第1解剖学講座

1. Kanai, M., Watari, N., Soji, T., and Sugawara, E., Formation and accumulation of lipolysosomes in developing chick hepatocytes. Cell. Tis. Res., 275:125-132, 1994

2. Soji, T., Sirasawa, N., Kurono, C., Yashiro, T., and Herbert, D.C., Immunohistochemical study of the post-natal development of the folliculo-stellate cells in the rat anterior pituitary gland. Tissue Cell, 26:1-8, 1994

3. Kurono, C., Nozaki, M., Ohguchi, H., Soji, T., and Herbert, D.C., Septate-like junctions in the normal male rat pituitary gland. Tissue Cell, 26:913-916, 1994


第1生化学講座

1. Zhou, X.-R., Suzuki, T., Shimizu, H., and Nishino, H., Amygdala kindling activates the phosphorylation of Ca2+/calmodulin-dependent protein kinase in rat hippocampus. Neurosci. Lett., 171:45-48, 1994


第2生理学講座

1. Hashimoto, N., Matsumoto, T., Mabe, H., Hashitani, T., and Nishino H., Dopamine had inhibitory and accelerating effects on ischemia induced neuronal cell damage in the rat striatum. Brain Res. Bull., 33:281-288, 1994

2. Aihara, N., Mizukawa, K., Koide, K., Mabe, H., and Nishino, H., Striatal grafts in infarct striatopallidum increase GABA release, reorganize GABAA receptor and improve water-maze learning in the rat. Brain Res. Bull., 33:483-488, 1994 3. Czurko, A., and Nishino, H., Appearance of immunoglobulin G and complement factor C3 in the striatum after transient focal ischemia in the rat. Neurosci. Lett., 166:51-54, 1994

4. Nishino, H., Czurko, A., Fukuda, A., Hashitani, T., Hida, H., Karadi, Z., and Lenard, L., Pathophysiological process after transient ischemia of the middle cerebral artery in the rat. Brain Res. Bull., 35:51-56, 1994

5. Matsumoto, I., Oomura, Y., Nishino, H., Nemoto, S., Aou, S., and Aikawa, T., Effects of 2-buten-4-olide, an endogenous satiety substance, on plasma glucose, corticosterone, and catecholamines. Am. J. Physiol., 266:R413-R418, 1994 6. Zhou, X.R., Suzuki, T., Shimizu, H., and Nishino, H., Amygdala kindling activates the phosphorylation of Ca2+/calmodulin-dependent protein kinase in rat hippocampus. Neurosci. Lett., 171:45-48, 1994

7. Hattori, S., Naoi, M., and Nishino, H., Striatal dopamine turnover during treadmill running in the rat: relation to the speed of running. Brain Res. Bull., 35:41-49, 1994

8. Stork, O., Kumazaki, M., Nishino, H., and Obata, K., 6-Hydroxydopamine lesion prevents induction of tyrosine hydroxylase by haloperidol in the rat substantia nigra, pars reticulata. Proc. Jpn. Acad., 70(B):92-95, 1994

9. Nishino, H., Czurko, A., Onizuka, K., Fukuda, A., Hida, H., Ungsuparkorn, C., Kunimatsu, M., Sasaki, M., Karadi, Z., and Lenard, L., Neuronal damage following transient cerebral ischemia and its restoration by neural transplant. Neurobiology, 2:223-234, 1994

10. Oomura, Y., Karadi, Z., Nishino, H., Aou, S., and Scott, T.R., Functional correlation between feeding-related neurons and chemical senses. Olfaction and Taste XI (Eds. Kurihara, K., Suzuki, N., and Ogawa, H.) Springer-Verlag, Tokyo, pp. 502-506, 1994


第1病理学講座

1. Asakawa, E., Hirose, M., Hagiwara, A., Takahashi, S., and Ito, N., Carcinogenicity of 4-methoxyphenol and 4-methylcatechol in F344 rats. Int. J. Cancer., 56:146-152, 1994.

2. Yoshida, Y., Hirose, M., Takaba, K., Kimura, J., and Ito, N., Induction and promotion of forestomach tumors by sodium nitrite in combination with ascorbic acid or sodium ascorbate in rats with or without N-methyl-N'-nitro-N-nitrosoguanidine pre-treatment. Int. J. Cancer., 56:124-128, 1994.

3. Kawabe, M., Takaba, K., Yoshida,Y., and Hirose, M., Effects of combined treatment with phenolic compounds and sodium nitrite on two-stage carcinogenesis and cell proliferation in the rat stomach. Jpn. J. Cancer Res., 85:17-25, 1994.

4. 溝口正枝、加藤俊男、小川久美子、長尾静子、高橋英久、荒井昌之。ヌ−ドマウス移植腫瘍におよぼす純エタノ−ル局注の影響。 J. Toxicol. Pathol., 7:61-65, 1994.

5. Hasegawa, R., Miyata, E., Futakuti, M., Hagiwara, A., Nagao, M., Sugimura, T., and Ito, N., Synergistic enhancement of hepatic foci development by combined treatment of rats with 10 heterocyclic amines at low doses. Carcinogenesis., 15(5):1037-1041, 1994.

6. Shioya, S., Nagami-Oguihara, R., Kimura, T., Imaida, K., and Fukushima, S., Roles of bladder distension, urinary pH and sodium ion concentration in cell proliferation of bladder epithelium in rats ingesting sodium salts. Fd. Chem. Toxicol., 32:165-171, 1994.

7. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., and Ito, N., Strong promoting effect of Opisthorchis viverrini infection on dimethylnitrosamine-initiated hamster liver. Cancer Lett., 121-125, 1994.

8. Puapairoj, L., Cui, L., Ogawa, K., Aksgi, k., Hasegawa, R., and Ito, N., effect of ethanol on papaquat toxicity in F344 rats. Fd. Chem. Toxicol., 32:379-386, 1994.

9. Hirose, M., Satoh, M., and Ito, N., A storong new antioxidant with potent chemopreventive activity against heterocyclic amine-induced mutagenesis and carcinogenesis: HTHQ. DN&P, 7:167-170, 1994.

10. Takaba, K., Hirose, M., Ogawa, K., Hakoi, K., and Fukusima, S., Modification of N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated urinary bladder carcinogenesis in rats by phytic acid and its salts. Fd. Chem. Toxicol., 32:499-503, 1994.

11. Tanaka, H., Hagiwara, A., Kurata, Y., Ogiso, T., Futakuti, M., and Ito, N., Thirteen-week oral toxicity study of magnesium chloride in B6C3F1mice. Toxicol. Lett., 73:25-32, 1994.

12. Cui, L., Hasegawa, R., Zajdela, F., Puapairoj, P., Shirai, T., and Ito, N., Lack of promoting activity of 7-methoxy-2-nitro-naphtho-[2,1-b]furan (R7000) in a medium-term rat liver bioassay. Cancer Lett., 76:161-166,

13. Shibata, M., Shirai. T., Takahashi, S., Takesada, Y., Iwata, H., Okumura, M., and Fukusima, S., Progressive growth of rat bladder carcinomas after exposure to prolonged uracil-induced urolithiasis. Teratogen. Carcin. Mut., 14:157-168, 1994.

14. Thamavit, W., Pairojkul, C., Tiwawech, D., Shirai, T., and Ito, N., Lack of Promoting effect of proline on bile duct cancer development in dimethylnitrosamine-initiated hamster livers. Teratogen. Carcin. Mut., 14:169-174, 1994.

15. Hirose, M., Hoshiya, T., Akagi, K., Futakuchi, M., and Ito, N., Inhibition of mammary gland carcinogenesis by green tea catechins and other naturally occurring antioxidants in female Sprague-Dawley rats pretreated with 7, 12-dimethylbenz[a]anthracene. Cancer Lett., 83:149-156, 1994.

16. Hasegawa, R., Yoshida, T., Mizogichi, Y., Futakuchi, M., Kim, D,J., Cui, L., and Ito, N., Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital. Cancer Lett., 83:89-95, 1994.

17. Shirai, T., Sano, M., Imaida, K., Takahashi, S., Mori, T., and Ito, N., Duration dependent inducation of invasive prostatic carcinomas with pharmacological dose of testosterone propionate in rats pretreated with 3,2'-dimethyl-4-aminobiphenyl and development of androgen-independent carcinomas after castration. Cancer Lett., 83:111-116, 1994.

18. Yuasa, H., Hirano, K., Kodama, H., Nakanishi, H., Imai, T., Tsuda, H., Imaida, K., and Tatematsu, M., Immunohistochemical demonstoration of intestinal-type alkaline phosphatase in stomach tumors induced by N-metyl-N'-nitro-N-nitrosoguanidine in rats. Jpn. J. Cancer Res., 85:897-903, 1994.

19. Asamoto, M., Takahashi, S., Imaida, K., Shirai, T., and Fukushima, S., Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis. Carcinogenesis, 15:2163-2166, 1994.

20. Shirai, T., Tada, M., Kojima, M., Hasegawa, R., Masui, T., and Ito, N., DNA adducts in target and nontarget tissues of 3,2'-dimethyl-4-aminobiphenyl in rats. Environ. Health Perspect.,

21. Hasegawa, R., Tanaka, H., Tamano, S., Shirai, T., Nagao, M., Sugimura, T., and Ito, N., Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay. Carcinogenesis, 15:2567-2573, 1994.

22. Tamano, S., Hasegawa, R., Hagiwara, A., Nagao, M., Sugimura, T., and Ito, N., Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC), in male F344 rats. Carcinogenesis, 15: 2009-2015, 1994.

23. Hagiwara, A., Tanaka, H., Tamano, S., Imaida, K., Takahashi, S., and Fukushima, S., Inhibiting effects of diethylmaleate or NH4Cl on NaHCO3, but not butylated hydroxyanisole, promotion of urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N- (4-hydroxybutyl)nitrosamine. J. Toxicol. Sci., 19:189-195, 1994.

24. Itoh, M., Pairojkul, C., Thamawit, W., Sithithaworn, P., and Tiwawech, D., Uttaravicien, T., Shirai, T., Ito, N., Association of antibodies to opisthorchis viverrini with hepatobiliary disease in northeastern thailand. Am. J. Trop. Med. Hyg., 51:424-429, 1994.

25. Masui, T., Don, I., Takada, N., Ogawa, K., Shirai, T., and Fukushima, S., P53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Carcinogenesis, 15: 2379-2381, 1994.

26. Ushijima, T., Kakiuchi, H., Makino, H., Hasegawa, R., Ishikawa, Y., Hirai, H., Yazaki, Y., Ito, N., Sugimura, T., and Nagao, M., Infrequent mutation of Ha-ras and P53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Mol. Carcinogenesis, 10:38-44, 1994.

27. Nagao, M., Ushijima, T., Wakabayashi, K., Ochiai, M., Kushida, H., Sugimura, T., Hasegawa, R., Shirai, T., and Ito, N., Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods. Cancer, 74:1063-1069, 1994.

28. Shibata, M-A., Shirai, T., Ogawa, K., Takahashi, S., Wild, C.P., Montesanto, R., Tsuda, H., and Ito, N., DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)- nitrosamine-induced bladder tumors caused by a single exposure to N-methly-N-nitrosourea. Carcinogenesis, 15:2965-2968, 1994. 29. Shirai, T., Imaida, K., Masui, T., Iwasaki, S., Mori, T., Kato, T., and Ito, N., Effects of testosterone, dihydrotestosterone and estrogen on 3,2-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Int. J. Cancer., 57:224-228, 1994.


細菌学講座

1. Motoyama, N., Miwa, T., Suzuki, Y., Okada, H., and Azuma, T., Comparison of somatic mutation frequency among immunoglobulin genes. J. Exp. Med., 179:395-403, 1994

2. Sasaki, N., Hayashizaki, Y., Muramatsu, M., Matsuda, Y., Ando, Y., Kuramoto, T., Serikawa, T., Azuma, T., Naito, A., Agui, T., Yamashita, T., Miyoshi, I., Takeichi, N., and Kasai, N., The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human Wilson disease gene. Biochem. Biophy. Res. Commun., 202:512-518, 1994


生体高分子部門

1. Baranyi, L., Baranyi, K., Yoshida, T., Okada, N., and Okada, H., Partial characterization of a low moleculer weight phagocytosis inhibitory factor obtained from human erythrocyte membranes. Immunobiology, 192:94-105, 1994.

2. Takeuchi, Y., Cosset, F-L., Lachmann, P.J., Okada, H., Weiss, R.A., and Collins, M.K., C-type retroviral inactivation by human complement is determined by both the viral genome and the producer cell. J. Virol., 68:8001-8007, 1994.

3. Matsuo, S., Ichida, S., Takizawa, H., Okada, N., Baranyi, L., Iguchi, A., Morgan, B.P., and Okada, H., In vitro effects of monoclonal antibodies which functionally inhibit complement regulatory proteins in rats. J. Exp. Med., 180:1619-1627, 1994.

4. Baranyi, L., Okada, N., Baranyi, K., Takizawa, H., and Okada, H., Membrane bound complement regulatory activity is decreased on vaccinia virus infected cells. Clin. Exp. Immunol., 98:134-139, 1994.

5. Baranyi, K., Baranyi, L., Yoshida, T., Okada, N., and Okada, H., A low molecular weight phagocytosis inhibitory factor obtained from human erythrocyte membranes specifically downregulates Mac-1 activity on tetradecanoyl phorbol acetate-stimulated monocytic cell line in a Ca2+ dependent manner. J. Immunol., 153:1724-1735, 1994.

6. Baranyi, L., Baranyi, K., Takizawa, H., Okada, N., and Okada, H., Cell surface bound complement regulatory activity is necessary for the in vivo survival of KDH-8 rat hepatoma. Immunology, 82:522-528, 1994.

7. Takizawa, H., Okada, N., and Okada, H., Complement inhibitor of rat cell membrane resembling mouse Crry/p65. J. Immunol., 152:3032-3038, 1994.

8. Funabashi, K., Okada, N., Matsuo, S., Morgan, B.P., and Okada, H., Tissue distribution of complement regulatory membrane proteins in rats. Immunology, 81:444-451, 1994.

9. Sakurada, C., Seno, H., Dohi, N., Takizawa, H., Nonaka, M., Okada, N., and Okada, H., Molecular cloning of the rat complement regulatory protein, 5I2 antigen. Biochem. Biophys. Res. Comm. 198:819-826, 1994.

10. Ichida, S., Yuzawa, Y., Okada, H., Yoshioka, K., and Matsuo, S., Localization of the complement regulatory proteins in the normal human kidney. Kidney Int., 46:89-96, 1994.

11. Kato, K., Shinagawa, N., Hayakawa, T., Takeyama, H., Campbell, W., and Okada, H., Changes in arginine carboxypeptidase (CPR) activity in stressed rats. Pathophysiology, 1:131-136, 1994.


第1内科学講座

1. Kawai, T., Joh, T., Iwata, F., and Itoh, M., Gastric epithelial damage induced by local ishemia-reperfusion with or without exogenous acid. Am. J. Physiol., 266:G263-G270, 1994

2. Okayama, N., Joh, T., Miyamoto, T., Kato, T., and Itoh, M., Role of myosin light-chain kinase and protein kinase C in pepsinogen secretion from guinea pig gastric chief cells in monolayer culture. Dig. Dis. Sci., 39:2547-2557, 1994

3. Okayama, N., Itoh, M., Joh, T., Miyamato, T., Takeuchi, T., and Kato, T., Nicotine stimulates pepsinogen secretion from guinea pig gastric chief cells in monolayer culture. Life Sci., 56:169-177, 1994


第1外科学講座

1. 毛利紀章、水野 勇、山本哲也、四ッ柳智久、青木秀希、Drug carrier としての水酸アパタイト細粒を用いた癌性腹膜炎に対する癌局所免疫化学療法の基礎的検討。DDS(Drug Delivery System), 9:45-49, 1994

2. Kato, K., Shinagawa, N., Hayakawa, T., Takeyama, H., Campbell, W., and Okada, H., Changes in arginine carboxypeptidase(CPR) activity in stressed rats. Pathophysiology, 1:131-136, 1994

3. Mizuno, I., Yamamoto, T., Yotsuyanagi, T., Akamo, Y., Ichino, T., Yasui, T., Kobayashi, K., Taniguchi, M., Nagata, M., Yura, J., Nakamura, S., and Aoki, H., Intraperitoneal administration of lentinan-loaded hydroxyapatite particles as a drug carrier in rats bearing carcinomatous peritonitis. Artificial Organs Today, 3:185-192, 1994

4. Akamo, Y., Mizuno, I., Yotsuyanagi, T., Ichino, T., Tanimoto, N., Yamamoto, T., Yasui, T., Nagata, M., Shinagawa, N., and Yura, J., Lymph node-targeting delivery of adriamycin by liposomal administration into gastric submucosa in rabbits. Recent Advances in Managment of Digestive Cancers(ed. Takahashi, T., Springer-Verlag), 360-362, 1994

5. Zeng, Q.S., Takeyama, H., Kanda, S., and Irie, R.F., Serum preparation and methods for the large-scale production of IgG monoclonal antibody. Hum. Antibod. Hybridomas, 5:75-80, 1994

6. Kanda, S., Takeyama, H., Kikumoto, Y., Morrison, S.L., Morton, D.L., and Irie, R.F., Both VH and VL regions contribute to the antigenicity of anti-idiotypic antibody that mimics melanoma associated ganglioside GM3. Cell Biophys., 24:65-74, 1994


眼科学講座

1. 玉井一司、馬嶋昭生、陳 晏、低温下硝子体手術のぶどう膜循環、術後炎症に及ぼす影響。日本眼科学会雑誌、98:832-836, 1994


耳鼻咽喉科学講座

1. 山田眞幹、高木一平、馬場駿吉、西村 穣、徐放性の抗菌剤(ジベカシン)含有マイクロスフェアの作製とその放出実験の結果について。日本耳鼻咽喉科感染症研究会会誌、12:186-190, 1994


動物実験施設

 1. Miura, T., Yamada, T., Moralejo, D.H., Agui, T., Yamada, J., Serikawa, T., and Matsumoto, K., Chromosomal assignments of genes for rat ceruloplasmin (CP) and metallothionein (MT). Cytogenet. Cell Genet., 65: 119-121, 1994

2. Sakai, T., Agui, T., Miura, M., Yamada, T., and Matsumoto, K., Inheritance of immunoglobulin subclass regulator-1 (lgsr-1) in LEC mutant rats. J. Vet. Med. Sci., 56:883-886, 1994

3. Sakai, T., Agui, T., and Matsumoto, K., Intestinal intraepithelial lymphocytes in LEC mutant rats. Immunol. Lett., 41:185-189, 1994

4. Cai, Y., Yamada, T., Xin, X., Agui, T., and Matsumoto, K., Mapping of the gene for rat endothelin-1 (Et1) to chromosome 17. Mammalian Genom, 5:594, 1994

5. Sasaki, N., Hayashizaki, Y., Muramatsu, M., Matsuda, Y., Ando, Y., Kuramoto, T., Serikawa, T., Azuma, T., Naito, A., Agui, T., Yamashita, T., Miyoshi, I., Takeichi, N., and Kasai, N., The gene responsible for LEC hepatitis, located on rat chromosome 16, is the homolog to the human Wilson disease gene. Biochem. Biophys. Res. Commun., 202:512-518, 1994

6. Sakai, T., Agui, T., and Matsumoto, K., Expression of major histocompatibility complex class but not of CD8 molecules by lectin-stimulated peripheral CD4+ T cells in LEC mutant rats. Cell. Immunol., 158:414-422, 1994

7. Agui, T., Xin, X., Cai, Y., Sakai, T., and Matsumoto, K., Stimalation of interleukin-6 production by endothelin in rat bone marrow-derived stromal cells. Blood, 84:2531-2538, 1994

8. Xin, X., Cai, Y., Chikamori-Aoyama, M., Mori, N., Kishino, Y., and Agui, T., Morphological changes in rat aortic endothelial cell line stimulated by endothelin. Tokushima J. Exp. Med., 41:79-86, 1994