名古屋市立大学大学院医学研究科 生体情報・機能制御医学専攻・病態医科学講座　 山崎研究室

Publications(selected)

2022
・ Minohara K,  Imai M, Matoba T, Wing JB, Shime H, Odanaka M, Uraki R, Kawakita D, Toyama T,Takahashi S, Morita A, Murakami S, Ohkura N, Sakaguchi S, Iwasaki S, Yamazaki S*. Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer. Cancer Sci.　2022 Dec 18. doi: 10.1111/cas.15698.
*Corresponding author

2021
・ Uraki R, Imai M, Ito M, Shime H, Odanaka M, Okuda M, Kawaoka Y, Yamazaki S*. Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens． PLoS Pathog.　2021 Dec 9;17(12):e1010085.　*Corresponding author

2020
・ Shime H, Odanaka M, Tsuiji M, Matoba T, Imai M, Yasumizu Y, Uraki R, Minohara K, Watanabe M, Bonito AJ, Fukuyama H, Ohkura N, Sakaguchi S, Morita A, Yamazaki S*. Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function． Proc Natl Acad Sci USA.  2020 Aug 7;202000372.　*Corresponding author

2019
・ Ikumi K, Odanaka M, Shime H, Imai M, Osaga S, Taguchi O, Nishida E, Hemmi H, Kaisho T, Morita A, Yamazaki S*. Hyperglycemiais associated with psoriatic inflammation in both humans and mice. J Invest Dermatol. 2019 Jun;139(6):1329-1338.e7.　*Corresponding author

・ Matoba T, Imai M, Ohkura N, Kawakita D,Ijichi K, Toyama T, Morita A, Murakami S, Sakaguchi S, Yamazaki S*. Regulatory T cells expressing abundant CTLA-4 on the cell surface with a proliferative gene profile are key featuresof human head and neck cancer.  Int J Cancer.  2019   Jun 1;144(11): 2811-2822.　*Corresponding author

2018
・ Loh JT, Lim TJF, Ikumi K, Matoba T, Janela B, Gunawan M, Toyama T, Bunjamin M, NgLG, Poidinger M, Morita A, Ginhoux F, Yamazaki S, Lam KP, Su IH. Ezh2 Controls Skin Tolerance through Distinct Mechanisms in Different Subsets of Skin Dendritic Cells. iScience. 2018 Nov14;10: 23-39.

・ Yamazaki S*, Odanaka M, Nishioka A, Kasuya S, Shime H, Hemmi H, Imai M, Riethmacher D, Kaisho T, Ohkura N, Sakaguchi S, Morita A. Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin.J  Immunol. 2018 Jan 1; 200 (1):119-129.　*Corresponding author

2017
・ Kubo R, Muramatsu S, Sagawa Y, Saito C, Kasuya S, Nishioka A, Nishida E, Yamazaki S, Morita A.  Bath-PUVA therapy improves impaired resting regulatory T cells and increases activated regulatory T cells in psoriasis. J Dermatol Sci. 2017 Apr;86(1):46-53

2015
・ Gunawan M, Venkatesan N, Loh JT, Wong JF, Berger H, Neo WH, Li LY, La Win MK, Yau YH, Guo T, See PC, Yamazaki S, Chin KC, Gingras AR, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH.  The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nat Immunol. 2015 May;16(5):505-16.

2014
・ Yamazaki S*, Nishioka A, KasuyaS, Ohkura N, Hemmi H, Kaisho T, Taguchi O, Sakaguchi S, Morita A. Homeostasisof thymus-derived Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin.J Immunol. 2014 Dec 1;193(11):5488-97.　*Corresponding author

・ Ito Y, Hashimoto M, Hirota K,Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N,Sakaguchi S. Detection of T cell responses to a ubiquitous cellular protein inautoimmune disease. Science. 2014 Oct 17;346(6207):363-8.

～2013 (selected)
・ Yamazaki S*, Morita A. Dendritic cells in the periphery controlantigen-specific Natural and Induced regulatory T cells.Frontier Immunol  2013;4: Article151, 1-13. *Corresponding  author.

・ Yamazaki S*, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T Dendritic cells from oral cavity induce Foxp3+ regulatory T cells upon antigen stimulation.PLoS One  2012; 7: e51665 *Corresponding author.

・ Yamazaki S*, Okada K, Maruyama A, Matsumoto M, Yagita H, Seya T. TLR2-dependent induction of IL-10 and Foxp3+CD25+CD4+ regulatory T cells prevents effective anti- tumor immunity induced by Pam2 lipopeptides in vivo.PLoS One  2011;6:e18833. *Corresponding  author

・ Yamazaki S*, Steinman RM. Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells.J Dermatol Sci 54,69-75,2009. *Corresponding author

・ Yamazaki S*, Dudziak D, Heidkamp GF, Fiorese C, Bonito AJ, Inaba K, Nussenzweig MC, Steinman RM. CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells.J Immunol 181: 6923-6933, 2008. *Corresponding author

・ Yamazaki S*, Bonito AJ, Spisek R, Dhodapkar M, Inaba K, Steinman RM.  Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+CD4+ regulatory T cells from peripheral Foxp3- precursors. Blood 110:4293-4302,2007. *Corresponding author

・ Dudziak D, Kamphorst AO, Heidkamp GF, Buchholz VR, Trumpfheller C, Yamazaki S, Cheong C, Liu K, Lee HW, Park CG, Steinman RM, Nussenzweig MC. Differential antigen processing by dendritic cell subsets in vivo. Science 315:107-11,2007.

・ Yamazaki S, Patel M, Harper A, Bonito A, Fukuyama H, Pack M, Tarbell KV, Talmor M, Ravetch JV, Inaba, K, Steinman RM.  Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction. Proc Natl Acad Sci  USA 103: 2758-2763, 2006.

・ Yamazaki S*, Inaba K, Tarbell KV, Steinman RM.  Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+ regulatory T cells including suppressors of alloreactivity. Immunol Rev 212:314-329, 2006. * Corresponding author

・ Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, Shimizu J, Nomura T, Chiba T, Sakaguchi S. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med  202:885-891, 2005.

・ Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM.  CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp  Med  199:1467-1477,2004.

・ Yagi H, Nomura T, Nakamura K, Yamazaki S, Kitawaki T, Hori S, Maeda M, Onodera M, Uchiyama T, Fujii S, Sakaguchi S. Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells.  Int Immunol  16:1643-56, 2004.

・ Yamazaki S,  Iyoda T, Tarbell K, Olson K, Velinzon K, Inaba K, Steinman RM. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen processing dendritic cells. J Exp Med  198:235-247, 2003.

・ Sakaguchi N,  Takahashi T,  Hata H, Nomura T, Tagami T, Yamazaki S,Sakihama T,  Matsutani T,  Negishi I, Nakatsuru S,  Sakaguchi S.  Altered thymicT-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice.　Nature  426:454-460, 2003.

・ Kang Y-S*, Yamazaki S* (*Equallycontribution),  IyodaT*,  Pack M,  Bruening SA,  Kim MY,  Takahara K,  Inaba K,  Steinman RM#,  Park C-G# (# Equally contribution).   SIGN-R1, a novel C-type lectin expressed bymarginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran. Int Immunol.  15:177-86, 2003. Outstanding Merit Award 2003受賞論文

・ Shimizu, J*, Yamazaki S*, Takahashi T, Ishida Y, Sakaguchi S. Stimulation of CD25+CD4+  regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol  3:135-142, 2002. *Equally contributed first author


・ Shimizu J, Yamazaki S, Sakaguchi S. Induction of tumor immunity by removing CD25+CD4+ T cells: A common basis between tumor immunity and autoimmunity. J Immunol  163:5211 5218, 1999.