研究業績
＜原著論文＞ (since 2017)
[2023]
Hiroaki Kito*, Reiko Kawagishi, Takusei Ryu, Kyoko Endo, Junko Kajikuri,
Wayne R. Giles, Susumu Ohya
KCa3.1 regulates cell cycle progression by modulating Ca2+ signaling in murine preosteoblasts
J Pharmacol Sci. 153, 142-152 (2023).
Susumu Ohya*, Junko Kajikuri, Hiroaki Kito, Miki Matsui
Down-regulation of CYP3A4 by the inhibition of the KCa1.1 K+channel is responsible for overcoming resistance to doxorubicin in cancer
spheroid models
Int J Mol Sci. 24, 15672 (2023).
Masanori Fujii*, Shuhei Kobayashi, Ayane Ueda, Misaki Sakagami, Rieko Matsui,
Yumeka Yamada, Takeshi Nabe, Susumu Ohya
STIM/Orai-mediated calcium entry may elicit spontaneous thymic stromal
lymphopoietin overproduction in epidermal cells of atopic dermatitis mice
Explor Immunol. 3, 174-185 (2023).
[2022]
Miki Matsui, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Susumu Ohya*
KCa3.1 inhibition-induced activation of the JNK/c-Jun signaling pathway enhances
IL-10 expression in peripherally-induced regulatory T cells
J Pharmacol Sci. 148, 1-5 (2022).
Masanori Fujii*, Shota Imahori, Misao Nakayama, Takeshi Nabe, Susumu Ohya
Tacrolimus suppresses itch-related response in diet-induced atopic dermatitis
model mice by reducing chloroquine-sensitive sensory neurons
Itch. 7, e62 (2022).
Gwangdong Kim, Saotomo Itoh*, Yuma Ito, Susumu Ohya, Shigeaki Hida
Identification of responsible amino acid residues in Staphylococcal superantigen-like
12 for the activation of mast cells
Genes Cells. 27(9), 559-567 (2022).
Susumu Ohya*, Miki Matsui, Junko Kajikuri, Hiroaki Kito, Kyoko Endo
Down-regulation of IL-8 and IL-10 by the activation of Ca2+-activated K+ channel KCa3.1 in THP-1-derived M2 macrophages
Int J Mol Sci. 23(15), 8603 (2022).
[2021]
Susumu Ohya*, Miki Matsui, Junko Kajikuri, Kyoko Endo, Hiroaki Kito
Increased interleukin-10 expression by the inhibition of Ca2+-activated K+ channel KCa3.1 in CD4+CD25+regulatory T cells in the recovery phase in an inflammatory bowel disease
mouse model.
J Pharmacol Exp Ther. 377, 75-85 (2021).
Susumu Ohya*, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Elghareeb E. Elboray,
Takayoshi Suzuki
Ca2+-activated K+channel KCa1.1 as a therapeutic target to overcome chemoresistance in three-dimensional
sarcoma spheroid models
Cancer Sci. 112, 3769-3783 (2021).
Susumu Ohya*, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Miki Matsui
KCa1.1 K+ channel inhibition reverses resistance to antiandrogens in human prostate
cancer LNCaP spheroid model
Int J Mol Sci. 22, 13553 (2021).
[2020]
Hiroaki Kito*, Haruka Morihiro, Yuka Sakakibara, Kyoko Endo, Junko Kajikuri,
Takayoshi Suzuki, Susumu Ohya*
Downregulation of the Ca2+-activated K+ channel KCa3.1 in mouse preosteoblast cells treated with vitamin D receptor agonist.
Am J Physiol Cell Physiol. 319, C345-C358 (2020).
Kyoko Endo, Hiroaki Kito, Ryo Tanaka, Junko Kajikuri, Satoshi Tanaka, Elghareeb
E. Elboray, Takayoshi Suzuki, Susumu Ohya*
Possible contribution of inflammation-associated hypoxia to increased K2P5.1 K+ channel expression in CD4+ T cells of the mouse model for inflammatory bowel disease.
Int J Mol Sci. 21, 38 (2020).
Susumu Ohya*, Katsunori Ito, Noriyuki Hatano, Akitoshi Ohno, Katsuhiko
Muraki, Yuji Imaizumi*
Castration induces down-regulation of A-type K+ channel in rat vas deferens smooth muscle
Int J Mol Sci. 20, 4073 (2019).
Matsui M, Kajikuri J, Kito H, Endo K, Hasegawa Y, Murate S, Ohya S*
Inhibition of interleukin 10 transcription through SMAD2/3 signaling pathway
by Ca2+-activated K+ channel KCa3.1 activation in human lymphoma HuT-78 cells
Mol Pharmacol. 95, 294-302 (2019).
Saeki T, Kimura T, Hashidume K, Murayama T, Yamamura H, Ohya S, Suzuki
Y, Nakayama S, Imaizumi Y*
Conversion of Ca2+ oscillation into propagation electrical signals by Ca2+-activated ion channels and connexin as a reconstituted Ca2+-clock model for the pacemaker activity
Biochem Biophys Res Commun. 510, 242-247 (2019).
Fujii M*, Ohgami S, Asano E, Nakayama T, Toda T, Nabe T, Ohya S
Brain allopregnanolone induces marked scratching behavior in diet-induced
atopic dermatitis mouse model
Sci Rep. 9, 2364 (2019).
[2018]
Matsui M, Terasawa K, Kajikuri J, Kito H, Endo K, Jaikhan P, Suzuki T,
Ohya S*
Histone deacetylases enhance Ca2+-activated K+ channel KCa3.1 expression in murine inflammatory CD4+ T cells
Int J Mol Sci. 19, E2942 (2018)
Fujii M*, Takeuchi K, Umemura Y, Takeuchi M, Nakayama T, Ohgami S, Asano
E, Nabe T, Ohya S
Barbiturates enhance itch-associated scratching in atopic dermatitis mice:
a possible clue to understanding nocturnal pruritus in atopic dermatitis
Eur J Pharmacol. 836, 57-66 (2018)
Khatun A, Shimozawa M, Kito H, Kawaguchi M, Fujimoto M, Ri M, Kajikuri
J, Niwa S, Fujii S, Ohya S*
Transcriptional repression and protein degradation of Ca2+-activated K+ channel KCa1.1 by androgen receptor inhibition in human breast cancer cells
Front Physiol. 9, 312 (2018)
Matsuki K, Katoh D, Takemoto M, Suzuki Y, Yamamura H, Ohya S, Takeshima
H, Imaizumi Y*
Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth
muscle
Am J Physiology Cell Physiol. 315, C1-C9 (2018)
Hatano N, Ohya S, Imaizumi Y, Clark RB, Belke D, Giles WR*
ATP increases [Ca2+]iand activates a Ca2+-dependent Cl-current in rat ventricular fibroblasts
Exp Physiol. 103, 666-682 (2018)
Fujii M*, Ohyanagi C, Kawaguchi N, Matsuda H, Miyamoto Y, Ohya S, Nabe
T
Eicosapentaenoic acid ethyl ester ameliorates atopic dermatitis-like symptoms
in special diet-fed hairless mice, partly by restoring covalently bound
ceramides in the stratum corneum
Exp Dermatol. 27, 837-840 (2018)
Fujimoto M, Kito H, Kajikuri J, Ohya S
Transcriptional repression of HER2 by ClC-3 Cl-/H+ transporter inhibition in human breast cancer cells
Cancer Sci. 109, 2781-2791 (2018)
[2017]
Barrese V*, Cidad P, Yeung SY, López-López JR, McNeish A, Ohya S, Pérez-García
MT, Greenwood IA
Proliferative role of Kv11 channels in murine arteries
Front Physiol. 8, 500 (2017)
Ogiwara K, Ohya S, Suzuki Y, Yamamura H, Imaizumi Y*
Upregulation of voltage-gated, delayed rectifier Kv2.1 K+ channel in renal arterial myocytes of Dahl salt-sensitive rat
Biol Pharm Bull. 40, 1468-1474 (2017)
Hori E, Kikuchi C*, Nagami C, Kajikuri J, Itoh T, Takeuchi M, Matsunaga
T
Role of glyceraldehyde-derived AGEs and mitochondria in superoxide production
in femoral artery of PLETF rat and effects of pravastatin
Biol Pharm Bull. 40, 1903-1908 (2017)
Sakamoto K, Suzuki Y, Yamamura H, Ohya S, Muraki K, Imaizumi Y*
Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated
K+ channels
J Pharmacol Sci. 133, 223-231 (2017)
Matsuki K, Takemoto M, Suzuki Y, Yamamura H, Ohya S, Takeshima H, Imaizumi
Y*
Ryanodine receptor type 3 does not contribute to contractions in the mouse
myometrium regardless of pregnancy
Pflugers Arch - Eur J Physiol. 469, 313-326 (2017)
Fujimoto M, Inoue T, Kito H, Niwa S, Suzuki T, Muraki K, Ohya S*
Transcriptional repression of HER2 by ANO1 Cl-channel inhibition in human breast cancer cells with resistance to trastuzumab
Biochem Biophys Res Commun. 482, 188-194 (2017)
Tabata K, Komori K, Otsuka R, Kajikuri J, Itoh T*
Enhancement of nitric oxide production is responsible for minimal intimal
hyperplasia of autogenous rabbit arterial grafts
Circ J. 81, 1222-1230 (2017)
＜総 説＞ (since 2016)
[2023]
大矢 進*
カルシウム活性化カリウムチャネル阻害による抗がん薬耐性の克服
日本薬理学雑誌, 158, 478-482 (2023).
西山雅祥, 山口陽平, 金子智之, 森松賢順
高圧力顕微鏡による心筋細胞の収縮イメージング
月刊 細胞, 55(14), 1134-1136 (2023)
[2021]
Hiroaki Kito*, Susumu Ohya*
Role of K+ and Ca2+-permeable channels in osteoblast functions
Int J Mol Sci. 221, 459 (2021).
[2019]
大矢 進*，鬼頭宏彰，梶栗潤子
がん創薬標的分子としてのカルシウム活性化カリウムチャネル
日本薬理学雑誌, 154, 108-113 (2019).
大矢 進*
免疫・がん領域におけるイオンチャネル研究の最近の動向
Nagoya Med. J., 56, 131-136 (2019).
[2018]
Ohya S*, Kito H
Ca2+-activated K+ channel KCa3.1 as a therapeutic target for immune disorders.
Biol Pharm Bull. 41(8), 1158-1163 (2018)
[2017]
Niwa S, Khatun A, Ohya S
Potassium ion channels as novel therapeutic targets for the treatment of
advanced and castration-resistant prostate cancers
JAS4QoL. 1-5 (2017).
[2016]
Ohya S, Kito H, Hatano N, Muraki K
Recent advances in therapeutic strategies that focus on the regulation
of ion channel expression. Pharmacol Ther. 160, 11-43 (2016)
＜著 書＞
[2017]
大矢 進
Ⅵ．感覚器・皮膚の疾患と薬（化学構造と薬効）
医療薬学Ⅲ（スタンダード薬学シリーズⅡ-6）, pp. 200-205東京化学同人 (2017).
[2015]
大矢 進
第３章 自律神経系に作用する薬物.
詳解 薬理学, pp. 141-172, 廣川書店 (2015).
＜論 説（Editorial）＞
[2023]
Susumu Ohya*
Recent developments in ion channel and ion-related signaling
Int J Mol Sci. 24, 14419 (2023)
[2022]
Suzuki Y*, Ohya S, Giles WR*
Regulatory mechanisms of Ca2+ activated ion channels and their impact on physiological/pathophysiological
function
Front Physiol. 13, 876327 (2022).
[2020]
Ohya S*, Matsui M, Kajikuri J
Ca2+-activated K+ channel KCa3.1 as a double-edged sword in the treatment of inflammatory bowel disease
J Gastrointestin Liver Dis. 29, 487-489 (2020).
＜その他＞
[2023]
大矢 進，酒井 秀紀
特集：がん悪性化制御に着眼したイオンチャネル・トランスポーター創薬研究の新展開【序文】
日本薬理学雑誌．158, 464 (2023).
山口陽平, 森松賢順
高静水圧で誘発される心筋細胞の緩やかな収縮現象 【トピックス】
生物物理, 63(5), 261-262 (2023)
山口陽平
Afterコロナ，After北海道【AFTERNOON TEA】
日本生理学会雑誌, 85(3), 64-65 (2023)
[2022]
遠藤 京子
肺線維症の線維化促進機構におけるIL-10シグナル伝達【トピックス】
ファルマシア．58, 897 (2022).
大矢 進
五十にして老眼に抗えず【アゴラ】
日本薬理学雑誌．157, 221-212 (2022).
遠藤 京子
肺線維症におけるTh2サイトカイン【最近の話題】
日本薬理学雑誌．157, 86 (2022).
[2019]
大矢進，加藤伸一
イオンチャネル・トランスポーターを標的としたがん創薬研究の新展開－序文－
日薬理誌, 154, 91 (2019)