Recent publications (Selected from 2003-)

2008

Iigo, M., Alexander, D.B., Long, N., Xu, J., Fukamachi, K., Futakuchi, M., Takase, M. and Tsuda, H. (2008) Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine. Biochimie, in press. (Abstract )

Tamano, S., Sekine, K., Takase, M., Yamauchi, K., Iigo, M. and Tsuda, H. (2008) Lack of Chronic Oral Toxicity of Chemopreventive Bovine Lactoferrin in F344/DuCrj Rats. Asian Pac J Cancer Prev, 9, 313-316. (Abstract )

Ueda, S., Kawamata, M., Teratani, T., Shimizu, T., Tamai, Y., Ogawa, H., Hayashi, K., Tsuda, H. and Ochiya, T. (2008) Establishment of rat embryonic stem cells and making of chimera rats. PLoS ONE, 3, e2800. (Abstract )

Fukamachi, K., Imada, T., Ohshima, Y., Xu, J. and Tsuda, H. (2008) Purple corn color suppresses Ras protein level and inhibits 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat. Cancer Sci, 99, 1841-1846. (Abstract )

Kurosawa, G., Akahori, Y., Morita, M., Sumitomo, M., Sato, N., Muramatsu, C., Eguchi, K., Matsuda, K., Takasaki, A., Tanaka, M., Iba, Y., Hamada-Tsutsumi, S., Ukai, Y., Shiraishi, M., Suzuki, K., Kurosawa, M., Fujiyama, S., Takahashi, N., Kato, R., Mizoguchi, Y., Shamoto, M., Tsuda, H., Sugiura, M., Hattori, Y., Miyakawa, S., Shiroki, R., Hoshinaga, K., Hayashi, N., Sugioka, A. and Kurosawa, Y. (2008) Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic. Proc Natl Acad Sci U S A, 105, 7287-7292. (Abstract )

Matsuoka, Y., Fukamachi, K., Uehara, N., Tsuda, H. and Tsubura, A. (2008) Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis. Cancer Sci, 99, 309-315. (Abstract )

2007

Matsuoka, Y., Hamaguchi, T., Fukamachi, K., Yoshida, M., Watanabe, G., Taya, K., Tsuda, H. and Tsubura, A. (2007) Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention. Med Mol Morphol, 40, 185-190.(Abstract ) 

Naiki-Ito, A., Asamoto, M., Hokaiwado, N., Takahashi, S., Yamashita, H., Tsuda, H., Ogawa, K. and Shirai, T. (2007) Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens. Cancer Res, 67, 11353-11358.(Abstract )

Ohnishi, T., Fukamachi, K., Ohshima, Y., Jiegou, X., Ueda, S., Iigo, M., Takasuka, N., Naito, A., Fujita, K., Matsuoka, Y., Izumi, K. and Tsuda, H. (2007) Possible Application of Human c-Ha-ras Proto-Oncogene Transgenic Rats in a Medium-Term Bioassay Model for Carcinogens.Toxicol Pathol, 35, 436-443. (Abstract)

Tsuda, H., Iigo, M., Takasuka, N., Ueda, S., Ohshima, Y., Fukamachi, K., Shirai, T., Hirano, S., Matsuda, E. and Wakabayashi, K. (2007) Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats. Food Chem Toxicol, 45, 1013-1019. (Abstract )

2006

Ueda, S., Fukamachi, K., Matsuoka, Y., Takasuka, N., Takeshita, F., Naito, A., Iigo, M., Alexander, D.B., Moore, M.A., Saito, I., Ochiya, T. and Tsuda, H. （2006） Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas. Carcinogenesis, 27 , 2497-2510. (Abstract)

Suzuki, R., Kohno, H., Suzui, M., Yoshimi, N., Tsuda, H., Wakabayashi, K. and Tanaka, T. (2006) An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies. Carcinogenesis, 27, 619-630.(Abstract)

Hamaguchi, T., Matsuoka, Y., Bechberger, J., Ohnishi, T., Fujita, K., Naus, C.C., Kusunoki, M., Tsubura, A. and Tsuda, H. (2006) Establishment of an apoptosis-sensitive rat mammary carcinoma cell line with a mutation in the DNA-binding region of p53. Cancer Lett, 232, 279-288.(Abstract)

2005

Morimura, K., Kang, J.S., Wei, M., Wanibuchi, H., Tsuda, H. and Fukushima, S. (2005) Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol , 33 , 764-767. (Abstract)

Goldberg, G.S., Kunimoto, T., Alexander, D.B., Suenaga, K., Ishidaate, F., Miyamoyo K., Ushijima T., Teng, C.T., Yokota, J., Phta, T. and Tsuda, H. (2005) Full Length and Dalta Lactoferrin Display Differential Cell Localization Dynamics, but do not Act as Tumor Markers or Significantly Affect the Expression of other Genes. Medicinal Chem. 1 :57-64.(Abstract)

2004

Hamaguchi, T., Matsuoka, Y., Kawaguchi, H., Fukamachi, K., Takasuka, N., Ueda, S., Shimizu, K., Ohki, M., Kusunoki, M., Sakakura, T., Yoshida, H. and Tsuda, H. Terminal endbuds and acini as the respective major targets for chemical and sporadic carcinogenesis in the mammary glands of human c-Ha-ras proto-oncogene transgenic rats. Breast Cancer Res. Treat. , 83: 43-56, 2004. (Abstract )

Iigo, M., Shimamura, M., Matsuda, E., Fujita, K., Nomoto, H., Satoh, J., Kojima, S., Alexander, D.B., Moore, M.A. and Tsuda, H. Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis. Cytokine , 25: 36-44, 2004. (Abstract)

Park, C.B., Fukamachi, K., Takasuka, N., Han, B.S., Kim, C.K., Hamaguchi, T., Fujita, K., Ueda, S. and Tsuda, H. Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate. Cancer Sci. ,2004, 205-210. (Abstract)

Naito, A., Suzuki,A., Ueda, S., Nomoto, H., Toriyama-Baba, H., Asamoto, M., and Tsuda, H. Preferential Mammary Carcinogenic Effects of 2-amino-1-methl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Human c-Ha-Ras Proto-oncogene Transgenic Rats, Cancer Sci. , 399-403, 2004. (Abstract)

Fukamachi, K., Han, B-S., Kim, C-K., Takasuka, N., Matsuoka, Y., Matsuda, E., Yamasaki, T. and Tsuda, H. Possible Enhancing effects of atrazine and nonylphenol on 7,12-dimethylbenz[a]anthracene-induced mammary tumor development in human c-Ha-ras proto-oncogene transgenic rats, Cancer Sci. , 404-410, 2004. (Abstract)

Alexander, D.B., Ichikawa, H., Bechberger, J.F., Valiunas, V., Ohki, M., Naus, C.C., Kunimoto, T., Tsuda, H., Miller, W.T., Goldberg, G.S. Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity. Cancer Res. , 64(4): 1347-1358, 2004. (Abstract)

Shimamura, M., Yamamoto, Y., Ashino, H., Oikawa, T., Hazato, T., Tsuda, H., Iigo, M. Bovine lactoferrin inhibits tumor-induced angiogenesis. Int J Cancer , 111(1): 111-116, 2004. (Abstract)

Fujita. K-I, Matsuda, E., Sekine, K., Iigo, M., Tsuda, H. Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats, Carcinogenesis , 25(8): 1961-1966, 2004. (Abstract)

Kohno, H., Suzuki, R., Sugie, S., Tsuda, H. and  Tanaka, T. Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats. Cancer Sci . 95(4):300-305, 2004. (Abstract )

Fukushima, S., Wanibuchi, H., Morimura, K., Iwai, S., Nakae, D., Kishida, H., Tsuda, H., Uehara, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M. and  Furukawa, F. Existence of a Threshold for Induction of Aberrant Crypt Foci in the Rat Colon with Low Doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine. Toxicol. Sci. 80(1):109-114, 2004. (Abstract)

Tsuda, H., Ohshima, Y., Nomoto, H., Fujita, K., Matsuda, E., Iigo M., Takasuka N. and Moore M.A. Cancer Prevention by Nutural Compounds. Drug Metab. Pharmacokin. 19(4):245-263, 2004. (Abstract)

Fujita, K., Matsuda, E., Sekine, K., Iigo, M., Tsuda, H. Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat. Cancer Lett .15:213(1) 21-29, 2004. (Abstract)

Nomoto, H., Iigo, M., Hamada, H., Kojima, S. and Tsuda, H. Chemoprevention of colorectal by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Nurtriton and Cancer , 49(1) 81-88, 2004. (Abstract)

2003

Tsuda, H., Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Imaida, K., Tatematsu, M., Hirose, M., Wakabayashi, K. and Moore, M.A. Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. Toxicol. Pathol. , 31: 80-86, 2003. (Abstract)

Tanaka, T., Kohno, H., Nomura, E., Taniguchi, H., Tsuno, T. and Tsuda, H. A novel geranylated derivative, ethyl 3-(4’-geranyloxy-3’-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue. Oncology , 64:166-175, 2003. (Abstract)

Moore, M.A., Tajima, K. and Tsuda, H. Epidemiology of the major cancers in the Asian Pacific. Proc. Jpn. Acad. , 79: 27-33, 2003.

Fukushima, S., Wanibuchi, H., Morimura, K., Wei, M., Nakae, D., Konishi, Y., Tsuda, H., Takasuka, N., Imaida, K., Shirai, T., Tatematsu, M., Tsukamoto, T., Hirose, M. and Furukawa, F. Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Lett. , 191: 35-40, 2003. (Abstract)

Fukushima, S., Moore, M.A., Tsuda, H. Appropriate models and an understanding of carcinogenic mechanisms-requirements for hazard risk assessment. Asian Pacific J. Cancer Prev. , 4: 75-78, 2003. (Abstract)

Moore, M.A., Kunimoto, T., and Tsuda, H. Cancer screening literature in the period 2000-2002: Pointers to future research avenues. Asian Pacific J. Cancer Prev. , 4: 57-60, 2003. (Abstract)

Tsuda, H., Naito, A., Kim, C.K., Fukamachi, K., Nomoto, H. and Moore, M.A. Carcinogenesis and its modification by environmental endocrine disruptors: In vivo experimental and epidemiological findings. Jpn. J. Clin. Oncol. , 33: 259-270, 2003. (Abstract)

Matsuoka, Y., Fukamachi, K., Hamaguchi, T., Toriyama-Baba, H., Kawaguchi, H., Kusunoki, M., Yoshida H., and Tsuda, H.　Rapid emergence of mammary preneoplastic and malignant lesions in human c-Ha-ras proto-oncogene transgenic rats: possible application for screening of chemopreventive agents. Toxicol. Pathol. , 31: 632-637, 2003. (Abstract)

Moore, M.A., Tajima, K., Anh, P.H., Aydemir, G., Basu, P.S., Bhurgri, Y., Chen, K., Gajalakshmi, V., Hirose, K., Mosavi-Jarrahi, A., Ngoan, L.T., Qiao, Y.L., Shin, H.R., Sriamporn, S., Srivatanakul, P., Tokudome, S., Yoo, K.Y. and Tsuda, H. Grand challenges in global health and the practical prevention program? Asian focus on cancer prevention in females of the developing world. Asian Pacific J Cancer Prev. , 4: 153-165, 2003. (Abstract)

Goldberg, G.S., Alexander, D.B., Pellicena, P., Zhang, Z-Y., Tsuda, H. and Miller, W.T. Src phosphorylates cas on tyrosine 253 to promoto migration of transformed cells. J. Biol. Chem. , 278: 46533-46540, 2003. (Abstract)

Hokaiwado, N., Asamoto, M., Cho, Y-M., Tsuda, H. and Shirai, T. Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats. Cancer Sci ., 94:1042-1045, 2003. (Abstract )