・Phylogenetic analysis of Bacillus cereus isolates from severe systemic infections using multilocus sequence typing scheme.

Vassileva M, Torii K, Oshimoto M, Okamoto A, Agata N, Yamada K, Hasegawa T, Ohta M. 

Microbiol Immunol. 2006; 50: 743-749.


・Use of a combination of brushing technique and the loop-mediated isothermal amplification method as a novel, rapid, and safe system for detection of Helicobacter pylori.

Minami M, Ohta M, Ohkura T, Ando T, Torii K, Hasegawa T, Goto H. 

J Clin Microbiol. 2006; 44: 4032-4037.


・Growth phase dependent effect of clindamycin on production of exoproteins by Streptococcus pyogenes.

Sawai J, Hasegawa T, Kamimura T, Okamoto A, Ohmori D, Nosaka N, Yamada K, Torii K, Ohta M.

Antimicrob Agents Chemother. 2007; 51: 461-467.


・Analysis of twin-arginine translocation pathway homologue in Staphylococcus aureus.

Yamada K, Sanzen I, Ohkura T, Okamoto A, Torii K, Hasegawa T, Ohta M. 

Curr Microbiol. 2007; 55: 14-19.


・A new phylogenetic cluster of cereulide-producing Bacillus cereus strains.

Vassileva M, Torii K, Oshimoto M, Okamoto A, Agata N, Yamada K, Hasegawa T, Ohta M.

J Clin Microbiol. 2007;45:1274-1277.


・Characterization of the NAD-glycohydrolase in Streptococcal strains.

Tatsuno I, Sawai J, Okamoto A, Matsumoto M, Minami M, Isaka M, Ohta M, Hasegawa T.

Microbiology 2007, 153:4253-4260.


・Post-colonoscopic Listeria septicemia in ulcerative colitis during immunosuppressive therapy.

Minami M, Hasegawa T, Ando T, Maeda O, Ohkura T, Ohta M, Goto H.

Intern Med. 2007, 46:2023-2027.


・Induction of immune responses and prevention of alveolar bone loss by intranasal administration of mice with Porphyromonas gingivalis fimbriae and recombinant cholera toxin B subunit.

Takahashi Y, Kumada H, Hamada N, Haishima Y, Ozono S, Isaka M, Yasuda Y, Tochikubo K, Umemoto T.

Oral Microbiol Immunol. 2007 Dec;22(6):374-80.


・Protective effect of nasal immunization of influenza virus hemagglutinin with recombinant cholera toxin B subunit as a mucosal adjuvant in mice.

Isaka M, Zhao Y, Nobusawa E, Nakajima S, Nakajima K, Yasuda Y, Matsui H, Hasegawa T, Maeyama J, Morokuma K, Ohkuma K, Tochikubo K.

Microbiol Immunol. 2008 52:55-63.


・Systemic and mucosal immune responses in mice after intranasal immunizaion with pneumococcal polysaccharide conjugate vaccines with recombinant cholera toxin B subunit as an adjuvant.

Kutsuna T, Isaka M,.

Nagoya Med.J 2008;49,135-148.


Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus.

Nagao M, Okamoto A, Yamada K, Hasegawa T, Hasegawa Y, Ohta M.

BMC Microbiol. 2009 9:52.


・Seroprevalence of Fusobacterium varium in ulcerative colitis patients in Japan.

Minami M, Ando T, Okamoto A, Sasaki N, Ohkura T, Torii K, Hasegawa T, Ohta M, Goto H.

FEMS Immunol Med Microbiol. 2009 56:67-72.


・Nationwide epidemiological study revealed the dissemination of methicillin-resistant Staphylococcus aureus carrying a specific set of virulence-associated genes in Japanese hospitals.

Ohkura T, Yamada K, Okamoto A, Baba H, Ike Y, Arakawa Y, Hasegawa T, Ohta M.

J Med Microbiol. 2009 58:1329-1336.


・Transmission of bacterial infections to healthcare workers during intubation and respiratory care of patients with severe pneumonia.

Baba H, Iinuma Y, Imaizumi K, Hasegawa Y, Hasegawa T, Ohta M, Paterson DL.

Infect Control Hosp Epidemiol. 2009 30:1019-1021


・The streptococcal inhibitor of complement (SIC) protects Streptococcus pyogenes from bacteriocin-like inhibitory substance (BLIS) from Streptococcus salivarius.

Minami M, Ohmori D, Tatsuno I, Isaka M, Kawamura Y, Ohta M, Hasegawa T.

FEMS Microbiol Lett. 2009 298:67-73.


・Effect of cyclic bis(3'-5') diguanylic acid and its analogs on bacterial biofilm formation.

Ishihara Y, Hyodo M, Hayakawa Y, Kamegaya T, Yamada K, Okamoto A, Hasegawa T, Ohta M.

FEMS Microbiol Lett 301:193-200, 2009


・The mucosal adjuvanticity of the oligodeoxynucleotides containing a non-methylated CpG motif on BCG and diphtheria toxoid.

Maeyama J, Komiya T, Takahashi M, Isaka M, Goto N, Yamamoto S.

Vaccine. 27(8):1166-73, 2009


・Clindamycin-induced CovS-mediated regulation of the production of virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes.

Minami M, Kamimura T, Isaka M, Tatsuno I, Ohta M, Hasegawa T.

Antimicrob Agents Chemother. 54, 98-102, 2010


・Evaluation of selection media for the detection of borderline MRSA.

Yamada K, Inuzuka K, Tatsumi N, Sanzen I, Ohkura T, Okamoto A, Hasegawa T, Ohta M.

J Infect Chemother.16, 19-24, 2010.


・Characterization of a virulence-associated and cell-wall-located DNase of Streptococcus pyogenes.

Hasegawa T, Minami M, Okamoto A, Tatsuno I, Isaka M, Ohta M.

Microbiology 156, 184-190, 2010.


・Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients.

Hasegawa T, Okamoto A, Kamimura T, Tatsuno I, Hashikawa S, Yabutani M, Matsumoto M, Yamada K, Isaka M, Minami M, Ohta M.

APMIS 118, 167-78, 2010.


・Characterization of Streptococcus pyogenes isolated from balanoposthitis patients presumably transmitted by penile-oral sexual intercourse.

Minami M, Wakimoto Y, Matsumoto M, Matsui H, Kubota Y, Okada A, Isaka M, Tatsuno I, Tanaka Y, Hasegawa T.

Curr Microbiol 61, 101-105, 2010.


・NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates.

Tatsuno I, Isaka M, Minami M, Hasegawa T.

BMC Microbiol. 10:144, 2010.


・Prevalence of a Streptococcal inhibitor of a complement-mediated
cell lysis-like gene (sicG) in Streptococcus dysgalactiae subsp. equisimilis.

Minami M, Ichikawa M, Matsui H, Hata N, Wakiyama N, Matsumoto M, Ohta M,
Hasegawa T.

Curr Microbiol. 62:884-887, 2011.


・M Application of both high-performance liquid chromatography combined with tandem mass spectrometry shotgun and 2-D polyacrylamide gel electrophoresis for streptococcal exoproteins gave reliable proteomic data.

Okamoto A, Hasegawa T, Yamada K, Ohta

Microbiol Immunol. 55:84-94, 2011.


・Clinical and microbiological analysis of beta hemolytic streptococci during 2006-2010 at Nagoya City University Hospital.

Ichikawa M, Minami M, Ohashi M, Wakimoto Y, Matsui H, Hasegawa T.

Nagoya Med J. 51:175-189, 2011.


・Variation in M protein production among Streptococcus pyogenes strains according to emm genotype.

Matsumoto M, Suzuki M, Hirose K, Hiramatsu R, Minagawa H, Minami M,
Tatsuno I, Okamoto A, Ohta M, Hasegawa T.

Microbiol Immunol. 55:379-387, 2011.


・Protective effect of Hainosankyuto, a traditional Japanese medicine, on Streptococcus pyogenes infection in murine model.

Minami M, Ichikawa M, Hata N, Hasegawa T.

PLoS One. 6(7):e22188, 2011.


・Analysis of two-component sensor proteins involved in response to acid stimuli in Streptococcus pyogenes.

Ichikawa M, Minami M, Isaka M, Tatsuno I, Hasegawa T.

Microbiology 157:3187-94, 2011.


・Analysis of the pathological lesions of the lung in a mouse model of cutaneous infection with Streptococcus pyogenes.

Minami M, Sobue S, Ichihara M, Hasegawa T.

Pathol Int. 2012 Feb;62(2):99-104.


・The cell envelope-associated protein, LytR, regulates the cysteine protease SpeB in Streptococcus pyogenes.

Minami M, Ichikawa M, Ohta M, Hasegawa T.

APMIS. 2012 May;120(5):417-26.


・Characterization of NADase-inactive NAD+ glycohydrolase in Streptococcus pyogenes.

Tatsuno I, Isaka M, Hasegawa T.

Advances in Microbiology 2013, 3(1), 91-100


・Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease.

Tatsuno I, Okada R, Zhang Y, Isaka M, Hasegawa T.

BMC Res Notes. 2013 Mar 28;6(1):126.


・Simultaneous isolation of emm89-type Streptococcus pyogenes strains with a wild-type or mutated covS gene from a single streptococcal toxic shock syndrome patient.

Masuno K, Okada R, Zhang Y, Isaka M, Tatsuno I,Shibata S, Hasegawa T.

J. Med. Microbiol. (2014), 63, 504–507


・Emergence of type I restriction modification system-negative emm1 type Streptococcus pyogenes clinical isolates in Japan.

Okada R, Matsumoto M, Zhang Y, Isaka M, Tatsuno I, Hasegawa T.

APMIS in press


・Relevance of the two-component sensor protein CiaH to acid and oxidative stress responses in Streptococcus pyogenes.

Tatsuno I, Isaka M, Okada R, Zhang Y, Hasegawa T.

BMC Res Notes in press

論文

Publications List