研究業績
2008年以前
Fujimoto K, Chan KH, Takeda K, Lo KF, Leung RH, and Okamoto T:
Sensitive and specific enzyme-linked immunosorbent assay using chemiluminescence for detection of severe acute respiratory syndrome viral infection.
J. Clin. Microbiol., 46: 302-310, 2008
Tomoda K, Takahashi N, Hibi Y, Asamitsu K, Ishda H, Kondo T, Fujii Y, and Okamoto T:
Molecular docking analysis of the protein-protein interaction between RelA-associated inhibitor (RAI) and tumor suppressor protein p53 and its inhibitory effect on p53 action.
Cancer Science, 99: 615-622, 2008.
Gao N, Asamitsu K, Hibi Y, Ueno T, and Okamoto T:
AKIP1 enhances NF-κB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65.
J. Biol. Chem., 283: 7834-7843, 2008.
Mitsuhashi S, Kishimoto T, Uraki Y, Okamoto T, and Ubukata M:
Low molecular weight lignin suppresses activation of NF-κB and HIV-1 promoter.
Bioorg. Med. Chem., 16: 2645-2650, 2008.
Mitsuhashi S, Shima H, Li Y, Tanuma N, Okamoto T, Kikuchi K, Ubukata M.
Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation.
Int J Oncol. 33: 1027-1035, 2008
Jadlowsky KJ, Nojima M, Schulte A, Geyer M, Okamoto T, and Fujinaga K:
Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat.
Retrovirology., 5: 63, 2008.
Jadlowsky KJ, Huang Y, Nojima Geyer M, Okamoto T, and FujinagaK:
Dominant negative mutant Cyclin T1 proteins inhibit HIV transcription by forming a kinase negative complex with Tat.
J. Gen. Virol., 89: 2783-2787, 2008.
Asamitsu K, Yamaguchi T, Nakata K, Hibi Y, Victoriano AFB, Imai K, Onozaki K, Kitade Y, and Okamoto T:
Inhibition of human immunodeficiency virus type 1 replication by blocking I?B kinase with noraristeromycin.
J. Biochem., 144: 581-589, 2008.
Rimando MG, Chua MN, Yuson Ed’J, de Castro-Bernas G, and Okamoto T:
Prevalence of gstt1, gstm1 and nqo1 (609C>T) in filipino children with acute lymphoblastic leukemia (ALL).
Bioscience Rep., 28: 117-124, 2008.
Okamoto, T., Sanda, T., and Asamitsu, K. ,:
NF-kappaB signaling and carcinogenesis.
Curr. Pharm. Design, 13. 447-462. 2007.
Hamamo T., Matio K., Hibi,Y., Victoriano, A.F. Takahashi N., Mabuchi Y., Soji T., Irie S., Sawanpanyalert P., Yanai H., Hara T., Yamazaki S., Yamamoto N., and Okamoto,T
A single nucleotied synonymous mutation in gag gene controllong human immunodeficiency virus type 1 virion production.
J. Virol. 3. 1528-1533. 2007
Tanaka.K., Hasegawa.J.,Asamitu.K.,and Okamoto.T.
Mabnolia ovoata extract and its active component magnolol prevnt skin photoaging via inhibition of nuclear fator κB.
Eur. Journal of Pharmacology. 565. 212-219. 2007.
Kato H., Honma R., Sanda T., Fujiwara T., Ito E., Yanagisawa Y., Imai J., Okamoto T., and Watanabe.S.,
knock down of hSNF5/Ini1 causes cell-cycle arrest and apoptosis in a p53-dependent manner
BBRC. 361 580-585. 2007
Sanda T., Okamoto T.,Uchida Y., Nakagawa H., Iida S.,Kayukawa K.,Suzuki T., Oshizawa T., Suzuki T.,, Miyata N., and Ueda R.,
Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells
Leukemia. 21（11） 2344-2353. 2007.
Katagiri, D., Hayashi, H., Victoriano, Ann Florence B., Okamoto, T., and Onozaki, K.:
Estrogen Stimulates Transcription and Replication of Human Immunodeficiency Virus Type 1 (HIV-1).
Int. Immunopharm.6:170-181, 2006.
Okamoto, T., Sanda, T., and Asamitsu, K. ,:
NF-kappaB signaling and carcinogenesis.
Curr. Pharm. Design, 2006 (in press).
Sanda,T., Asamitsu,K., Ogura,H., Iida,S., Utsunomiya,A.,Ueda.,R., andOkamoto,T.,:
Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor.
Leukemia. 20:590-598,2006
Kanazawa S, Ota S., Sekine C., Tada T., Otsuka T., Okamoto, .,Sonderstrup G., and B. Matija Peterlin
Aberrant MHC class II expression in mouse joints leads to arthritis with extra-articular manifestaions similar to rheumatiod arthritis.
PNAS. 103. 39. 14465-14470. 2006
Victoriano, A.F.B., Asamitsu,K., Hibi, Y. ,Imai,K. , Barzaga, N.G., and Okamoto, T.:
Inhibition of HIV-1 replication in latently infected cells by a novel IkappaB kinase inhibitor.
Antimicob. Agents Chemother.50.547-555.2006
Imai,K., and Okamoto,T.,:
Transcripional Repression of Human lmmunodeficiency Virus Type 1 by AP-4 .
J. Biol.Chem.281:12495-12505.2006
Okamoto, T.
NF-kB and rheumatic diseases.
<Review> Drug Targets ? Immune, Endocrine & Metabolic Disorders. 6. 359-372. 2006
Tozawa,K., Okamoto,T., Kawai,N., Hashimoto,Y., Nagata,D., Hayashi,Y., and Kohri,K.:
Positive correlation between sialyl Lewis X expression and pathological findings in renal cell carcinoma.
Kidney Int. 67:1391-1396, 2005
Sanda, T., Iida, S., Ogura, H., Asamitsu, K., Murata, T., Bacon, K.B. Ueda R., and Okamoto, T.:
Growth inhibition of multiple myeloma cells by a novel IkB kinase inhibitor.
Clin. Can. Res. 11:1974-1982, 2005
Kobayashi, S., Kajino S., Takahashi, N., Kanazawa, S., Imai, K., Hibi, Y., Ohara, H., Itoh M. and Okamoto, T. ：
53BP2 induces apoptosis through the mitochondrial death pathway.
Genes Cells 10:253-260, 2005
Ota, S., Kanazawa, S., Kobayashi M., Otsuka T. and Okamoto, T.:
Establishment of a simple and quantitative immunospot assay for detecting anti-type II collagen antibody using infrared fluorescence imaging system (IFIS).
J. Immunol. Methods 299:189-198, 2005
Takahashi, N., Kobayashi, S., Kajino, S., Imai, K., Tomodo, K., Shimizu, S., and Okamoto, T.:
Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kB and Bcl-2 family proteins.
Genes Cells. 10:803-811 2005.
Imai, K., Nakata, K., Kawai, K., Hamano, T., Mei, N ., Kasai, H. and Okamoto, T. :
Induction of OGG 1 gene expression by HIV-1 Tat.
J. Biol.Chem. 280:26701-26713, 2005.
Tanaka, K., Hasegawa, J., Asamitsu, K. and Okamoto, T. :
Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor κB inhibitor parthenolide.
J. Pharmacol. Exp. Ther. 315:624-630, 2005
Takahashi, N., Kobayashi, S., Jiang, X., Kitagori, K., Imai, K., Hibi, Y., and Okamoto, T. ：
Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing.
Biochem. Biophys. Res. Commun. 315:434-438, 2004
Tetsuka, T., Uranishi, H., Sanda, T., Asamitsu, K., Yang, J-P., Wong-Staal, F. and Okamoto, T. :
RNA helicase A interacts with nuclear factor-[[kappa]]B p65 and functions as a transcriptional coactivator.
Eur. J. Biochem. 271: 3741-3751, 2004
Jiang, X., Takahashi, N., Matsui, N., Tetsuka, T., and Okamoto, T.:
The NF-kB activation in the lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536.
J. Biol. Chem. 278: 919-926, 2003
Jiang, X., Takahashi, N., Ando, K., Otsuka, T., Tetsuka, T., and Okamoto, T.:
NF-kB p65 transacvation domain is involved in the NF-kB-inducing kinase (NIK) pathway.
Biochem. Biophys. Res. Commun. 301:583-590, 2003
Ohata, H., Tetsuka, T., Hayashi, H., Onozaki, K., and Okamoto, T.:
3-Methylcholanthrene activates human immunodeficiency virus type 1 replication via aryl hydrocarbon receptor.
Microbiol. Immunol. 2003 (in press)
Teranishi, F., Liu, Z-.Q., Kunimatsu, M., Imai, K., Takeyama, H., Manabe, T., Sasaki, M., and Okamoto, T.:
Calpain is involved in the HIV replication from the latently-infected OM10.1 cells.
Biochem. Biophys. Res. Commun. 2003 (in press)
Matsumura, T., Degawa, T., Takii, T., Hayashi, H., Okamoto, T., Inoue, J., and Onozaki, K.:
TRAF6-NF-kB pathway is essential for IL-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes.
Immunology 2003 (in press)
Okano, A., Usuda, N., Furihata, K., Nakayama, K., Tian, Q B., Okamoto, T., and Suzuki, T.：
Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions.
Brain Res. 2003 (in press)
Asamitsu, K., Kanazawa, S., Tetsuka, T., and Okamoto T.：
RING finger protein AO7 supports the NF-kB-mediated transcription by interacting with the transactivation domain of p65 subunit.
J. Biol. Chem. 2003 (in press)
Kanazawa, S., Soucek, L., Evan, G., Okamoto, T., and Peterlin, B. M.:
c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis.
Oncogene 2003 (in press)
Matsumoto, S., Imaeda, Y., Umemoto, S., Kobayashi, K., and Okamoto, T.:
Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumor cells. Br.
J. Cancer, 86:161-167, 2002.
Kawabe,T., Suganuma, M., Ando, T., Kimura, M., Hori, H., and Okamoto, T.:
Cdc25C interacts with PCNA at G2/M transition.
Oncogene 21: 1717-1726, 2002.
Maki, M., Matsukawa, N., Yuasa, H., Otsuka, Y., Yamamoto, T., Akatsu, H., Okamoto, T., Ueda, R., and Ojika, K.:
Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer's disease.
J. Neuropathol. Exp. Neurol. 61: 176-185, 2002.
Sarol, L.C., Imai, K., Asamitsu, K., Tetsuka, T., Barzaga, N.G., and Okamoto, T.:
Inhibitory effects of IFN-g on HIV-1 replication in latently infected cells.
Biochem. Biophys. Res. Commun. 291: 890-896, 2002.
Tozawa, K., Okamoto, T., Hayashi, Y., Sasaki, S., Kawai, N., and Kohri, K.:
N-acetyl-L-cysteine enhances chemotherapeutic effect on prostate cancer cells.
Urol Res. 30:53-58, 2002.
Takada, N., Sanda, T., Okamoto, H., Yang, J.-P., Asamitsu, K., Sarol, L., Kimura, G., Uranishi, H., Tetsuka, T., and Okamoto,T.:
RelA-associated inhibitor blocks transcription of human immunodeficiency virus type1 by inhibiting NF-kB and Sp1 actions.
J. Virol. 76: 8019-8030, 2002.
Watanabe, N., Ando, K., Yoshida, S., Inuzuka, S., Kobayashi, M., Matsui, N., and Okamoto, T.:
Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium.
Biochem. Biophys. Res. Commun. 294: 1121-1129, 2002.
Takahashi, N., Tetsuka, T., Uranishi, H., and Okamoto, T.:
Inhibition of NF-kB transcriptional activity by protein kinase A.
Eur. J. Biochem. 269:1-7, 2002.
Matsumoto, S., Imaeda, Y., Umemoto, S., Kobayashi, K., and Okamoto, T.:
Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumor cells.
Br. J. Cancer, 86:161-167, 2002.
Uranishi, H., Tetsuka, T., Yamashita, M., Asamitsu, K., Shimizu, M., Itoh, M., and Okamoto, T. :
Involvement of the pro-oncoprotein TLS (Translocated in liposarcoma) in nuclear factor-kB p65-mediated transcription as a coactivator.
J. Biol. Chem. 276: 13395-13401, 2001.
Senoo, M., Tsuchiya, I., Matsumura, Y., Mori, T., Saito,Y., Kato, H., Okamoto, T., and Habu, S.:
Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of ΔNp73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51.
Br. J. Cancer 84: 1235-1241, 2001.
Ando, T., Kawabe, T., Ohara, H., Ducommun, B., Itoh, M., and Okamoto, T.:
Involvement of interaction between p21 and PCNA for the maintenance of G2/M arrest after DNA damage.
J. Biol. Chem. 276:42971-42977, 2001.
Suzuki, M., Tetsuka, T., Yoshida,S., Watanabe, N., Kobayashi, M., Matsui, N., and Okamoto, T.:
The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-α or IL-1β stimulated rheumatoid synovial fibroblasts.
FEBS Lett. 465:23-27, 2000.
Mori, T., Okamoto,H., Takahashi,N., Ueda, R., and Okamoto, T.:
Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines.
FEBS Lett. 465:124-128, 2000.
Tetsuka, T., Uranishi,H., Imai, H., Ono,T., Sonta, S., Takahashi, N., Asamitsu, K., and Okamoto, T.:
Inhibition of nuclear factor-kB-mediated transcription by association with the amino-terminal enhancer of split (AES), a Groucho-related protein lacking WD40 repeats.
J. Biol. Chem. 275:4383-4390, 2000.
Kameoka, M., Ota, K., Tetsuka, T., Tanaka, Y., Itaya,A., Okamoto, T., and Yoshihara,K. :
Evidence for regulation of NF-κB by poly (ADP-ribose) polymerase.
Biochem. J. 346:641-649, 2000.
Kajino, S., Suganuma, M., Teranishi, F., Takahashi, N., Tetsuka, T., Ohara, H., Ito, M., and Okamoto, T.:
Evidence that de novo protein synthesis is dispensable for anti-apoptotic effects of NF-κB.
Oncogene 19:2233-2239, 2000.
Kanazawa, S., Okamoto,T., and Peterlin, B. M. :
Tat competes with CIITA for the binding to P-TEFb and blocks the exprression of MHC class II genes in HIV infection.
Immunity 12:61-70, 2000.
Okamoto, H., Cujec, T.P., Peterlin, B. M., and Okamoto,T.:
HIV-1 replication is inhibited by a pseudo-substrate peptide that blocks Tat transactivation.
Virology 270:337-344, 2000.
Kobayashi, K., Matsumoto, S., Morishima, T., Kawabe, T., and Okamoto, T.:
Prevention of cancer metastasis by cimetidine through blocking the expression of E-selectin on endothelial cells.
Cancer Res. 60:3978-3984, 2000.
Okamoto, H., Cujec, T.P., Okamoto, M., Peterlin, B.M., Baba, M., and Okamoto, T.:
Inhibition of the RNA-dependent tansactivation and replication of human immunodeficiency virus type 1 by a fluoroquinoline derivative K-37.
Virology 272:402-408, 2000.
Nagaya, T., Fujieda, M., Otsuka, G., Yang, J-P., Okamoto, T., and Seo, H.:
A potential role of activated NF-kB in the pathogenesis of euthyroid sick syndrome.
J. Clin Invest. 106:393-402, 2000.
Okamoto, H., Asamitsu, K., Nishimura, H., Kamatani, N., and Okamoto, T.:
Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
Biochem. Biophys. Res. Commun. 279:494-499, 2000.
Nagao, N., Etoh, T., Yamaoka, S., Okamoto, T., and Miwa N.:
Enhanced invasion of tax-expressing fibroblasts into the basement membrane is repressed by phosphorylated ascorbate with simultaneous decreases in intracellular oxidative stress and NF-kB activation.
Antioxid. Redox Signal. 2:727-738, 2000.
Saliou, C., Kitazawa, M., Mclaughlin, L., Yang. J.-P., Lodge, J.K., Iwasaki, K., Cillard, J., Okamoto, T., and Packer, L.:
Antioxidants modulate acute solar ultraviolet radiation-induced NF-kB activation in a human keratinocyte cell line.
Free Radic. Biol. Med. 26:174-183, 1999.
Asamitsu, K., Sakurada, S., Mashiba, K., Nakagawa, K., Torikai, K., Onozaki, K., and Okamoto, T.:
Alteration of the cellular response to interleuklin-1βby SV40 large T antigen in rheumatoid synovial fibroblasts.
Arch. Virol. 144:317-327, 1999.
Traber, E.K., Okamoto, H., Kurono, C., Baba, M., Saliou, C., Soji, T., Packer, L., and Okamoto, T.:
Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-α-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells.
Int. Immunol. 11:143-150, 1999.
Yoshida, S., Kato, T., Sakurada, S., Kurono, C., Yang, J.-P., Matsui, N., Soji, T., and Okamoto, T.:
Inhibition of IL-6 and IL-8 induction from the cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose.
Int. Immunol. 11:151-158, 1999.
Okamoto, M., Okamoto, T., and Baba, M.:
Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells.
Antimicrob. Agents. Chemother. 43:492-497, 1999.
Yang, J.-P., Hori, M., Sanda, T., and Okamoto, T.:
Identification of a novel inhibitor of nuclear factor-kB, RelA-associated inhibitor.
J. Biol. Chem. 274:15662-15670, 1999.
Yang, J.-P., Hori, M.,Takahashi,N., Kawaba, T., Kato, H., and Okamoto, T.:
NF-κB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2.
Oncogene 18:5177-5186, 1999.
Takahashi, N., Takada, N., Hashimoto, T., and Okamoto, T.:
Genetic heterogeneity of the immunogenic viral capsid protein region of human parvovirus B19 isolates obtained from a single outbreak in a paediatric ward.
FEBS Lett. 450:289-293, 1999.
Goto, D., Izumi, H., Ono, M., Okamoto, T., Kohno, K., and Kuwano, M.:
Tubular morphogenesis by genotoxic therapeutic agents that induce NF-kB activation in human vascular endothelial cells.
Angiogenesis 2:345-356, 1999.
Yoshida, S., Katoh, T., Tetsuka, T., Uno K., Matsui, N., and Okamoto, T.:
Involvement of thioredoxin in rheumatoid arthritis: Its co-stimulatory roles in the TNFa-induced production of IL-6 and IL-8 from the cultured synovial fibroblasts.
J. Immunol. 163: 351-358, 1999.
Maurice , M. M. , Nakamura, H. , Okamoto, T., Yoshida, S., Kullmann, F., Lechner, S., van der Voort, E. A. M., Leow, A., Versendaal, J., Muller-Landner, U., Yodoi, J ., Tak, P. P., Breedveld, F. C., and Verweij, C. L.:
Expression of the thioredoxin-thioredox reductase system in the inflamed joints of patients with rheumatoid arthritis.
Arthritis Rheum. 42:2430-2439, 1999.
Asamitsu, K., Morishima, T., Tsuchie, H., Kurimura, T., and Okamoto, T.:
Conservation of the central proline-rich (PxxP) motifs of human immunodeficiency virus type 1 Nef protein during the disease progression in two hemophiliac patients.
FEBS Lett. 459: 399-404, 1999.
Suganuma, M., Kawabe, T., Hori, H., Funabiki, T., and Okamoto, T.:
Sensitization of cancer cell to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation.
Cancer Res. 59:5887-5891, 1999.
Sakaguchi, T., Nakamura, S., Suzuki, S., Oda, T., Ichiyama, A., Baba, S., and Okamoto, T.:
Participation of platelet-activating factor in the lipopolysaccharide-induced liver injury in partially hepatectomized rats.
Hepatology 30:959-967, 1999.
