2018年

 

Ogawa, Takuya; Okihara, Hidemasa; Kokai, Satoshi; Abe, Yasunori; Karin Harumi, UchimaKoecklin; Makiguchi, Mio; Kato, Chiho; Yabushita, Tadachika; Michikawa, Makoto, Ono, Takashi.

Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone level.

J Neurosci Res, in press. 2018

 


2017年

 

ZuiZhanga, Yoshiko Takeda-Uchimuraa, TahminaFoyeza, ShioriOhtake-Niimia, Narentuyaa, Hiroyasu Akatsu,KazuchikaNishitsuji, Makoto Michikawa, Tony Wyss-Coray, Kenji Kadomatsu, and Kenji Uchimura.

Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer’s pathology.

Proc Natl AcadSci USA, 2017

 

Naoyuki Ishida, Yuichi Ishihara, Kazuto Ishida, Hiroyuki Tada, Yoshiko Funaki-Kato, Makoto Hagiwara, Taslima Ferdous, Mohammad Abdullah, Akio Mitani, Makoto Michikawa, Kenji Matsushita

Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice.

Aging Mech Dis, in press

 


2016年

 

Yosuke Takeda, Hiroshi Oue, Shinsuke Okada, Akira Kawano, Katsunori Koretake, Makoto Michikawa, Yasumasa Akagawa, Kazuhiro Tsuga

Molar loss and powder diet leads to memory deficit and modifies the mRNA expression of brain-derived neurotrophic factor in the hippocampus of adult mice.

BMC Neurosci, 17: 81, 2016

 

Nunome M, Enomoto H, Abdullah M, Gong JS, Jung CG, Kamijima M, Michikawa M.

Effects of overexpression of lipoprotein lipase (LPL) on Aβ burden and memory function in LPL and APP-double-transgenic mice.

J System Integr Neurosci, in press.

 

Ko M, Hattori T, Abdullah M, Gong JS, Yamane T, Michikawa M.

Phosphatidylcholine protects neurons from toxic effects of amyloid beta-protein in culture.

Brain Res, 1642: 376-383, 2016.

 

Sano O, Tsujita M, Shimizu Y, Kato R, Kobayashi A, Kioka N, Remaley AT, Michikawa M, Ueda K, and Matsuo M.

ABCG1 and ABCG4 suppress g-secretase activity and amyloid β production.

PLOS ONE, 11(5): e0155400, 2016.

 

Abdullah M, Takase H, Nunome M, Enomoto H, Ito J-I, Gong J-S, and Michikawa M.

Aβ reduces exosome release from astrocytes by enhancing JNK phosphorylation.

J Alzhiemer Dis, 53: 1433-1441, 2016.

 

Gong J-S, Abdullah M, Nunome M, Enomoto H, Ito J, and Michikawa M.

Memantine prevents Aβ-induced neuronal death in vitro.

Glob Vaccines Immunol, 1(1): 14-18, 2016

 

Oue, H, Miyamoto, Y, Koretake, K, Okada, S, Doi, K, Jung, C.-G, Michikawa, M. Akagawa, Y.

Tooth loss might not alter molecular pathogenesis in an aged transgenic Alzheimer's disease model mouse.

Gerodontology 33(3): 308-14, 2016.

 

Fuwa, D, Fukuda, M, Ogiyama, Y, Sato, R, Mizuno, M, Miura, T, Abe-Dohmae,Michikawa, M, Kobori, H, Ohte, N.

Addition of hydrochlorothiazide to angiotensin receptor blocker therapy can achieve a lower sodium balance with no acceleration of intrarenal renin angiotensin system in patients with chronic kidney disease.

J Renin Angiotensin Aldosterone Syst, 2016, 2016 Jun 9;17(2)

 


2015年

 

Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, Tanabe C, Maeda T, Michikawa M, Komano H.

Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology.

Sci Rep. 2015 Jul 8;5:12059.

 

Hosono T, Mouri A, Nishitsuji K, Jung C-G, Kontani M, Tokuda H, Kawashima H, Shibata H, Suzuki T, Nabeshima T, Michikawa M.

Arachidonic or docosahezanenoic acid diet prevents memory impairment in Tg2576 mice.

J Alzheimers Dis.,48(1): 149-162, 2015

 

Hosono T, Nishitsuji K, Nakamura T, Jung C-G, Kontani M, Tokuda H, Kawashima H, Kiso Y, Suzuki T, Michikawa M.

Arachidonic Acid Diet Attenuates Aβ Deposition in Tg2576 Mice.

Brain Res, 1613: 92-99, 2015.

 

Ito J, Nagayasu Y, Ogawa T, Okihara H, Michikawa M.

Biochemical properties in membrane of rat astrocytes under oxidative stress.

Brain Res, 1615: 1-11, 2015.

 

Md.Sheikh, Michikawa M, Kim S-U, Nagai A.

Lysophosphatidylcholine increases the neurotoxicity of Alzheimer’s amyloid β1-42 peptide: Role of oligomer formation.

Neuroscience, 292: 159-69, 2015.

 

Ohm K-O, Kim M-J, Kawqaguchi M, Akatsu H, Miura Y, Misumi S, Hida H, Choi E-K, Kim Y-S, Michikawa M, Jung C-G.

ATBF1 is a novel amyloid precursor binding protein that affects amyloid β production.

J Alzheimers Dis, 43: 243-57, 2015.

 

Jung C-G., Ohm K-O, Horike H, Kim M-J, Misumi S, Ishida A, Ueda Y, Choi E-K, Kim Y-S, Michikawa M, Hida H.

Auraptene increases the production of amyloid-beta via c-Jun N-terminal kinase -dependent activation of γ-secretase.

J Alzheimers Dis, 43: 1215-28, 2015.

 


2014年

 

Okihara H, Ito J, Kokai S, Ishida T, Hiranuma M, Kato C, Yabushita T, Ishida K, Ono T, Michikawa M.

Liquid diet induces memory impairment accompanied by a decreased number of hippocampal neurons in mice.

J Neurosci Res. 92(8):1010-7 2014

 

Ito JI, Nagayasu Y, Miura Y, Yokoyama S, Michikawa M.

Astrocytes endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1.

Brain Res. 27;1570:1-12. 2014

 

Nagayasu Y, Morita S, Hayashi H, Miura Y, Yokoyama K, Michikawa M, Ito J.

Incresing cellular level of phosphatidic acid enhances FGF-1 production in long-term cultured rat astrocytes.

Brain Res, 1563:31-40, 2014.

 

Kheirollah A, Nagayasu Y, Ueda H, Yokoyama S, Michikawa M, Ito J.

Involvement of cdc42/Rho kinase in apoA-I-mediated cholesterol efflux through interaction between cytosolic lipid-protein particles and microtubules in rat astrocytes.

J Neurosci Res, 92(4):455-463, 2014.

 

Hoshino H, Foyez T, Ohtake-Niimi S, Takeda-Uchimura Y, Michikawa M, Kadomatsu K and Uchimura K

KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain

J Histochem Cytochem, 62(2), 145-56, 2014.

 

 


2013年

 

Oue H, Miyamoto Y, Okada S, Koretake K, Jung CG, Michikawa, M, Akagawa, Y.

Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice.

Behav Brain Res 252: 318-325, 2013

 

Zou K, Liu J, Watanabe A, Hiraga S, Liu S, Tanabe C, Maeda T, Terayama Y, Takahashi S, Michikawa M, Komano H.

Aβ43 is the earliest depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE

Am J Pathol, 182: 2322-2331, 2013

 

Ito J, Nagayasu Y, Hoshikawa M, Kato K.H., Miura Y, Asai K, Hayashi H, Yokoyama Y, Michikawa M.

Enhancement of FGF-1 release along with cytosolic proteins from rat astrocytes by hydrogen peroxide

Brain Res., 1552: 12-21, 2013

 

Ito J, Gong J, Michikawa M. 

Oxidative Stress and FGF-1 release from Astrocytes.

J Alzheimer's Dis Parkinsonism, 2013, 3.5

 

 


2012年

 

Hosono-Fukao T, Ohtake-Niimi S, Hoshino H, Akatsu H, Hossain M, Nishitsuji K, van Kuppevelt, Kimata K, Michikawa M, Wyss-Coray T, Uchimura K.

Heparan sulfate subdomains that are degraded by sulf accumulate in cerebral amyloid β plaques of Alzheimer's disease : Evidence from mouse models and patients.

Am J Pathol, 180(5): 2056-2067, 2012.

 

Yasuno F, Tanimukai S, Sasaki M, Hidaka S, Ikejima C, Yamashita F, Kodama C, Mizukami K, Michikawa M, Asada T.

Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype.

Am. J. Geriat. Psychiat. 20(7): 574-583, 2012

 

 


2011年

 

Nishitsuji K, Hosono T, Uchimura K, Michikawa M.

Lipoprotein lipase is a novel A beta -binding protein that promotes glycosaminoglycan- dependent cellular uptake of A in astrocytes.

J. Biol. Chem. 286: 6393-6401, 2011.

 

Nishitsuji K, Hosono T, Nakamura T, Bu G, Michikawa M.

Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain-barrier

model.

J. Biol. Chem. 286(20): 17536-17542, 2011.

 

Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M,

Michikawa M, Matsubara E.

The dissociation of Aβ from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates Aβ42 assembly.

J. Neurosci. Res. 6: 815-821, 2011

 

Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Shoji M, Yanagisawa K,

Michikawa M, Matsubara E.

Extracellular and intraneuronal HMW-A oligomers represent a molecular basis of memory loss in Alzheimer's disease model mouse.

Mol. Neurodegener. 2011; 6: 20.

 

Akatsu H, Ogawa N, Kanesaka T, Hori A, Yamamoto T, Matsukawa N, Michikawa M.

Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease.

J. Neurol. Sci. 2011; 300: 67-73.

 

Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H.

ER-stress-inducible Herp, facilitates the degradation f immature nicastrin.

Biochim. Biophys. Acta. 1810: 790-8, 2011.

 

Hosono-Fukao T, Ohtake-Niimi S, Nishitsuji K, Hossain M, van Kuppevelt TH, Michikawa M, Uchimura K.

RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature.

J. Neurosci. Res., 89: 1840-8 ,2011.

 

Jung C-G, Uhm K-O, Miura Y, Hosono T, Horike H, Khanna K K, Michikawa M.

Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons.

Mol Neurodegener, 6: 47, 2011.

 

 


2010年

 

Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung C-G, Komano H,

Michikawa M.

Homocysteine, another risk factor for Alzheimer's disease, impairs apolipoprotein E3 function.

J. Biol. Chem. 2010; 285:38382-38388.

 

Jung C-G, Horike H, Cha B-Y, Uhm K-O, Yamauchi R, Yamaguchi T, Hosono T, Iida K, Woo J-T, Michikawa M.

Honokiol increases ABCA1 expression level by activating retinoid X receptor β.

Biol. Pharm. Bull, 2010; 33:1105-1111.