EVALUATION OF THE PLACENTAL LIPID PEROXIDES, GLUTATHION PEROXIDES ACTIVITIES AND THEIR RELATIONSHIP WITH SERUM LIPOPOPROTEINS IN PREECLAMPTIC AND ECLAMPTIC PREGNANCIES
Department of Obstetrics and Gynecology, Medical Faculty, Dicle University. Diyarbakir-Turkey
(Address of Correspondence:) Gokhan BAYHAN
M.D., Assistant Professor of Ob./Gyn.,
Dicle University, School of Medicine
Diyarbakir, TURKEY
Phone: 00-90-412-2488430
E-Mail: bayhan@tr-net.net.tr
Source
Nagoya Medical Journal 43(2):53-64, 1999
Abstract
Placental production of lipid peroxides (LPO) and levels of serum lipoproteins increase abnormally in preeclampsia (PE) and eclampsia (E). The cause of it is not known, but if placental antioxidant enzymes are deficient, lipid peroxides will increase. This study has examined any evidence of increased placental lipid peroxidation and accumulation of malonydialdehyde (MDA, an end product of LPO) in preeclamptic or eclamptic women and any relationship between the elevated MDA or lipoproteins and lower antioxidants in healthy pregnant women. Placental tissues and blood samples were obtained from normal (n=44), preeclamptic (n=27), eclamptic (n=18) pregnancies immediately after delivery. The levels of triglyceride (TG), total cholesterol (T.Chol), high density lipoprotein-cholesterol (HDL-C) and placental LPO, glutathione peroxidase (GSH-Px), glutathione (GSH) were measured seperately.
GSH-Px activity and the levels of glutathione (GSH) were significantly lower in preeclamptic and eclamptic pregnancies than in normal placentas (p<0.0001). Lipid peroxides were significantly higher in the placentas of preeclamptic and eclamptic pregnancies than those of normal subjects (p<0.0001). The levels of serum TG were significantly higher in the PE and E group than those in the control group (p<0.0001). The levels of HDL in preeclamptic and eclamptic patients were significantly lower than those of control group (p<0.001), but the levels of LDL did not show a significant difference between the groups (p>0.05). The levels of serum T.Chol in preeclamptic and eclamptic pregnancies were significantly higher than those in the control group (p<0.0001).
In preeclamptic group was found no correlation between the level of placental MDA and serum lipoproteins. However, in eclamptic group a significant positive correlation was noted between the appearance of placental MDA and the level of serum trigliyceride (p<0.001). Also, a negative correlation was obtained between the level of serum HDL and placental MDA in eclamptic group (p<0.02).
