. Journal of Cellular Physiology. 226(5):1390-1398.

2010年

  1. Ou Y, Yu S, Kaneko Y, Tajiri N, Bae EC, Chheda SH, Stahl CE, Yang T, Fang L, Hu K, Borlongan CV, Yu G. (2010) Intravenous infusion of GDNF gene-modified human umbilical cord blood CD34+ cells protects against cerebral ischemic injury in spontaneously hypertensive rats. Brain Research. 1366:217-225.
  2. Masuda T, Maki M, Hara K, Yasuhara T, Matsukawa N, Yu S, Bae EC, Tajiri N, Chheda SH, Solomita MA, Weinbren NL, Kaneko Y, Kirov SA, Hess DC, Hida H, Borlongan CV. (2010) Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse.Brain Research. 1355:228-239.
  3. Bachstetter AD, Jernberg J, Schlunk A, Vila JL, Hudson C, Cole MJ, Shytle RD, Tan J, Sanberg PR, Sanberg CD, Borlongan CV, Kaneko Y, Tajiri N, Gemma C, Bickford PC. (2010) Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.PLoS One. 5(5):e10496.
  4. Wang F, Yasuhara T, Shingo T, Kameda M, Tajiri N, Yuan WJ, Kondo A, Kadota T, Baba T, Tayra JT, Kikuchi Y, Miyoshi Y, Date I. (2010) Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: Focusing on neuroprotective effects of stromal cell-derived factor-1α. BMC Neuroscience. 11:52.
  5. Tajiri N, Yasuhara T, Shingo T, Kondo A, Yuan WJ, Kadota T, Wang F, Baba T, Tayra JT, Morimoto T, Jing M, Kikuchi Y, Kuramoto S, Agari T, Miyoshi Y, Fujino H, Obata F, Takeda I, Furuta T, Date I. (2010) Exercise exerts neuroprotective effects on Parkinson’s disease model of rats. Brain Research. 1310:200-207.

2010年以前の主な論文

  1. Baba T, Kameda M, Yasuhara T, Morimoto T, Kondo A, Shingo T, Tajiri N, Wang F, Miyoshi Y, Borlongan CV, Matsumae M, Date I. (2009) Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/Akt signaling pathway.Stroke. 40(11):e598-605.
  2. Jing M, Shingo T, Yasuhara T, Kondo A, Morimoto T, Wang F, Baba T, Yuan WJ, Tajiri N, Uozumi T, Murakami M, Tanabe M, Miyoshi Y, Zhao S, Date I. (2009) The combined therapy of intrahippocampal transplantation of adult neural stem cells and intraventricular erythropoietin-infusion ameliorates spontaneous recurrent seizures by suppression of abnormal mossy fiber sprouting.Brain Research. 1295:203-217.
  3. Kadota T, Shingo T, Yasuhara T, Tajiri N, Kondo A, Morimoto T, Yuan WJ, Wang F, Baba T, Tokunaga K, Miyoshi Y, Date I. (2009) Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson's disease model of rats with enhanced neurogenesis.
    Brain Research. 1254:120-127.
  4. Yuan WJ, Yasuhara T, Shingo T, Muraoka K, Agari T, Kameda M, Uozumi T, Tajiri N, Morimoto T, Jing M, Baba T, Wang F, Liang HB, Matsui T, Miyoshi Y, Date I. (2008) Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons.BMC Neuroscience. 9:75.