業績集

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List of publications(2000-2019)


2000

1. Asamoto, M., Ochiya, T., Toriyama-Baba, H., Ota, T., Sekiya, T., Terada, M. and Tsuda, H.
Transgenic rats carrying human c-Ha-ras proto-oncogenes are highly susceptible to N-methyl-N-nitrosourea mammary carcinogenesis. Carcinogenesis, 21(2):243-249, 2000.
2. Ota, T., Asamoto, M., Toriyama-Baba, H., Ochiya, T., Akaza, H., Sekiya, T., Terada, M. and Tsuda, H.
Transgenic rats carrying copies of human c-Ha-ras proto-oncogene exhibit enhanced susceptibility to N-butyl-N(4-hydroxybutyl)nitrosamine bladder carcinogenesis. Carcinogenesis, 21(7):1391-1396, 2000.
3. Tanaka, T., Kawabata, K., Kohno, H., Honjo, S., Murakami, M., Ota, T. and Tsuda, H.
Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.Jpn. J. Cancer Res., 91: 25-33, 2000.
4. Krutovskikh, V. K., Troyanovsky, S. M., Piccoli, C., Tsuda, H., Asamoto, M. and Yamasaki, H.
Differential effect of subcellular localization of communication impairing gap junction protein connexin43 on tumor cell growth in vivo. Oncogene,19: 505-513, 2000.
5. Tanaka, T., Kawabata, K., Kohno, H., Honjo, S., Murakami, M., Shimada, R., Kagami, S. and Tsuda, H.
Bovine lactoferrin inhibits rat tongue carcinogenesis. Shimazaki, k., Tsuda, H., Tomita, M., Kuwata, T., Perraudin, J. (eds.) In: Lactoferrin: Structure, Function and Applications, Elsevier Science, Tokyo, pp: 401-411, 2000.
6. Shimizu, N., Ikehara, Y., Nozaki, K., Kaminishi, M., Tsuda, H., Sugiyama, A., Katsuyama, T. and Tatematsu, M.
Effects of lactoferrin administration in helicobacter pylori infection animal model. K. Shimazaki et al. (eds.) In: Lactoferrin: Structure, Function and Applications, Elsevier Science, Tokyo, pp: 209-215, 2000.
7. Tsuda, H., Sekine, K., Ushida, Y., Kuhara, T., Takasuka, N., Iigo, M., Han, B. S. and Moore M. A.
Milk and dairy products in cancer prevention: focus on bovine lactoferrin. Mutation Res., 462: 227-233, 2000
8. Masuda, C., Wanibuchi, H., Sekine, K., Yano, Y., Otani, S., Kishimoto, T., Tsuda, H. and Fukushima, S.
Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis. Jpn. J. Cancer Res., 91: 582-588, 2000.
9. Wang, W. P., Iigo, M., Sato, J., Sekine, K., Adachi, I. and Tsuda, H.
Activationof intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn. J. Cacer Res.,91: 1022-1027, 2000.
10. Maeda, M., Iigo, M., Tsuda, H., Fujita, H., Yonemura, Y., Nakagawa, K., Endo, Y. and Sasaki, T.
Antimetastatic and antitumor effects of 2.4-diamino-6-(pyridine-4-yl)-1,3,5-triazine (4PyDAT) on the high lung metastatic colon 26 tumor in mice. Anti-Cancer Drug Design, 15: 217-223, 2000.
11. Goldberg, G.S., Bechberger, J. F., Tajima, Y., Merritt, M., Omori, Y., Gawinowicz, M. A., Narayanan, R., Tan, Y., Sanai, Y., Yamasaki, H., Naus, C. C. G., Tsuda, H. and Nicholson, B. J.
Connexin43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells. Cancer Res., 60: 6018-6026, 2000.
12. Tsuda, H., Sekine, K., Takasuka, N., Toriyama-Baba, H. and Iigo, M.
Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals. Flohé, L., Niki, E., Whelan, J. (eds.) In: Bio Factors, IOS Press, vol: 12, pp: 83-88, 2000.
13. Kim, D. J., Takasuka, N., Nishino, H. and Tsuda, H.
Chemoprevention of lung cancer by lycopene. Flohé, L., Niki, E., Whelan, J. (eds.) In: Bio Factors, IOS Press, vol: 13, pp: 95-102, 2000.
14. Tsuda, H., Sekine, K.
Milk components as cancer chemopreventive agents. Asian Pacific J. of Cancer Prev.,1: 277-282, 2000.
15. Park, C. B., Kim, D. J., Moore, M. A., Takasuka, N. and Tsuda, H.
Promotion of liver lesion development in the syrian hamster by dietary fat following multi-organ initiation is inhibited by DHEA-S administration. Asian Pacific J. of Cancer Prev.,1: 329-332, 2000.
16. Kuhara, T., Iigo, M., Itoh, T., Ushida, Y., Sekine, K., Terada, N., Okamura, H. and Tsuda, H.
Orally Administered Lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutrition and Cancer,38(2), 192-199, 2000.
17. Tsuda, H., Seikine, Y., Ushida, Y., Kufara, T., Takasuka, N., Iigo, M., Toriyama- Baba, H. and Goldberg, G.S.
Prevention of carcinogenesisi and metastasis by dietary bovine lactoferrin. Shimazaki,K., Tsuda, H., Tomita, M., Kuwata, T., Perrudin, J., (eds.) In: Lactoferrin: structure, Function and Applications, Elsevier Science, Tokyo, 389-399, 2000.

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2001

1. Tokuzen, R., Iwahori, Y., Asamoto, M., Iigo, M., Hasegawa, F., Satoh, T., Ishidate, M. Jr. and Tsuda, H.
Establishment and characterization of three new rat renal cell carcinoma cell lines from N-ethyl-N-hydroxyethylnitrosamine-induced basophilic cell tumors. Pathol. International, 51: 65-71, 2001.
2. Goldberg,G. S., Jin, Z., Ichikawa, H., Naito, A., Ohki, M., El-Deiry, S. W., Tsuda H.
Global effects of anchorage on gene expression during mammary carcinoma cell growth reveal role of tumor necrosis factor-related apoptosis-inducing ligand in anoikis. Cancer Res.61: 1334-1337, 2001.
3. Han, B. S., Park, C. B., Takasuka, N., Naito, A., Sekine, K., Nomura, E., Taniguchi, H., Tsuno, T.. and Tsuda, H.
A ferulic acid derivative,ethyl 3-(4'-geranyloxy3-methoxyphenyl)-2-propenoate, as a new candidate chemopreventive agent for colon carcinogenesis in the rat. Jpn.J. Cancer Rs., 92: 404-409, 2001
4. Tsuda, H., Asamoto, M., Ochiya, T., Toriyama-Baba, H., Naito, A., Ota, T., Sekiya, T. and Terada, M.
High susceptibility of transgenic rats carrying the human c-Ha-ras proto-oncogene to chemically-induced mammary carcinogenesis. Mut.. Res, 477: 173-182, 2001.
5. Fukamachi, K., Matsuoka, Y., Kitanaka, C., Kuchino, Y. and Tsuda, H.
Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. Biochemical and Biophysical Research Communications, 287: 257-263, 2001.
6. Toriyama-Baba, H., Iigo, M., Asamoto, M., Iwahori, Y., Park, C. B., Han, B. S., Takasuka, N., Kakizoe, T., Ishikawa, C., Yazawa, K., Araki, E., Tsuda, H.
Organotropic chemopreventive effects of n-3 unsaturated fatty acids in a rat multi-organ carcinogenesis model. Jpn. J. Cancer Res., 92:1175-1183, 2001.
7. Chewonarin, T., Kuwahara, T., Arimochi, H., Kataoka, K., Nakayama, H., Yu, D.Y., Tsuda, H., Vinitketkumnuen, U. and Ohnishi, Y.
Epression of human lactoferrin in bacteroides uniformis and its effect on azoxymethane-induced aberrant crypt focus formation in the rat colon. Anaerobe, 7: 247-253, 2001.
8. Tsuda, H., Malcolm, A. Moore.
Cancer screening: A review with particular attention to areas for future international research efforts. Asian Pacific J. of Cancer Prev.,13: 99-123, 2001.

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2002

1. Asamoto, M., Ota, T., Toriyama-Baba, H., Hokaiwado, N., Naito, A. and Tsuda, H.
Mammary carcinomas induced in human c-Ha-ras proto-oncogene transgenic rats are estrogen-independent, but responsive to d-limonene treatment. Jpn. J. Cancer Res.,93: 32-35, 2002.
2. Takasuka, N., Naito, A., Fukamachi, K., Murakoshi, M., Nishino, H. and Tsuda, H.
Modifying effects of carotenoids in a rat multi-organ carcinogenesis model-inhibition in the liver but promotion of lung tumor development- Proc. Jpn. Acad., 78: 33-38, 2002.
3. Tsuda, H., Sekine, K., Fujita, K. and Iigo, M.
Cancer prevention by bovine lactoferrin and underlying mechanisms - a review of experimental and clinical studies. Biochem. Cell. Biol., 80: 131-136, 2002.
4. Fujita, K., Ohnishi, T., Sekine, K., Iigo, M. and Tsuda, H.
Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats. Jpn. J. Cancer Res.,93: 616-625, 2002.
5. Asamoto, M., Toriyama-Baba, H., Ohnishi, T., Naito, A., Ota, T., Ando, A., Ochiya, T. and Tsuda, H.
Transgenic rats carrying human c-Ha-ras proto-oncogene are highly susceptible to N-nitrosomethylbenzylamine induction of esophageal tumorigenesis. Jpn. J. Cancer Res., 93: 744-751. 2002.
6. Han, B. S., Fukamachi, K., Takasuka, N., Ohnishi, T., Maeda, M., Yamasaki, T. and Tsuda, H.
Inhibitory effects of 17β-estradiol and 4-n-octylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats. Carcinogenesis, 23(7): 1209-1215, 2002.
7. Mitsumori, K., Yoshida, M., Iwata, H., Katsuda, O., Kouchi, M. and Tsuda, H.
Classification of renal proliferative lesions in rats and/or mice and their diagnostic problems: report from the working group of the Japanese society of toxicologic pathology. J. Toxicol. Pathol., 15: 175-190, 2002.
8. Kimura, K., Nakano, T., Park, Y. B., Tani, M., Tsuda, H., Beppu, Y., Moriya, H. and Yokota, J.
Establishment of human osteosarcoma cell lines with high metastatic potential to lungs and their utilities for therapeutic studies on metastatic osteosarcoma. Clinical & Experimental Metastasis, 19: 477-485, 2002.
9. Fukamachi, K., Matsuoka, Y., Ohno, H., Hamaguchi, T., and Tsuda, H.
Neuronal leucine-rich repeat protein-3 amplifies MAP kinase activation by EGF through a carboxyl-terminal region containing endocytosis motifs. J. Biol. Chem., 277: 43549-43552, 2002.
10. Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M., Furukawa, F., Wakabayashi, K. and Totsuka, Y.
Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine. Jpn. J. Cancer Res., 93: 1076-1082, 2002.
11. Kohno, H., Tanaka, T., Kawabata, K., Hirose, Y., Sugie, S., Tsuda, H. and Mori, H.
Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats. Int. J. Cancer, 101: 461-468, 2002.
12. Doungchawee, G., Khoaprasert, Y., Kongtim, S., Thamavit, W., Tajima, K., Moore, M.A. and Tsuda, H.
Use of wild rodents for environmental monitoring - comparison of rats in Bangkok and rural areas of Thailand. Asian Pacific J Cancer Prev.,3: 367-3688, 2002.
13. Tajima, K., Tsuda, H. and Moore, M.A.
The contribution of Asian countries to the international cancer prevention effort-reflections from a glance at the literature. Asian Pacific J.Cancer Prev. 3: 1-2, 2002.
14. Tajima, K., Tsuda, H. and Moore, M.A.
Requirement for Asian Pacific collaboration in assessment of nutritional factors impacting on cancer development. Asian Pacific J. Cancer Prev.,3: 93-96, 2002.
15. Tsuda, H., Moore, M.A.
Cancer screening: a review with particular attention to areas for future international research efforts. Asian Pacific J. Cancer Prev.,3: 99-123, 2002.
16.Moore, M.A., Tsuda, H.
Food and play preferences - does cancer prevention require targeting the child? Asian Pacific J. Cancer Prev.3: 279-80, 2002.
17. Moore, M.A, Tsuda, H.
Smoking-related research in the Asian-Pacific countries. Asian Pacific J. Cancer Prev.,3: 291-304, 2002.

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2003

1. Tsuda, H., Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Imaida, K., Tatematsu, M., Hirose, M., Wakabayashi, K. and Moore, M.A.
Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. Toxicol. Pathol., 31: 80-86, 2003.
2. Tanaka, T., Kohno, H., Nomura, E., Taniguchi, H., Tsuno, T. and Tsuda, H.
A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue. Oncology, 64:166-175, 2003.
3. Moore, M.A., Tajima, K. and Tsuda, H.
Epidemiology of the major cancers in the Asian Pacific. Proc. Jpn. Acad.,79: 27-33, 2003.
4. Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Takasuka, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M. and Furukawa, F.
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett., 191: 35-40, 2003.
5. Moore,M.A., Tsuda, H.
Targeting the workplace for cervical and mammary cancer screening? Asian Pacific J Cancer Prev.,4: 1-2, 2003.
6. Fukushima, S., Moore, M.A., Tsuda, H.
Appropriate models and an understanding of carcinogenic mechanisms-requirements for hazard risk assessment. Asian Pacific J. Cancer Prev.,4: 75-78, 2003.
7. Moore, M.A., Kunimoto, T., and Tsuda, H.
Cancer screening literature in the period 2000-2002: Pointers to future research avenues. Asian Pacific J. Cancer Prev.,4: 57-60, 2003.
8. Tsuda, H., Naito, A., Kim, C.K., Fukamachi, K., Nomoto, H. and Moore, M.A.
Carcinogenesis and its modification by environmental endocrine disruptors: In vivo experimental and epidemiological findings. Jpn. J. Clin. Oncol., 33: 259-270, 2003.
9. Matsuoka, Y., Fukamachi, K., Hamaguchi, T., Toriyama-Baba, H., Kawaguchi, H., Kusunoki, M., Yoshida H., and Tsuda, H.
Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: possible application for screening of chemopreventive agents. Toxicol. Pathol., 31: 632-637, 2003.
10. Moore, M.A., Qiao, Y.L., Threlfall, T.J.,Tokudome, S., Tsuda, H. and Tajima, K.
The APOCP/APJCP-taking stock and planning for the future. Asian Pacific J Cancer Prev. 4: 79-80, 2003.
11. Chaimuangraj, S., Thamavit, W., Tsuda, H. and Moore, M.A.
Experimental investigation of opisthorchiasis-associated cholangiocarcinoma induction in the syrian hamster-pointers for control of the human disease. Asian Pacific J Cancer Prev.,4: 87-93, 2003.
12. Moore, M.A., Tsuda, H.
Can risk assessment and chemoprevention research rely on surrogates for tumour yield? Asian Pacific J Cancer Prev.,4: 167-168, 2003.
13. Moore, M.A., Tajima, K., Anh, P.H., Aydemir, G., Basu, P.S., Bhurgri, Y., Chen, K., Gajalakshmi, V., Hirose, K., Mosavi-Jarrahi, A., Ngoan, L.T., Qiao, Y.L., Shin, H.R., Sriamporn, S., Srivatanakul, P., Tokudome, S., Yoo, K.Y. and Tsuda, H.
Grand challenges in global health and the practical prevention program? Asian focus on cancer prevention in females of the developing world. Asian Pacific J. Cancer Prev. 4: 153-165, 2003.
14. Goldberg, G.S., Alexander, D.B., Pellicena, P., Zhang, Z-Y., Tsuda, H. and Miller, W.T.
Src phosphorylates cas on tyrosine 253 to promoto migration of transformed cells. J. Biol. Chem., 278: 46533-46540, 2003.
15. Hokaiwado, N., Asamoto, M., Cho, Y-M., Tsuda, H. and Shirai, T.
Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci.,94:1042-1045, 2003.

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2004

1. Hamaguchi, T., Matsuoka, Y., Kawaguchi, H., Fukamachi, K., Takasuka, N., Ueda, S., Shimizu, K., Ohki, M., Kusunoki, M., Sakakura, T., Yoshida, H. and Tsuda, H.
Terminal endbuds and acini as the respective major targets for chemical and sporadic carcinogenesis in the mammary glands of human c-Ha-ras proto-oncogene transgenic rats. Breast Cancer Res. Treat., 83: 43-56, 2004.
2. Iigo, M., Shimamura, M., Matsuda, E., Fujita, K., Nomoto, H., Satoh, J., Kojima, S., Alexander, D.B., Moore, M.A. and Tsuda, H.
Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis. Cytokine, 25: 36-44, 2004.
3. Park, C.B., Fukamachi, K., Takasuka, N., Han, B.S., Kim, C.K., Hamaguchi, T., Fujita, K., Ueda, S. and Tsuda, H.
Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate. Cancer Sci.,95(3): 205-210,2004.
4. Naito, A., Suzuki,A., Ueda, S., Nomoto, H., Toriyama-Baba, H., Asamoto, M., and Tsuda, H.
Preferential mammary carcinogenic effects of 2-amino-1-methl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human c-Ha-Ras proto-oncogene transgenic rats, Cancer Sci., 95(5): 399-403, 2004.
5. Fukamachi, K., Han, B-S., Kim, C-K., Takasuka, N., Matsuoka, Y., Matsuda, E., Yamasaki, T. and Tsuda, H.
Possible Enhancing effects of atrazine and nonylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats, Cancer Sci.,95(5): 404-410, 2004.
6. Alexander, D.B., Ichikawa, H., Bechberger, J.F., Valiunas, V., Ohki, M., Naus, C.C., Kunimoto, T., Tsuda, H., Miller, W.T., Goldberg, G.S.
Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity. Cancer Res., 64(4): 1347-1358, 2004.
7. Shimamura, M., Yamamoto, Y., Ashino, H., Oikawa, T., Hazato, T., Tsuda, H., Iigo, M.
Bovine lactoferrin inhibits tumor-induced angiogenesis. Int J Cancer,111(1): 111-116, 2004.
8. Fujita. K-I, Matsuda, E., Sekine, K., Iigo, M., Tsuda, H.
Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats, Carcinogenesis, 25(8): 1961-1966, 2004.
9. Nozaki, S., Maeda, M., Tsuda, H. and Sledge, G. W., Jr.
Inhibition of breast cancer regrowth and pulmonary metastasis in nude mice by anti-gastric ulcer agent, irsogladine. Breast Cancer Res. Treat. 83: 195-199, 2004.
10. Kohno, H., Suzuki, R., Sugie, S., Tsuda, H. and Tanaka, T.
Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats. Cancer Sci. 95(4): 300-305, 2004.
11. Takahashi, T., Takasuka, N., Iigo, M., Baba, M., Nishino, H., Tsuda, H. and Okuyama, T.
Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. Cancer Sci. 95(5): 448-453, 2004.
12. Fukushima, S., Wanibuchi, H., Morimura, K., Iwai, S., Nakae, D., Kishida, H., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M. and Furukawa, F.
Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine. Toxicol. Sci. 80(1): 109-114, 2004.
13. Tsuda, H., Ohshima, T., Nomoto, H., Fujita, K., Matsuda, E., Iigo M., Takasuka N. and Moore M.A.
Cancer prevention by nutural compounds. Drug Metab. Pharmacokin. 19(4): 245-263, 2004.
14. Fujita, K., Matsuda, E., Sekine, K., Iigo, M., Tsuda, H.
Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat. Cancer Lett.15: 213(1) 21-29, 2004.
15. Nomoto, H., Iigo, M., Hamada, H., Kojima, S. and Tsuda, H.
Chemoprevention of colorectal by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Nurtriton and Cancer, 49(1): 81-88, 2004.
16. Moore, M.A., Tsuda, H., Tajima, K.
Awareness and high relative mortality rates in the asian pacific. Asian Pac. J.Cancer Prev. 5(2):96-117, 2004.

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2005

1. Goldberg, G.S., Kunimoto, T., Alexander, D.B., Suenaga, K., Ishidaate, F., Miyamoto K., Ushijima T., Teng, C.T., Yokota, J., Phta, T. and Tsuda, H.
Full Length and Dalta Lactoferrin Display Differential Cell Localization Dynamics, but do not Act as Tumor Markers or Significantly Affect the Expression of other Genes. Medicinal Chem.1: 57-64, 2005.
2. Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Tsuda, H., Imaida, K., Shirai, T., Tatematsu M., Tsukamoto, T., Hirose, M. and Furukawa, F.
Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transgerase placental form-positive foci, in rat liver. Cancer Lett. 222: 11-15, 2005.
3. Tsuda, H., Fukamachi, K., Ohima, Y., Ueda, S., Matsuoka, Y., Hamaguchi, T., Ohnishi T., Takasuka N. and Naito, A.
High susceptibility of human c-Ha-ras protooncogene transgenic rats to carcinogenesis: A cancer-prone animal model. Cancer Sci. 96(6): 309-316, 2005.
4. Kohno, H., Suzuki, R., Sugie S., Tsuda, H. and Tanaka, T.
Dietary supplementation with silymarin inhibits 3,2'/-dimethyl-4-Aminobiphenyl-induced prostate carchinogenesis in male F344 rats. Clin Cancer Res.11(13): 4962-67, 2005.
5. Iigo, M., Shimamura, M., Hirano, S., Nabeshima, K., Ohkubo, S., Tamura Y. and Tsuda, H.
Cancer prevention and anti-metastatic effect by oral administartion of bovine lactoferrin. In: Takuji Tanaka, Hiroyuki Tsuda eds. Carcinogenesis and Modification of Carcinogenesis, Kerala, India, Research Signpost, 229-241. 2005.
6. Morimura, K., Kang, J.S., Wei, M., Wanibuchi, H., Tsuda, H. and Fukushima, S.
Lack of Urinary Bladder Carcinogenicity of Sodium L-Ascorbate in Human c-Ha-ras Proto-Oncogene Transgenic Rats. Toxicol. Path. 33: 764-767, 2005.

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2006

1. Suzuki, R., Kohno, H., Suzui, M., Yoshimi, N., Tsuda, H., Wakabayashi, K. and Tanaka, T.
An animal model for the rapid induction of tongue neoplasms in human c-ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies. Carcinogenesis. 27(3): 619-630,.2006.
2. Tsuda, H., Fukamachi, K., Jiegou, X., Sekine, K., Ohkubo, S., Takasuka, N. and Iigo, M.
Prevention of carcinogenesis and cancer metastasis by bovine lactoferrin. Proc. Jpn. Acad., Ser.B 82: 208-215, 2006.
3. Ueda, S., Fukamachi, K., Matsuoka, Y., Takasuka, N., Takeshita, F., Naito, A., Iigo, M., Alexander, D.B., Moore, M. A., Saito, I., Ochiya, T., and Tsuda, H.
Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. Carcinogenesis. 27(12): 2497-2510, 2006.
4. Hamaguchi, T., Matsuoka, Y., Bechbeger, J., Ohnishi, T., Fujita, K., Naus, C.C., Kusunoki, M., Tsubura, A. and Tsuda, H.
Establishiment of an apoptosis-sensitve rat mammary carcinoma cell line with a mutation in the DNA-binding region of p53. Cancer Letters. 232: 269-288, 2006.

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2007

1. Onishi, T., Fukamachi, K., Ohshima, Y., Jiegou, Xu., Ueda, S., Iigo, U, Takasuka, N., Naito, A., Fujita K., Matsuoka Y., Izumi K., and Tsuda, H.
Possible application of human c-Ha-ras proto-oncogene transgenic rats in a medium-term bioassay model for carcinogens. Tox. Pathol. 35: 436-443, 2007.
2. Tsuda, H., Iigo, M., Takasuka, N., Ueda, S., Ohshima Y., Fukamachi, K., Shirai, T., Hirano, S., Matsuda, E., and Wakabayashi, K.
Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats. Food and Chem.Toxicology 45: 1013-1019, 2007.
3. Iigo, M,, Shimamura, M., Hirano, S., Tokutake, S., Alexander, D.B. and Tsuda, H. Tanaka, T., (Editor)
Cancer prevention and anti-metastatic effects by oral administration of procyanidins. Cancer: Dosease Progression and Chemoprevention, p.p. 277-297, ISBN:81-308-0150-7, 2007.
4. Naiki-Ito, A., Asamoto, M., Jplaowadp, M., Talajasjo S., Uamashita, H., Tsuda, H., Ogawa, K. and Shirai, T.
Gpx2 Is an Overexpressed Gene in Rat Breast Cancers Induced by Three Different Chemical Carcinogens. Cancer Res 67(23): 11353-11358, 2007.
5. Matsuoka, M., Hamaguchi, T., Fukamachi, K., Yoshida, M., Watanabe G., Taaya, K., Tsuda, H. and Tsubura, A.
Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention. Med Mol Morphol 40: 185-190, 2007.
6. Matsuoka,Y,. Kawaguchi,H., Yoshida,H., Tsuda, H., and Tsubura, A.
Rat mammary preneoplasia and neoplasia: a model for human breast cancer research. Trends in Cancer Reseach. 3: 1-13, 2007.

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2008

1. Matsuoka, M., Fukamachi, K., Uehara, N., Tsuda, H. and Tsubura, A.
Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis. Cancer Sci 99:309-315, 2008.
2. Kurosawa, G., Akahori, Y., Morita, M., Sumitomo, M., Sato, N., Muramatsu, C., Eguchi, K., Matsuda, K., Takasaki, A., Tanaka, M., Iba, Y., Hamada-Tsutsumi, S., Ukai, Y., Shiraishi, M., Suzuki, K., Kurosawa, M., Fujiyama, S., Takahashi, N., Kato, Ryoichi., Mizoguchi, Y., Shamoto, M., Tsuda, H., Sugiura, M., Hattori, Y., Miyakawa, S., Shiroki, R., Hoshinaga, K., Hayashi, N., Sugioka, A. and Kurosawa, Y.
Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic. PNAS 105:7287-7292, 2008.
3. Fukamachi,K., Imada,T., Ohshima,Y., Xu,Jiegou. and Tsuda,H.
Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat. Cancer Sci 99:1841-1846, 2008.
4. Tamano, S., Sekine, K., Takase, M., Yamauchi, K., Iigo, M. and Tsuda, H.
Lack of Chronic Oral Tpxicity of Chemopreventive Bovine Lactoferrin in F344/DuCrj Rats.Asian Pacific J Cancer Prev. 9: 313-316, 2008.
5. Iigo, M., Alexander, D, B., Long, N., Xu, J., Fukamachi, K., Futakuchi, M., Takase, H. and Tsuda, H.
Anticarcinogenesis pathways activated by bovine lactferrin in the murine small intestine. Biochimie. 91:86-101, 2009.
6. Ueda, S., Kawamata, M., Teratani, T., Shimizu, T., Tamai, Y., Ogawa, H., Hayashi, K., Tsuda, H. and Ochiya, T.
Establishment of rat embryonic stem cells and making of chimera rats. PLoS ONE, 3: e2800, 2008.

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2009

1. Kitamura,Y.,Kurosawa,G.,Tanaka,M.,Sumitomo,M.,Muramatsu,C., Eguchi,K.,Akahori,Y.,Iba,Y.,Tsuda,H.,Sugiura,M.,Hattori,Y., Kurosawa,Y.
Frequent overexpression of CADM1/IGSF4 in lung adenocarcinoma. Biochemical and Biophysical Research Coimmunications. 480-484, 2009.
2. Fukamachi, K., Tanaka, H., Hagiwara, Y., Ohara, H., Joh, T., Iigo, M., Alexander, DB., Xu,J., Long, N., Takigahira ,M., Yanagihara,K., Hino, O.,Saito,I., Tsuda,H.
An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas. Biochem Biophys Res Commun. 390: 636-641, 2009.
3. Kozu,T., Inuma, G., Ohashi, Y., Saito ,Y., Akasu, T.,Saito, D., Alexander DB., Iigo, M., Kakizoe ,T., Tsuda, H.
Effect of orally administrated bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial. Cancer Prevention Research(Phila Pa). 2: 975-983, 2009.
4. Grosse Y, Baan R, Straif K, Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Galichet L, Cogliano V;
WHO International Agency for Research on Cancer Monograph Working Group.Collaborators (23)Miller AB, Phillips DH, Kaldor J, Olsen JH, Berger MR, Schmeiser HH, Tsuda H, Kim SH, Baguley BC, Marques M, Karran P, Barrett-Connor E,Beland FA, Bolton JL, Bosland MC, Buell JF, Eastmond D, Jameson CJ, Kaufman DG, Molinolo AA, Schiffer CA, Titus-Ernstoff L, Thomas DB.A review of human carcinogens--Part A: pharmaceuticals. Lancet Oncol., 2009:10(1)13-14.
5. Tsuda, H., Xu, J., Sakai,Y., Ftakuchi, M., Fukamachi, K.
Toxicology of Engineered Nanomaterials-A review of Cacinogenic Potential. Asian Pacific J Cancer Prev. 10: 975-980, 2009.
6. Long, N., Hardiville, S., Pierce, A., Fukamachi, K., Futakuchi, M., Alexander, D.B., Shirai, T. and Tsuda, H.
Construction of a multi-functional helper-dependent adenovirus based system for cancer gene therapy. Asian Pac J Cancer Prev, 10: 939-960, 2009.

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2010

1. Tanaka, H., Fukamachi, K., Futakuchi, M., Alexander, D.B., Long, N., Tamamushi, S., Minami . K., Seino, S., Ohara, H., Joh ,T., Tsuda, H.
Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult rats. Cancer Sci. 101: 341-346, 2010.
2. Sakamoto,Y., Nakae, D., Hagiwara, Y., Satoh, K., Ohashi, N., Fukamachi, K., Tsuda,H., Hirose, A., Nishimura,T., Hino, O., Ogata, A.
Serum ERC/mesothelin level in rats with mesothelial proliferative lesions induced by multi-wall carbon nanotube. Journal of Toxicologic Sciences. 35: 265-270, 2010.
3. Tsuda, H., Futakuchi, M., Fukamachi, K., Shirai, T., Imaida, K., Fukushima, S., Tatematsu, M., Furukawa, F., Tamano S., Ito, N.
A Medium-Term, Rapid Rat Bioassay Model for the Detection of Carcinogenic Potential of Chemicals. Toxicol Pathol. 38:182-187, 2010.
4. Xu, J., Futakuchi. M., Iigo, M., Fukamachi, K., Alexander, D.B., Shimizu.H., Sakai ,Y., Tamano,S., Furukawa, F., Uchino, T., Tokunaga, H., Nishimura, T., Hirose, A., Kanno, J., Tsuda, H.
Involvement of macrophage inflammation protein 1α(MIP1α) in promotion of rat lung and mammary carcinogenic activity of nano-scale titanium dioxide particles administered by intra-pulmonary spraying. Carcinogenesis. 31:927-935, 2010.
5. Tsuda, H.
Risk Assessment Studies of Nanomaterials in Japan and Other Countries. Asian Pacific J Cancer Prev,10, DIMS 30 th Anniverrsary Supplement. 11-12, 2010.
6. Tsuda, H., Kozu, T., Iinuma, G., Ohashi, Y., Saito, D., Akasu, T., Alexander, D.B., Futakuchi, M., Xu, J., Kakizoe, T., Iigou, M.
Cancer prevention by bovine lactoferrin: from animal studies to human trial. Biometals23: 399-409, 2010.
7. Bolon B., Barale-Thomas E., Bradley A., Ettlin RA., Franchi CA., George C., Giusti AM., Hall R., Jacobsen M., Konishi Y., Ledieu D., Morton D., Park JH., Scudamore CL., Tsuda H ., Vijayasarathi SK., Wijnands MV.
International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies. Exp Toxicol Pathol. 2011 Jan;63(1-2):187-95. Epub 2010 Aug 17.
Toxicol Pathol. 2010;38(6):984-92. Epub 2010 Aug 17.
8. Wei M., Wanibuchi H., Nakae D., Tsuda H., Takahashi S., Hirose M., Totsuka Y., Tatematsu M., Fukushima S.
Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f ]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip / WAF1). Cancer Sci. 2011 Jan;102(1):88-94. doi: 10.1111/j.1349-7006.2010.01761.x. Epub 2010 Oct 21.

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2011

1. Xu J., Sagawa Y., Futakuchi M., Fukamachi K., Alexander DB., Furukawa F., Ikarashi Y, Uchino T., Nishimura T., Morita A., Suzui M., Tsuda H.
Lack of promoting effect of titanium dioxide particles on ultraviolet B-initiated skin carcinogenesis in rats. Food Chem Toxicol. 2011 Jun;49(6):1298-302. Epub 2011 Mar 23.
2. Alexander DB., Tsuda H., Iigou M., Xu J., Suzui M., Kozu T., Saito Y., Takase M., Yamauchi K.
Inhibition of colon carcinogenesis in humans by ingested bovine lactoferrin. In: Lactoferrin 2011, pp: 70-77, 2011.

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2012

1. Tsuda H., Iigou M., Alexander DB., Takasuka M., Chuel Kyu Kim., Beom Seok Han., Cheol Beom Park,, Jin Man Kim., Dae Joong Kim., Fukamachi K., Suzui M., Nomura E., Taniguchi H., and Tsuno T.
Comparative study of 10 ferulic acid derivatives for inhibitory potential of colon carcinogenesis in the rat . RICE STUDIES, PRESENT AND FUTURE. In Commemoration of the 2nd International Symposium on Rice and Disease Prevention 2012 Mar ; 86-96.
2. Sagawa Y., Futakuchi M., Xu J., Fukamachi K., Sakai Y., Ikarashi Y., Nishimura T., Suzui M., Tsuda H., and Morita A.
Lack of promoting effect of titanium dioxide particles on chemically-induced skin carcinogenesis in rats and mice.The Journal of Toxicological Sciences. 2012; Vol.37 (2):317-327.
3. Takagi A., Hirose A., Futakuchi M., Tsuda H., and Kanno J.
Dose-dependent mesothelioma induction by intraperitoneal administration of multi-wall carbon nanotubes in p53 heterozygous mice. Histology of a small nodule of moderately to poorly differentiated epithelioid mesothelioma. Cancer Sci. 2012 Aug;103(8):Augustcover. doi: 10.1111/j.1349-7006.2012.02340.x. PMID: 22834693 [PubMed - in process]
4. Alexander DB., Iigo M., Yamauchi K., Suzui M.,and Tsuda H.
Lactoferrin: an alternative view of its role in human biological fluids. Biochem Cell Biol. 2012 Jun;90(3):279-306. Epub 2012 May 3.
5. Xu, J., Futakuchi M., Shimizu H., Alexander DB., Yanagihara K., Fukamachi K., Suzui M., Kanno J., Hirose A., Ogata A., Sakamoto Y., Nakae D., Omori T. and Tsuda H.
"Multi-walled Carbon Nanotubes Translocate into the Pleural Cavity and Cause Hyperplasic Visceral Mesothelial Proliferation." Cancer Science. Vol.103 (12) :2045-2050, 2012.
6. Yoshioka S., Nisimura K., Takemura T., Suzui M., Tsuda H., and Itabashi Y.
Analysis of Enantiomeric Glycidyl Fatty Acid Esters by Chiral-phase HPLC/MS with Atmospheric Pressure Chemical Ionization. BUNSEKI KAGAKU Vol.61 (9) :783-790, 2012.
7. Yabushita S., Fukamachi K., Tanaka H., Sumida K., Deguchi Y., Sukata T., Kawamura S., Uwagawa S., Suzui M., and Tsuda H.
Circulating MicroRNAs in Serum of Human K-ras Oncogene Transgenic Rats With Pancreatic Ductal Adenocarcinomas. Pancreas. ; 41(7):1013-8, 2012 Oct.

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2013

1. Yabushita S., Fukamachi K., Tanaka H., Fukuda T., Sumida K., Deguchi Y., Mikata K., Nishioka K., Kawamura S., Uwagawa S., Suzui M., Alexander DB., and Tsuda H.
Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas. Carcinogenesis. 34(6):1251-1259
2. Yabushita S., Fukamachi K., Kikuchi F., Ozaki M., Miyata K., Sukata T., Deguchi Y., Tanaka H., Kakehashi A., Kawamura S., Uwagawa S., Wanibuchi H., Suzui M., Alexander DB., and Tsuda H.
Twenty-One Proteins Up-Regulated in Human H-ras Oncogene Transgenic Rat Pancreas Cancers are Up-Regulated in Human Pancreas Cancer. Pancreas. 42(6):1034-1039 Aug.
3. Grosse Y, Loomis D, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K;International Agency for Research on Cancer Monograph Working Group.Collaborators (23)Stewart BW, Biggar RJ, Lachenmeier DW, Singh S, Tsuda H, Baguley B, Marques MM, Tseng CH, Knight TL, Beland FA, Betz JM, Carcache de Blanco EJ, Cunningham ML, Dunnick JK, Guo L, Jameson CW, Karagas M, Lunn RM, McCormick DL, Singh S, Witt KL, Zhou S, Stafford RS.
Carcinogenicity of some drugs and herbal products.Lancet Oncol. 2013 Aug;14(9):807-8.
4. Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Guha N, Mattock H, Straif K; International Agency for Research on Cancer Monograph Working Group.Rusyn II, Fritschi L, Sergi CM, Hansen J, Le Curieux F, Bolt HM, Fukushima S, Ichihara G, Kamae K, Kumagai S, Tsuda H, Kjaerheim K, Bartell SM, Cesta MF, Chiu W, Cooper G, DeWitt JC, Friesen M, Lash LH, Steenland K, Cherrie JW.
Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone.Lancet Oncol. 2014 Aug;15(9):924-5.
5. Ohba T., Sagawa E., Suzuki Y., Yamamura H., Ohya S., Tsuda H., and Imaizumi Y.
Enhancement of Ca2+ Influx and Ciliary Beating by Membrane Hyperpolarization due to ATP-Sensitive K+ Channel Opening in Mouse Airway Epthelial Cells. J Pharmacol Exp Ther 347:145-153,2013 Oct.
6. Fukamachi K., Tanaka H., Sakai Y., Alexander DB., Futakuchi M., Tsuda H., Suzui M.
A Novel Reporter Rat Strain That Expresses Lacz Upon Cre-Mediated Recombination. Genesis. 51:268-274, 2013

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2014

1. Xu J., Futakuchi M., Alexander D.B., Fukamachi K., Numano T., Suzui M., Shimizu H., Omori T., Kanno J., Hirose A., and Tsuda H.
Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogensis but cause reversible epithelial hyperplasia of terminal bronchioles. Arch Toxicol., 88(1):65-75 Jan.
http://link.springer.com/article/10.1007/s00204-013-1086-5#page-1
2. Numano T., Xu J., Futakuchi M., Fukamachi K., Alexander D.B., Shimizu H., Furukawa F., Kanno J., Hirose A., Tsuda H., and Suzui M.,
Comparative study of the toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro. APJCP. 15:929-935. 2014.
3. Ohba T., Xu J., Alexander D.B., Yamada A., Kanno J., Hirose A., Tsuda H., and Imaizumi Y.
MWCNT causes extensive damage to the ciliated epithelium of the trachea of rodents. 39(3):499-505.
4. Xu J., Alexander D.B., Futakuchi M., Numano T., Fukamachi K., Suzui M., Omori T., Kanno J., Hirose A. and Tsuda H.
Size- and shape-dependent pleural translocation, deposition, fibrogenesis and mesothelial proliferation by multi-walled carbon nanotubes. Cancer Science.105(7):763-9 2014
5. Iigo M., Alexander D.B., Xu J., Futakuchi M., Suzui M., Kozu T., Akasu T., Saito D., Kakizoe T., Yamaguchi K., Abe F., Takase M., Sekine K., and Tsuda H.
Inhibition of intestinal polyp growth by oral ingestion of bovine lactoferrin and immune cells in the large intesine. BioMetals. 2014 Doi 10. 1007/ s10534-014-9747-2
6. Sakai Y., Fukamachi K., Futakuchi M., Miyoshi I., Tsuda H., Suzui M., and Hayashi H.
A novel transgenic mouse model carrying human tribbles related protein 3(TRB3) gene and its site specific phenotype. Biol Pharm Bull., 37(6) : 1068 – 1074. 2014
7. Alexander D.B., Iigo H., Hamano H., Kozu T., Saito Y., Saito D., Kakizoe T., Xu J., Yamauchi K., Takase M., Suzui M., Tsuda H.
An ancillary study of participants in a randomized, placebo-controlled trial suggests that ingestion of bovine lactoferrin promotes expression of interferon alpha in the human colon. J. Functinal Foods, 10:305-317. 2014
8.Fukamachi, K, Iigo, M., Hagiwara, Y., Shibata, K., Futakuchi, M., Alexander, D. B., Hino, O., Suzui, M., Tsuda, H.,
Rat, N-ERC/Mesothelin as a marker for In vivo Screening of drugs against pancreas cancer PLoS ONE 9(10): e111481. doi:10.1371/journal.pone.0111481, 2014

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2015

1. Xu J., Alexander DB., Iigo M., Hamano H., Takahashi S., Yokoyama T., Kato M., Usami I. , Tokuyama T., Tsutsumi M., Tamura M., Oguri T., Niimi A., Hayashi Y., Yokoyama Y.,Tonegawa K., Fukamachi K., Futakuchi M., Sakai Y., Suzui M., Kamijima M., Hisanaga N., Omori T., Hirose A., Kanno J., Nakae D., and Tsuda H.
Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study. Cancer Sci., 106(7): 825-832, 2015.
2. Shibata K, Fukamachi K, Tsuji A, Saga T, Futakuchi M, Nagino M, Tsuda H, Suzui M.
In vivo 18F-fluorodeoxyglucose-positron emission tomography/computed tomography imaging of pancreatic tumors in a transgenic rat model carrying the human KrasG12V oncogene. Oncol Lett, 9: 2112-2118, 2015.

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2016

1. Suzui M, Futakuchi M, Fukamachi K, Numano T, Abd Elgied M, Takahashi S, Ohnishi M, Omori T, Tsuruoka S, Hirose A, Kanno J, Sakamoto Y, Alexander DB, Xu J, Tsuda H.
Multiwalled carbon nanotubes intratracheally instilletd into the rat lung induce development of pleural malignant mesothelioma and lung tumors. Cancer Sci, doi:10.1111/cas. 12954, 2016.

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2017

1. Magaki M, Ishii H, Yamasaki A, Kitai Y, Kametani S, Nakai R, Alexander DB, Tsuda H, Ohnishi T
A high-fat diet increases the incidence of mammary cancer in c-Ha-ras proto-oncogene transgenic rats, J Toxicol Pathol 2017; 30: 145–152
2. Alexander D., Iigo M., Abdelgied M., Ozeki K., Tanida S., Joh T., Takahashi S., Tsuda H.
Bovine lactoferrin and Crohn’s disease: a case study, Biochemistry ond Cell Biology, 95(1): 133-141, 2017.

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2018

1. Liao D., Wang Q., Alexander D., Abdelgied M., Elgazzar AM., Futakuchi M., Suzui, M., Kannno J., Hirose A., Xu J., Tsuda H.
Persistent Pleural Lesions and Inflammation by Pulmonary Exposure of Multiwalled Carbon Nanotubes, Chem. Res. Toxicol., 15;31(10):1025-1031. 2018.
2. Elgazzar AM., Abdelgied M., Alexander D., Alexander W., Numano T., Iigo M., Naiki A., Takahashi S., Takase H., Hirose A., Kanno J., Elokle OM., Nasem AM., Tsuda H.
Comparative pulmonary toxicity of a DWCNT and MWCNT-7 in rats, Arch. Toxicol., 93: 43-59, 2019
3. Abdelgied M., Elgazzar AM., Alexander D., Alexander W., Numano T., Iigo M., Naiki-Ito A.,Takase H., Abdou KB., Hirose A., Taquahashi Y., Kanno J., Tsuda H.
Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats, Cancer Sci., 109(7):2164-2177, 2018

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2019

1. Abdelgied M.,Elgazzar AM., Alexander D., Alexander W., Numano T., Iigo M., Naiki-Ito A., Takase H., Abdou KB., Hirose A., Taquahashi Y., Kanno J., Abdelhamid M., Tsuda H., Takahashi S.
Pulmonary and pleural toxicity of potassium octatitanate fibers, rutile titanium dioxide nanoparticles, and MWCNT-7 in male Fischer 344 rats, Arch. Toxicol., 93(4): 909-920, 2019
2. Fukamachi, K., Hagiwara Y., Futakuchi M., Alexander DB., Tsuda H., Suzui M.
Evaluation of a biomarker for the diagnosis of pancreas cancer using animal model. J Toxicol. Pathol., 2019
3. Numano T., Higuchi H., Alexander D., Alexander W., Abdelgied M.,Elgazzar AM., Saleh D, Takase H, Hirose A, Naiki-Ito A., Suzuki S., Takahashi S., Tsuda H.
MWCNT-7 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats, Cancer Science, in press , 2019

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業績集 (2000年ー2018年)


2000年

1. 津田洋幸
「発がんとがん予防−がんはどこまで予防できるかー」診療と新薬第37巻4号17-37, 2000
2. 津田洋幸
「ヒト正常型c-Ha-ras遺伝子トランスジェニックラットを用いた食品添加物の発がん性短期検索法の確立」(財)三栄源食品化学研究振興財団第6回研究成果報告書113-115, 2000
3. 津田洋幸、関根一則、飯郷正明、牛田吉彦、久原徹哉
「ラクトフェリンによる大腸がんの化学予防」がん化学予防の最前線76-85, 2000

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2001年

1. 松岡洋一郎、深町勝巳、鳥山一馬場弘康、津田洋幸
「ヒトc-Ha-ras遺伝子トランスジェニックラット由来腫瘍細胞に高発現するRasの標的候補遺伝子ラットNLRR-3の単離と機能解析」乳癌基礎研究 Vol.10:18-22, 2001
2. 津田洋幸
「発がんの化学予防」血液・腫瘍科 42(6) :528-532, 2001
3. 沖田 極、津田洋幸、金子周一、林 紀夫
「肝細胞癌の予防治療」(座談会)肝胆膵 43(3):381-396, 2001

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2002年

1. 松岡洋一郎、川口博明、鳥山一馬場弘康、深町勝巳、吉田浩己、津田洋幸
「ヒト正常型c-Ha-ras遺伝子トランスジェニックラットの乳腺発がん高感受性の機序解析」乳癌基礎研究Vol.11:33-36, 2002
2. 津田洋幸、深町勝巳、徐 結苟、飯郷正明、関根一則、大久保重敏
「多機能蛋白質ウシラクトフェリンによるがん予防の試みFood & Food Ingredients Journal of Japan No.200:27-35, 2002

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2003年

1. 津田洋幸、関根一則、飯郷正明
「ラクトフェリンによる発がん予防とその機序の解析」Food & Food Ingredients Journal of Japan No.200:27-35, 2002
2. 津田洋幸
「がん遺伝子トランスジェニックラットを用いた発がん研究」日病学誌第92貫第2号:21-33, 2003
3. 藤田健一、津田洋幸
「ラクトフェリンの癌化学予防効果とその機序—ヘテロサイクリックアミン誘発肝および大腸発癌に対してー」医学のあゆみVol.204(1):101-104, 2003

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2004年

1. 濱口哲也、松岡洋一郎、高須賀信夫、深町勝巳、吉田浩己、津田洋幸
「ヒト正常型c-Ha-ras遺伝子トランスジェニックラットの乳セイン発がん高感受性の機序解析—化学発がんと自然発がんの比較—」乳癌基礎研究Vol.13:21-28, 2004
2. 津田洋幸
「新しい毒性学と人材育成」名古屋市立大学医学会雑誌第55巻第2号:51-61, 2004
3. 飯郷正明、島村真里子、鍋島かずみ、若林裕之、大久保重敏、田村吉隆、津田洋幸
「ウシラクトフェリンの免疫能増強および血管新生阻害作用による発がん抑制と臨床応用」Milk Science Vol.53(4):273-274, 2004
4. 松田栄治、藤田健一、飯郷正明、若林敬二、津田洋幸
「ヒトラクトフェリンおよびその部分断片ペプチドの細胞内局在」Milk Science Vol.53(4), 2004
5. 大嶋 浩、深町勝巳、松岡洋一郎、濱口哲哉、大西隆仁、高須賀信夫、飯郷正明、内藤暁宏、津田洋幸
「発がん高感受性ヒトc-Ha-ras遺伝子トランスジェニックラットー新規高発がん動物モデルの開発—」第21回日本疾患モデル学会シンポジウム「新しい展開を迎えるラットリソース」講演記録:45-53, 2004

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2005年

1. 津田洋幸、深町勝巳、大嶋 浩、飯郷正明、高須賀信夫、松田栄治、関根一則、大久保重俊、神津隆弘、島村眞里子
「ラクトフェリン「多機能天然由来物質によるがん予防—」がん予防食品開発の新展開」337-346, 2005
2. 津田洋幸
「ラクトフェリン」予防医学事典:166-168, 2005

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2006年

1. 津田洋幸
「日本毒性学の現状と課題」現代医学54巻: 257-266, 2006
2. 津田洋幸、深町勝巳、徐 結苟、David Alexamder、上田しのぶ、田中創始、林 香月、落谷孝広、斉藤 泉
「膵発がん幹細胞候補の同定」第23回日本疾患モデル学会シンポジウム「疾患モデルからヒト発がんの本態解明へ」講演記録:36-42, 2006

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2007年

1. 深町勝巳、松岡洋一郎、津田洋幸
「毒性病理学会の最近の話題 発がん高感受性ラットと毒性学」病理と臨床 Vol.25(8):736-743, 2007

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2008年

1. 津田洋幸、徳永裕司、広瀬明彦、菅野純、
ナノマテリアルの有害性評価(毒性評価)(Hazard Identification of Nanomaterials)、日本薬学会1287年会シンポジウム、2008

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2009年

1. 深町勝巳、田中創始、大原弘隆、津田洋幸
「動物を用いた膵管癌の起始細胞の同定」肝胆膵 59(4):649-656,2009

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2010年

1. 深町勝巳、酒々井眞澄、徐 結苟、津田洋幸
「発がん物質の中期評価代替検索法 Alternative Animal Models for Carcinogenicity Testing -Evaluation of Gene-engineered Models-」Food & Food Ingredients Journal of Japan No.215:390-397,No.4, 2010

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2011年

1. 広瀬明彦、高木篤也、西村哲治、津田洋幸、小縣昭夫、中江 大、樋野興夫、菅野 純
「ナノマテリアルの慢性影響研究の重要性」YAKUGAKU ZASSHI 131(2):195-201,2011

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2016年

1. 津田洋幸
「カーボンナノチューブの肺と胸膜中皮に対する毒性と発がん性の簡易評価法」医学のあゆみ, vol.259 No. 3, 223-227, 2016

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2018年

1. 津田洋幸(環境部・分担執筆)
国立天文台編:化学物質・放射線 環・107-108(1061−1062)理科年表2018, 平成30年第91

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