最新論文
Interaction between the cellular mRNA and the cellular microRNA linked to human immunodeficiency virus latency
Neil Tan Gana, Okamoto T.
Clin Vaccine Immunol. 2013(in press)
ABSTRACT: Although microRNAs (miR/s) play regulatory roles in a wide variety of cellular events, the regulatory mechanisms of miRs associated with viral diseases such as human immunodeficiency virus (HIV-1) infection, the causative agent of acquired immunodeficiency syndrome (AIDS), are largely unknown. In addition, the molecular mechanism of HIV viral latency is not fully understood. Thus, in order to understand the molecular mechanism of viral latency, we have attempted to clarify the role of cellular miR species that are upregulated in the maintenance of viral latency. Based on two previous reports and the data sets of the upregulated cellular miR upon HIV infection, we searched their target cellular mRNAs using an integrated ontology-based rich-text mining algorithm that enables the target identification of miRs. Using this algorithm we have identified four cellular gene modules namely: module 1 (cell cycle regulators) APOBEC7G, EIF5, MAPK, MYB, MYC, NCOA3, NKFB1, NFKBA1, P300, RAS, RAF, SRC1; module 2 (cell transcription factors) CREBBP, STAT1, STAT5A; module 3 (HIV-1 transcription modulators) RUNX1, TFCP2, YY1, and; module 4 (immune response genes) IFNA 1, IL15, IL6, IL2, IL7, IL10. A high stringency miR target analyses of the 3'-untranslated region (3'-UTR) sequences of these target genes identified common, and multiple in some cases, sequences within these modules. We have deciphered multiple gene regulatory networks using relational software STRINGS, which were consistent with previous observations. The findings clearly demonstrate the cross correlations between miR and mRNA in HIV infected cells.
論文リスト
2014
Ito M, Hamano T, Komatsu T, Asamitsu K, Yamakawa T, Okamoto T.
A novel IKKα inhibitor, noraristeromycin, blocks the chronic inflammation associated with collagen-induced arthritis in mice.
Mod Rheumatol. 2014 (in press)
Tan Gana N. H., Okamoto T.
Interaction between the cellular mRNA and the cellular micro RNA linked to human immunodeficiency virus latency.
Nagoya Medical Journal 2014. 54: 33-44
2013
Suzuki T, Kasuya Y, Itoh Y, Ota Y, Zhan P, Asamitsu K, Nakagawa H, Okamoto T, Miyata N.
Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly.
PLoS One. 2013. 8: e68669
Okamoto T.
Dual Use in Pathogen Research.
JDR. 2013. 8：714-716.
Victoriano AF, Imai K, Okamoto T.
The interaction between endogenous bacterial flora and the latent HIV.
Clin Vaccine Immunol. 2013 (in press)
Cueno ME, Imai K, Okamoto T, Ochiai K.
Overlapping glycosylation sequon influences the glycosylation pattern of a chimeric protein expressed in tomato leaf and callus.
J Biotechnol. 164(1):9-12. 2013.
2012
Tan Gana NH, Onuki T, Victoriano AF, Okamoto T.
MicroRNAs in HIV-1 infection: an integration of viral and cellular interaction at the genomic level.
Front Microbiol. 3:306. 2012.
Imai K, Victoriano AF, Ochiai K, Okamoto T.
Microbial interaction of periodontopathic bacterium Porphyromonas gingivalis and HIV-possible causal link of periodontal diseases to AIDS progression-.
Curr HIV Res. 10(3):238-44. Review. 2012.
Cueno ME, Imai K, Ochiai K, Okamoto T.
Cytokinin dehydrogenase differentially regulates cytokinin and indirectly affects hydrogen peroxide accumulation in tomato leaf.
J Plant Physiol. 169(8):834-8. 2012.
Imai K, Yamada K, Tamura M, Ochiai K, Okamoto T.
Reactivation of latent HIV-1 by a wide variety of butyric acid-producing bacteria.
Cell Mol Life Sci. 69(15):2583-92. 2012.
Imai K, Yamada K, Tamura M, Ochiai K, Okamoto T.
Reactivation of latent HIV-1 by a wide variety of butyric acid-producing bacteria.
Cell Mol Life Sci. 69(15):2583-92. 2012.
2011
Tan Gana NH, Victoriano AF, Okamoto T.
Evaluation of online miRNA resources for biomedical applications.
Genes Cells. 17(1):11-27. 2011.
Victoriano AF, Okamoto T.
Transcriptional control of HIV replication by multiple modulators and their implication for a novel anti-viral therapy.
AIDS Res Hum Retroviruses. 28(2):125-38. 2011.
Okamoto T.
Positive and negative regulation of transcription from HIV provirus.
Uirusu. 61:81-89. Japanese. 2011.
Asamitsu K, Hibi Y, Imai K, Victoriano AF, Kurimoto E, Kato K, Okamoto T.
Functional characterization of human cyclin T1 N-terminal region for human immunodeficiency virus-1 Tat transcriptional activation.
J Mol Biol. 410(5):887-95. 2011
Victoriano AF, Imai K, Togami H, Ueno T, Asamitsu K, Suzuki T, Miyata N, Ochiai K, Okamoto T.
Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression.
FEBS Lett. 585(7):1103-11. 2011
2010
Gao N, Hibi Y, Cueno M, Asamitsu K, Okamoto T.
A-kinase-interacting protein 1 (AKIP1) acts as a molecular determinant of PKA in NF-kappaB signaling.
J Biol Chem. 285(36):28097-104, 2010
Tanaka K, Asamitsu K, Uranishi H, Iddamalgoda A, Ito K, Kojima H, Okamoto T.
Protecting skin photoaging by NF-kappaB inhibitor.
Curr Drug Metab. 11(5):431-5, 2010
Zineldeen DH, Uranishi H, Okamoto T.
NF-kappaB signature on the aging wall.
Curr Drug Metab. 11(3):266-75, 2010
Imai K, Togami H, Okamoto T. Involvement of histone H3 lysine 9 (H3K9) methyltransferase G9a in the maintenance of HIV-1 latency and its reactivation by BIX01294.
J Biol Chem. 285(22):16538-45, 2010
Cueno ME, Hibi Y, Imai K, Laurena AC, Okamoto T.
Impaired plant growth and development caused by human immunodeficiency virus type 1 Tat.
Transgenic Res. 9(5):903-13, 2010
Cueno ME, Hibi Y, Karamatsu K, Yasutomi Y, Imai K, Laurena AC, Okamoto T.
Preferential expression and immunogenicity of HIV-1 Tat fusion protein expressed in tomato plant.
Transgenic Res. 19(5):889-95, 2010
2009
Imai K, Asamitsu K, Victoriano AF, Cueno ME, Fujinaga K, Okamoto T.
Cyclin T1 stabilizes expression levels of HIV-1 Tat in cells.
FEBS J., 76(23):7124-33, 2009
Ohba K, Ryo A, Dewan MZ, Nishi M, Naito T, Qi X, Inagaki Y, Nagashima Y, Tanaka Y, Okamoto T, Terashima K, Yamamoto N.
Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1.
J Immunol., 183(1):524-32, 2009
Imai, K., Ochiai, K, Okamoto, T.
Reactivation of latent HIV-1 infection by the periodontopathic bacterium Porphyromonas gingivalis involves histone modification.
J Immunol., 182:3688-3695, 2009
Futoshi, T , Takahashi, N, Gao N, Akamo Y, Takeyama H, Manabe T and Okamoto T.
Phosphoinositide 3-kinase inhibitor(wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastatis in vivo.
Cancer Science, 100(4):770-7, 2009
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