2015年

 

Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, Tanabe C, Maeda T, Michikawa M, Komano H.

Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology.

Sci Rep, in press.

 

Hosono T, Mouri A, Nishitsuji K, Jung C-G, Kontani M, Tokuda H, Kawashima H, Shibata H, Suzuki T, Nabeshima T, Michikawa M.

Arachidonic or docosahezanenoic acid diet prevents memory impairment in Tg2576 mice.

J Alzheimer Dis, in press, 2015.

 

Hosono T, Nishitsuji K, Nakamura T, Jung C-G, Kontani M, Tokuda H, Kawashima H, Kiso Y, Suzuki T, Michikawa M.

Arachidonic Acid Diet Attenuates Aβ Deposition in Tg2576 Mice.

Brain Res, 1613: 92-99, 2015.

 

Ito J, Nagayasu Y, Ogawa T, Okihara H, Michikawa M.

Biochemical properties in membrane of rat astrocytes under oxidative stress.

Brain Res, 1615: 1-11, 2015.

 

Md.Sheikh, Michikawa M, Kim S-U, Nagai A.

Lysophosphatidylcholine increases the neurotoxicity of Alzheimer’s amyloid β1-42 peptide: Role of oligomer formation.

Neuroscience, 292: 159-69, 2015.

 

Ohm K-O, Kim M-J, Kawqaguchi M, Akatsu H, Miura Y, Misumi S, Hida H, Choi E-K, Kim Y-S, Michikawa M, Jung C-G.

ATBF1 is a novel amyloid precursor binding protein that affects amyloid β production.

J Alzheimers Dis, 43: 243-57, 2015.

 

Jung C-G., Ohm K-O, Horike H, Kim M-J, Misumi S, Ishida A, Ueda Y, Choi E-K, Kim Y-S, Michikawa M, Hida H.

Auraptene increases the production of amyloid-beta via c-Jun N-terminal kinase -dependent activation of γ-secretase.

J Alzheimers Dis, 43: 1215-28, 2015.

 

2014年

 

Okihara H, Ito J, Kokai S, Ishida T, Hiranuma M, Kato C, Yabushita T, Ishida K, Ono T, Michikawa M.

Liquid diet induces memory impairment accompanied by a decreased number of hippocampal neurons in mice.

J Neurosci Res. 92(8):1010-7 2014

 

Jung C-G., Ohm K-O, Horike H, Kim M-J, Misumi S, Ishida A, Ueda Y, Choi E-K, Kim Y-S, Michikawa M, Hida H.

Auraptene increases the production of amyloid-beta via c-Jun N-terminal kinase -dependent activation of γ-secretase.

J Alzheimers Dis, in press.

 

Ohm K-O, Kim M-J, Kawqaguchi M, Akatsu H, Miura Y, Misumi S, Hida H, Choi E-K, Kim Y-S, Michikawa M, Jung C-G.

ATBF1 is a novel amyloid precursor binding protein that affects amyloid b production.

J Alzheimers Dis, in press.

 

Ito JI, Nagayasu Y, Miura Y, Yokoyama S, Michikawa M.

Astrocytes endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1.

Brain Res. 27;1570:1-12. 2014

 

Nagayasu Y, Morita S, Hayashi H, Miura Y, Yokoyama K, Michikawa M, Ito J.

Incresing cellular level of phosphatidic acid enhances FGF-1 production in long-term cultured rat astrocytes.

Brain Res, 1563:31-40, 2014.

 

Kheirollah A, Nagayasu Y, Ueda H, Yokoyama S, Michikawa M, Ito J.

Involvement of cdc42/Rho kinase in apoA-I-mediated cholesterol efflux through interaction between cytosolic lipid-protein particles and microtubules in rat astrocytes.

J Neurosci Res, 92(4):455-463, 2014.

 

Hoshino H, Foyez T, Ohtake-Niimi S, Takeda-Uchimura Y, Michikawa M, Kadomatsu K and Uchimura K

KSGal6ST is essential for the 6-sulfation of galactose within keratan sulfate in early postnatal brain

J Histochem Cytochem, 62(2), 145-56, 2014.

 

 

2013年

 

Oue H, Miyamoto Y, Okada S, Koretake K, Jung CG, Michikawa, M, Akagawa, Y.

Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice.

Behav Brain Res 252: 318-325, 2013

 

Zou K, Liu J, Watanabe A, Hiraga S, Liu S, Tanabe C, Maeda T, Terayama Y, Takahashi S, Michikawa M, Komano H.

Aβ43 is the earliest depositing Aβ species in APP transgenic mouse brain and is converted to Aβ41 by two active domains of ACE

Am J Pathol, 182: 2322-2331, 2013

 

Ito J, Nagayasu Y, Hoshikawa M, Kato K.H., Miura Y, Asai K, Hayashi H, Yokoyama Y, Michikawa M.

Enhancement of FGF-1 release along with cytosolic proteins from rat astrocytes by hydrogen peroxide

Brain Res., 1552: 12-21, 2013

 

Ito J, Gong J, Michikawa M. 

Oxidative Stress and FGF-1 release from Astrocytes.

J Alzheimer's Dis Parkinsonism, 2013, 3.5

 

 

2012年

 

Hosono-Fukao T, Ohtake-Niimi S, Hoshino H, Akatsu H, Hossain M, Nishitsuji K, van Kuppevelt, Kimata K, Michikawa M, Wyss-Coray T, Uchimura K.

Heparan sulfate subdomains that are degraded by sulf accumulate in cerebral amyloid β plaques of Alzheimer's disease : Evidence from mouse models and patients.

Am J Pathol, 180(5): 2056-2067, 2012.

 

Yasuno F, Tanimukai S, Sasaki M, Hidaka S, Ikejima C, Yamashita F, Kodama C, Mizukami K, Michikawa M, Asada T.

Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype.

Am. J. Geriat. Psychiat. 20(7): 574-583, 2012

 

 

2011年

 

Nishitsuji K, Hosono T, Uchimura K, Michikawa M.

Lipoprotein lipase is a novel A beta -binding protein that promotes glycosaminoglycan- dependent cellular uptake of A in astrocytes.

J. Biol. Chem. 286: 6393-6401, 2011.

 

Nishitsuji K, Hosono T, Nakamura T, Bu G, Michikawa M.

Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain-barrier

model.

J. Biol. Chem. 286(20): 17536-17542, 2011.

 

Yasuno F, Tanimukai S, Sasaki M, Hidaka S, Ikejima C, Yamashita F, Kodama C, Mizukami K, Michikawa M, Asada T.

Association between cognitive function and plasma lipids of the elderly after controlling for apolipoprotein E genotype.

Am J Geriatr Psychiatry. 20(7):574-83. 2012

 

Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M,

Michikawa M, Matsubara E.

The dissociation of Aβ from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates Aβ42 assembly.

J. Neurosci. Res. 6: 815-821, 2011

 

Takamura A, Okamoto Y, Kawarabayashi T, Yokoseki T, Shibata M, Mouri A, Nabeshima T, Sun H, Abe K, Shoji M, Yanagisawa K,

Michikawa M, Matsubara E.

Extracellular and intraneuronal HMW-A oligomers represent a molecular basis of memory loss in Alzheimer's disease model mouse.

Mol. Neurodegener. 2011; 6: 20.

 

Akatsu H, Ogawa N, Kanesaka T, Hori A, Yamamoto T, Matsukawa N, Michikawa M.

Higher activity of peripheral blood angiotensin-converting enzyme is associated with later-onset of Alzheimer's disease.

J. Neurol. Sci. 2011; 300: 67-73.

 

Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H.

ER-stress-inducible Herp, facilitates the degradation f immature nicastrin.

Biochim. Biophys. Acta. 1810: 790-8, 2011.

 

Hosono-Fukao T, Ohtake-Niimi S, Nishitsuji K, Hossain M, van Kuppevelt TH, Michikawa M, Uchimura K.

RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature.

J. Neurosci. Res., 89: 1840-8 ,2011.

 

Jung C-G, Uhm K-O, Miura Y, Hosono T, Horike H, Khanna K K, Michikawa M.

Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons.

Mol Neurodegener, 6: 47, 2011.

 

 

2010年

 

Minagawa H, Watanabe A, Akatsu H, Adachi K, Ohtsuka C, Terayama Y, Hosono T, Takahashi S, Wakita H, Jung C-G, Komano H,

Michikawa M.

Homocysteine, another risk factor for Alzheimer's disease, impairs apolipoprotein E3 function.

J. Biol. Chem. 2010; 285:38382-38388.

 

Jung C-G, Horike H, Cha B-Y, Uhm K-O, Yamauchi R, Yamaguchi T, Hosono T, Iida K, Woo J-T, Michikawa M.

Honokiol increases ABCA1 expression level by activating retinoid X receptor β.

Biol. Pharm. Bull, 2010; 33:1105-1111.

 

2009年

 

Nakamura T, Watanabe A, Fujino T, Hosono T, and Michikawa M

Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

Mol. Neurodegener. 2009; 4: 35.

 

Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M, Doi M, Michikawa M, Takeuchi H, and Suzumura A

Microglia activated with toll-like receptor 9 ligand CpG attenuate oligomeric amyloid-β neurotoxicity in vitro and in vivo models of

Alzheimer's disease.

Am. J. Pathol. 2009; 175: 2121-2132.

 

Maeda T, Marutani T, Zou K, Araki W, Yagishita N, Yamamoto Y, Amano T, Michikawa M, Nakajima T, and Komano H

An E3 ubiquitin ligase, synoviolin is involved in the degradation of immature nicastrin, and regulates the production of amyloid β

protein.

FEBS J. 2009; 276: 5832-5840.

 

Zou K, Maeda T, Oba R, Komano H, and Michikawa M.

Aβ42-to-Aβ40- and angiotensin-converting activities in different domain of angiotensin-converting enzyme.

J. Biol. Chem. 2009; 284:31914-31920.

 

Tesseur I, Brecht W, Corn J, Gong J-S, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, and Wyss-Coray T.

Bioactive TGF-β can associate with lipoproteins and is enriched in those containing apolipoprotein E3.

J. Neurochem. 2009; 110(4): 1254-1262.

 

Minagawa H, Gong J-S, Jung C-G, Watanabe A, Lund-Katz S, Phillips M C, Saito H, Michikawa M.

Mechanism underlying apolipoprotein E isoform-dependent lipid efflux from neural cells in culture.

J. Neurosci. Res. 2009; 87: 2498-2508.

 

 

2008年

 

Zou K, Maeda T, Michikawa M, and Komano H

New amyloid plaques or a game of hide-and-seek?

Int. J. Biol. Sci. 2008; 4: 200-201

 

Zou K, Hosono T, NakamuraT, Shiraishi H, MaedaT, Komano H, Yanagisawa K, Michikawa M.

Novel role of presenilins in maturation and transport of integrin β1.

Biochemistry. 2008; 47(11): 3370-3378.

 

 

2007年

 

Zou K, Yamaguchi H, Akatsu H, Sakamoto T, Ko M, Mizoguchi K, Gong JS, Yu W, Yamamoto T, Kosaka K, Yanagisawa K,

Michikawa M.

Angiotensin-converting enzyme converts amyloid β-protein1-42 (Aβ(1-42)) to Aβ(1-40), and its inhibition enhances brain Aβ

deposition.

J. Neurosci. 2007; 27(32):8628-8635.

 

Gong JS, Morita SY, Kobayashi M, Handa T, Fujita SC, Yanagisawa K, Michikawa M.

Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons.

Mol. Neurodegener. 2007; 2:9.

 

Yamamoto N, Matsubara E, Maeda S, Minagawa H, Takashima A, Maruyama W, Michikawa M,, Yanagisawa K.

A ganglioside-induced toxic soluble Aβ assembly. Its enhanced formation from Aβ bearing the Arctic mutation.

J. Biol Chem. 2007; 282(4):2646-2655.

 

 

2006年

 

Yang SR, Kim SJ, Byun KH, Hutchinson B, Lee HH, Michikawa M, Lee YS, Kang KS.

NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 MAP

kinase signaling.

Stem Cells. 2006; 24(2):292-298.

 

Wollmer MA, Kapaki E, Hersberger M, Muntwyler J, Brunner F, Tsolaki M, Akatsu H, Kosaka K, Michikawa M,, Molyva D, Paraskevas

GP, Lutjohann D, von Eckardstein A, Hock C, Nitsh RM, Papassotiropoulos A.

Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease.

Am J Med Genet B Neuropsychiatr Genet. 2006; 141(5):534-536.

 

Byun K, Kim J, Cho S-Y, Hutchinson B, Yang S-R, Kang K-S, Cho M, Hwang K, Michikawa M, Jeon Y-W, Paik Y-K, and Lee B.

Alteration of the glutamate and GABA transporters in the hippocampus of the Niemann-Pick disease, type C mouse using

proteomic analysis.

Proteomics. 2006; 6(4):1230-1236.

 

 

2005年

 

Ko M, Zou K, Minagawa H, Yu W, Gong JS, Yanagisawa K, and Michikawa M.

Cholesterol-mediated neurite outgrowth is differently regulated between cortical and hippocampal neurons.

J. Biol. Chem. 2005; 280(52):42759-42765.

 

Yu W, Ko M, Yanagisawa K, Michikawa M.

Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: Implication of heterozygous NPC1 mutations being a

risk for tauopathy.

J. Biol. Chem. 2005; 280(29):27296-27302.

 

Yu W, Gong J-S, Ko M, Garver W. S., Yanagisawa K, and Michikawa M.

Altered cholesterol metabolism in Niemann-Pick Type C1 mouse brain affects mitochondria function.

J. Biol. Chem. 2005; 280(12): 11731-11739.

 

Yu W, Zou K, Gong JS, Ko M, Yanagisawa K, and Michikawa M.

Oligomerization of amyloid β-protein occurs during the isolation of lipid rafts.

J. Neurosci. Res. 2005; 80: 114-119.

 

Kim MJ, Kim J, Michikawa M, Cha CI, Lee B.

Substance P immunoreactive cell reductions in cerebral cortex of Niemann-Pick diseasse type C mouse.

Brain Res. 2005; 1043(1-2): 218-224.

 

 

2004年

 

Kamata T, Katsube K, Michikawa M, Yamada M, Takada S, Mizusawa H.

R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts

mutants.

Biochim Biophys Acta. 2004; 1676(1): 51-62.

 

Sawamura N, Ko M, Yu W, Zou K, Hanada K, Suzuki T, Gong JS, Yanagisawa K, Michikawa M.

Modulation of amyloid precursor protein cleavage by cellular sphingolipids.

J. Biol. Chem. 2004; 279(12):11984-11991.

 

Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K,

Matsuzaki K, Leemre CA, Selkoe DJ, Naiki H, Yanagisawa K.

A seed for Alzheimer amyloid in the brain.

J. Neurosci. 2004; 24(20):4894-4902.

 

 

2003年

 

Zou K, Kim D, Kakio A, Byun K, Gong JS, Kim M, Sawamura N, Nishimoto S, Matsuzaki K, Lee B, Yanagisawa K, and Michikawa M.

Amyloid β-protein (Aβ)1-40 protects neurons from damage induced by Aβ1-42 in culture and in rat brain.

J. Neurochem. 2003; 87: 609-619.

 

Sawamura N, Gong JS, Chang TY, Yanagisawa K, Michikawa M.

Promotion of tau phosphorylation by MAP Kinase Erk1/2 Is accompanied by reduced cholesterol level in detergent-insoluble

membrane fractions in Niemann-Pick C1-deficient cells.

J. Neurochem. 2003; 84:1086-1096.

 

Watabe K, Sakamoto T, Kawazoe Y, Michikawa M, Miyamoto K, Yamamura T, Saya H, Araki N.

Tissue culture methods to study neurological disorders: establishment of immortalized Schwann cells from murine disease models.

Neuropathology. 2003; 23(1): 68-78.

 

Sakaguchi N, Muramatsu H, Ichihara-Tanaka K, Maeda N, Noda M, Yamamoto T, Michikawa M, Ikematsu S, Sakuma S, Muramatsu

T.

Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent

survival of embryonic neurons.

Neurosci. Res. 2003; 45(2): 219-224.

 

 

2002年

 

Gong JS, Kobayashi M, Hayashi H, Zou K, Sawamura N, Fujita SC, Yanagisawa K, Michikawa M.

Apolipoprotein E (apoE) isoform- dependent lipid release from astrocytes prepared from human-apoE3- and apoE4-knock-in mice.

J. Biol. Chem. 2002; 277: 29919-29926.

 

Zou K, Gong JS, Yanagisawa K, Michikawa M.

A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage.

J. Neurosci. 2002; 22(12): 4833-4841.

 

Fan QW, Yu W, Gong JS, Zou K, Sawamura N, Senda T, Yanagisawa K, Michikawa M.

Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons.

J. Neurochem. 2002; 80: 178-190.

 

Gong JS, Sawamura N, Zou K, Sakai J, Yanagisawa K, Michikawa M.

Amyloid ?-protein affects cholesterol metabolism in cultured neurons: Implications for pivotal role of cholesterol in the amyloid

cascade.

J. Neurosci. Res. 2002; 70: 438-446.

 

Garver WS, Krishnan K, Gallagos JR, Michikawa M, Francis GA, Heidenreich RA.

Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae.

J. Lipid Res. 2002; 43(4):579-589.