病態生化学

Exposure to High Glucose Concentration Decreases Cell Surface ABCA1 and HDLBiogenesis in Hepatocytes.
Tsujita M, Hossain MA, Lu R, Tsuboi T, Okumura-Noji K, Yokoyama S.
J Atheroscler Thromb. 2017 Nov 1;24(11):1132-1149. doi: 10.5551/jat.39156. Epub 2017 Apr 19.

Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice.
Ishida N, Ishihara Y, Ishida K, Tada H, Funaki-Kato Y, Hagiwara M, Ferdous T, Abdullah M, Mitani A, Michikawa M, Matsushita K.
NPJ Aging Mech Dis. 2017 Nov 6;3:15. doi: 10.1038/s41514-017-0015-x. eCollection 2017.

Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory.
Yoshikawa M, Soeda Y, Michikawa M, Almeida OFX, Takashima A.
Front Neurosci. 2018 Mar 1;12:124. doi: 10.3389/fnins.2018.00124. eCollection 2018.

細胞生理学

Lee K, Isogai A, Antoh M, Kajioka S, Eto M, Hashitani H (2018). Role of K+ channels in regulating spontaneous activity in the muscularis mucosae of guinea pig bladder. Eur J Pharmacol. 818, 30-37

Ohguchi H, Mitsui R, Imaeda K, Joh T, Hashitani H (2017). Mechanisms of PTHrP-induced inhibition of smooth muscle contractility in the guinea pig gastric antrum. Neurogastroenterol Motil. 29(12). doi: 10.1111/nmo.13142.

van Helden DF, Kamiya A, Kelsey S, Laver DR, Jobling P, Mitsui R, Hashitani H (2017). Nerve-induced responses of mouse vaginal smooth muscle. Pflugers Arch. 469(10):1373-1385.

Fukuta H, Mitsui R, Takano H, Hashitani H (2017). Contractile properties of periosteal arterioles in the guinea-pig tibia. Pflugers Arch. 469(9):1203-1213.

Mitsui R, Hashitani H (2017). Properties of synchronous spontaneous Ca2+ transients in the mural cells of rat rectal arterioles. Pflugers Arch. 469(9):1189-1202.

Takeya M, Hashitani H, Hayashi T, Higashi R, Nakamura KI, Takano M (2017). Role of mucosa in generating spontaneous activity in the guinea pig seminal vesicle. J Physiol. 595(14):4803-4821.

Hashitani H, Nguyen MJ, Noda H, Mitsui R, Higashi R, Ohta K, Nakamura KI, Lang RJ (2017). Interstitial cell modulation of pyeloureteric peristalsis in the mouse renal pelvis examined using FIBSEM tomography and calcium indicators. Pflugers Arch. 469(5-6):797-813.

免疫学

免疫学分野では、制御性T細胞と樹状細胞の相互関係や、紫外線などの外部環境が免疫機能にどのような影響を与えるのか、マウスモデルを用いて解析している。皮膚や全身性の自己免疫疾患に対する新たな治療法の開発を目指している。

Yamazaki S, Odanaka M, Nishioka A, Kasuya S, Shime H, Hemmi H, Imai M, Riethmacher D, Kaisho T, Ohkura N, Sakaguchi S, Morita A. Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin. J Immunol. 200(1):119-129. 2018

細菌学

1. Functional Predominance of msr(D), Which Is More Effective as mef(A)-Associated Than mef(E)-Associated, Over mef(A)/mef(E) in Macrolide Resistance in Streptococcus pyogenes.
Tatsuno I, Isaka M, Masuno K, Hata N, Matsumoto M, Hasegawa T.
Microb Drug Resist. 2018 Feb 6. doi: 10.1089/mdr.2017.0277. [Epub ahead of print]
PMID: 29406792
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2. Female GADD34 mice develop age-related inflammation and hepatocellular carcinoma.
Nishio N, Hasegawa T, Tatsuno I, Isaka M, Isobe KI.
Geriatr Gerontol Int. 2017 Dec;17(12):2593-2601. doi: 10.1111/ggi.13080. Epub 2017 Jun 21.
PMID: 28635009
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3. Characterisation of clinically isolated Streptococcus pyogenes from balanoposthitis patients, with special emphasis on emm89 isolates.
Hasegawa T, Hata N, Matsui H, Isaka M, Tatsuno I.
J Med Microbiol. 2017 Apr;66(4):511-516. doi: 10.1099/jmm.0.000460.
PMID: 28463666
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分子神経生物学

Neuroprotective erythropoietin attenuates microglial activation, including morphological changes, phagocytosis, and cytokine production.
Tamura T, Aoyama M, Ukai S, Kakita H, Sobue K, Asai K.
Brain Res. 2017;1662:65-74. doi: 10.1016/j.brainres.2017.02.023.

再生医学

脳の複雑な機能は、ニューロンが形成する複雑な神経回路を基盤としたものです。ニューロンの大部分は胎生期に産生されますが、一部の特殊な領域では生後の脳内でも少数のニューロンが産生されています。再生医学分野では、生後の脳内で新生するニューロンが、脳梗塞や大脳皮質傷害後の脳内でニューロンを再生する過程とその制御メカニズムの研究を行っています。
【原著論文】
1. Sawada M, Ohno N, Kawaguchi M, Huang SH, Hikita T, Sakurai Y, Nguyen HB, Thai TQ, Ishido Y, Yoshida Y, Nakagawa H, Uemura A, Sawamoto K. PlexinD1 signaling controls morphological changes and migration termination of new neurons. EMBO J 37(2): e97404. (17 Jan 2018) doi:10.15252/embj.201797404.
2. Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pe´rez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, Garci´a-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K. Radial glial fibers support neuronal migration and regeneration after neonatal brain injury. Cell Stem Cell 22(1): 128-137. (4 Jan 2018) doi:10.1016/j.stem.2017.11.005.
　

病態モデル医学

MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α Cells In Vivo.
Katoh MC, Jung Y, Ugboma CM, Shimbo M, Kuno A, Basha WA, Kudo T, Oishi H, Takahashi S.
Mol Cell Biol. 2018 Mar 29;38(8). pii: e00504-17. doi: 10.1128/MCB.00504-17. Print 2018 Apr 15.

MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
Shawki HH, Oishi H, Usui T, Kitadate Y, Basha WA, Abdellatif AM, Hasegawa K, Okada R, Mochida K, El-Shemy HA, Muratani M, Ogura A, Yoshida S, Takahashi S.
PLoS One. 2018 Jan 11;13(1):e0190800. doi: 10.1371/journal.pone.0190800. eCollection 2018.

Isl1β Overexpression With Key β Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin Production and Secretion.
Jung Y, Zhou R, Kato T, Usui JK, Muratani M, Oishi H, Heck MMS, Takahashi S.
Endocrinology. 2018 Feb 1;159(2):869-882. doi: 10.1210/en.2017-00663.

MafB is a critical regulator of complement component C1q.
Tran MTN, Hamada M, Jeon H, Shiraishi R, Asano K, Hattori M, Nakamura M, Imamura Y, Tsunakawa Y, Fujii R, Usui T, Kulathunga K, Andrea CS, Koshida R, Kamei R, Matsunaga Y, Kobayashi M, Oishi H, Kudo T, Takahashi S.
Nat Commun. 2017 Nov 22;8(1):1700. doi: 10.1038/s41467-017-01711-0.

Transcription factor MafB may play an important role in secondary hyperparathyroidism.
Morito N, Yoh K, Usui T, Oishi H, Ojima M, Fujita A, Koshida R, Shawki HH, Hamada M, Muratani M, Yamagata K, Takahashi S.
Kidney Int. 2018 Jan;93(1):54-68. doi: 10.1016/j.kint.2017.06.023. Epub 2017 Sep 28.

視覚科学

Hirahara S, Nozaki M, Ohbayashi M, Hasegawa N, Ozone D, Ogura Y. Suppression of Retinal Neovascularization by Anti-CCR3 Treatment in an Oxygen-Induced Retinopathy Model in Mice. Ophthalmic Res. 2017;58(1):56-66. doi: 10.1159/000463238. Epub 2017 Apr 5.
Arai KI, Yasukawa T, Kato A, Kubota A, Usui H, Takase N, Kuwayama S, Ogura Y. Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Corneal Neovascularization in Rabbits. Ophthalmic Res. 2018;59(3):170-175. doi: 10.1159/000487054. Epub 2018 Mar 13.