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Ugawa S, Ishida Y, Ueda T, Inoue K, Nagao M, Shimada S. Nafamostat mesilate
reversibly blocks acid-sensing ion channel currents. Biochem Biophys Res Commun.
2007;363:203-8.
Kitamura T, Harada N, Goto E, Tanaka K, Arai M, Shimada S, Okajima K. Activation
of sensory neurons contributes to reduce spinal cord injury in rats.
Neuropharmacology. 2007;52:506-14.
Ugawa S, Inagaki A, Yamamura H, Ueda T, Ishida Y, Kajita K, Shimizu H, Shimada
S. Acid-sensing ion channel-1b in the stereocilia of mammalian cochlear hair
cells. Neuroreport. 2006;17:1235-9.
Shimozawa N, Okajima K, Harada N, Arai M, Ishida Y, Shimada S, Kurihara H,
Nakagata N. Contribution of sensory neurons to sex difference in the development
of stress-induced gastric mucosal injury in mice. Gastroenterology.
2006;131:1826-34.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. A novel spliced variant of the
epithelial Na+ channel delta-subunit in the human brain. Biochem Biophys Res
Commun. 2006;349:317-21.
Nagaki K, Yamamura H, Shimada S, Saito T, Hisanaga S, Taoka M, Isobe T, Ichimura
T. 14-3-3 Mediates phosphorylation-dependent inhibition of the interaction
between the ubiquitin E3 ligase Nedd4-2 and epithelial Na+ channels.
Biochemistry. 2006;45:6733-40.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. Icilin activates the
delta-subunit of the human epithelial Na+ channel. Mol Pharmacol. 2005
;68:1142-1147.
Yamamura H, Ugawa S, Ueda T, Shimada S. Evans blue is a specific antagonist of
the human epithelial Na+ channel delta-subunit. J Pharmacol Exp Ther.
2005;315:965-969.
Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K, Shinkawa T,
Takahashi N, Shimada S, Isobe T. 14-3-3 proteins modulate the expression of
epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2
ubiquitin ligase. J Biol Chem. 2005;280:13187-13194.
Ugawa S, Ueda T, Yamamura H, Shimada S. In situ hybridization evidence for the
coexistence of ASIC and TRPV1 within rat single sensory neurons. Mol Brain Res.
2005;136:125-133.
Okabe K, Kimura H, Okabe J, Kato A, Shimizu H, Ueda T, Shimada S, Ogura Y.
Effect of benzalkonium chloride on transscleral drug delivery. Invest Ophthalmol
Vis Sci. 2005;46:703-708.
Matsunaga N, Ozeki H, Hirabayashi Y, Shimada S, Ogura Y. Histopathologic
evaluation of the internal limiting membrane surgically excised from eyes with
diabetic maculopathy. Retina. 2005; 25:311-316.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. Capsazepine Is a Novel
Activator of the {delta} Subunit of the Human Epithelial Na+ Channel. J Biol
Chem. 2004;279:44483-44489.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. Protons activate the
delta-subunit of the epithelial Na+ channel in humans. J Biol Chem. 2004;
279:12529-12534.
Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S. Functional interaction
between T2R taste receptors and G-protein alpha subunits expressed in taste
receptor cells. J Neurosci, 2003; 23, 7376-7380.
Nishiwaki A, Ueda T, Ugawa S, Shimada S, Ogura Y. Upregulation of P-selectin and
intercellular adhesion molecule-1 after retinal ischemia-reperfusion injury.
Invest Ophthalmol Vis Sci. 2003; 44:4931-5.
Ugawa S, Yamamoto T, Ueda T, Ishida Y, Inagaki A, Nishigaki M, Shimada S.
Amiloride-insensitive currents of the ASIC2a/ASIC2b heteromeric sour-taste
receptor channel. J Neurosci, 2003; 23, 3616-3622.
Imayasu M, Shimada S. Phosphorylation of MAP kinase in corneal epithelial cells
during wound healing. Curr Eye Res. 2003;27:133-41.
Ueda T, Ugawa S, Shimada S. A novel putative M9.2 isoform of V-ATPase expressed
in the nervous system. Neuroreport. 2003; 14: 25-30.
El-Malky M, Maruyama H, Hirabayashi Y, Shimada S, Yoshida A, Amano T, Tominaga
A, Takatsu K, Ohta N. Intraepithelial infiltration of eosinophils and their
contribution to the elimination of adult intestinal nematode, Strongyloides
venezuelensis in mice. Parasitol Int. 2003; 52: 71-79.
Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S.
Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed
in human nociceptors. J Clin Invest. 2002; 110: 1185-1190.
Ishida Y, Ugawa S, Ueda T, Murakami S, Shimada S. Vanilloid receptor subtype-1
(VR1) is specifically localized to taste papillae. Mol Brain Res. 2002; 107:
17-22.
Maruyama H, Hirabayashi Y, el-Malky M, Okamura S, Aoki M, Itagaki T,
Nakamura-Uchiyama F, Nawa Y, Shimada S, Ohta N. Strongyloides venezuelensis:
longitudinal distribution of adult worms in the host intestine is influenced by
mucosal sulfated carbohydrates. Exp Parasitol. 2002; 100: 179-85.
Aihara N, Imamura N, Kimura T, Yamada K, Hida H, Nishino H, Ueda T, Shimada S.
Intracerebral hemorrhage upregulates Na(+)/myo-inositol cotransporter in the rat
brain. Neurosci Lett. 2002; 327: 21-4.
Nozaki M, Ogura Y, Hirabayashi Y, Saishin Y, Shimada S. Enhanced expression of
adhesion molecules of the retinal vascular endothelium in spontaneous diabetic
rats. Ophthalmic Res. 2002; 34: 158-64.
Ueda T, Iwata A, Komatsu H, Aihara N, Yamada K, Ugawa S, Shimada S. Diffuse
brain injury induces local expression of Na(+)/myo-inositol cotransporter in the
rat brain. Mol Brain Res. 2001, 86, 63-69.
Ugawa S, Sunouchi Y, Ueda T, Takahashi E,Saishin Y, Shimada S, Cloning of a
mouse colonic system B 0+ amino acid transporter related to amino acid
absorption in the colon. Am J Physiol, 2001, 281, G365-370.
Ueda H, Takehana K, Eerdunchaolu, Iwasa K, Fujimori O, Shimada S. Electron
microscopic cytochemical studies of anionic sites in the rat spleen. J Vet Med
Sci 2001; 63: 287-91.
Ugawa S, Ueda T, Minami Y, Horimoto M, Shimada S. A single amino acid
substitution in MDEG2 speciffically alters desensitization of the
proton-activated cation current. Neororeport, 2001, 12, 2141-2145.
Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S. Identification of
coding single-nucleotide polymorphisms in human taste receptor genes involving
bitter tasting. Biochem Biophys Res Commun, 2001, 285, 147-151.
Ozeki H, Ogura Y, Hirabayashi Y, Shimada S. Suppression of lens stalk cell
apoptosis by hyaluronic acid leads to faulty separation of the lens vesicle. Exp
Eye Res. 2001;72:63-70.
Ueda T, Ugawa S, Saishin Y, Shimada S. Expression of receptor-activity modifying
protein (RAMPs) mRNAs in the mouse brain. Mol Brain Res 2001,93, 36-45.
Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M. Cloning of a
lymphatic peptide/histidine transporter. Biochem J 2001, 356, 53-60.
Ugawa S, Ueda T, Takahashi E, Hirabayashi Y, Yoneda T, Komai S, Shimada S.
Cloning and functional expression of ASIC-b2, a splice variant of ASIC-b, that
alters pH-sensitivity of acid-sensing ion channel complex. Neuroreport 2001, 12,
2865-2869.
Nishiwaki A, Asai K, Tada T, Ueda T, Shimada S, Ogura Y, Kato T. Expression of
glia maturation factor during retinal development in the rat. Mol Brain Res.
2000;95:103-9.
Ozeki H, Ogura Y, Hirabayashi Y, Shimada S. Apoptosis is associated with
formation and persistence of the embryonic fissure. Current Eye Research, 2000,
20, 367-372.
Saishin Y, Ishikawa R, Ugawa S, Guo W, Ueda T, Morimura H, Kohama K, Shimizu H,
Tano Y, Shimada S. Retinal fascin: functional nature, subcellular distribution,
and chromosomal localization. Invest Ophthalmol Vis Sci. 2000; 41:2087-95.
Horimoto M, Sasaki Y, Ugawa S, Wada S, Toyama T, Iyoda K, Yakushijin T, Minami
Y, Ito T, Hijioka T, Eguchi A, Nakanishi M, Shimada S, Tohyama M, Hayashi N,
Hori M. A novel strategy for cancer therapy by mutated mammalian degenerin gene
transfer. Cancer Gene Ther, 2000, 7:1341-1347.
Mizuno N, Kitayama S, Saishin Y, Shimada S, Morita K, Mitsuhata C, Kurihara H,
Dohi T. Molecular cloning and characterization of rat trp homologues from brain.
Mol Brain Res. 1999 Jan 22;64(1):41-51.
Sakata K, Shimada S, Yamashita T, Inoue K, Tohyama M. Cloning of a bovine orphan
transporter and its short splicing variant FEBS Lett 1999, 443, 267-270.
Nishimura M, Sato K, Shimada S, Tohyama M, Expression of norepinephrine and
serotonin transporter mRNAs in the rat superior cervical ganglion. Mol Brain Res,
1999 , 67, 82-6.
Ito Y, Fujita M, Shimada S, Watanabe Y, Okada T, Kusuoka H, Tohyama M, Nishimura
T. Comparison between the decrease of dopamine transporter and that of L-DOPA
uptake for detection of early to advanced stage of Parkinson's disease in animal
models. Synapse, 1999, 31, 178-85.
Kitamura, H., Yamauchi, A., Sugiura, T., Matsuoka, Y., Horio, M., Tohyama, M.,
Shimada, S., Imai, E., Hori, M. Inhibition of myo-inositol transport causes
acute renal failure with selective medullary injury in the rat. Kidney Int,
1998,53, 146-153.
Okada, T., Fujita, M., Shimada, S., Sato, K., Schloss, P., Watanabe, Y., Itoh,
Y., Tohyama, M., Nishimura, T., Assessment of affinities of beta-CIT,
beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in
cell lines. Nucl Med Biol 1998; 25: 53-58
Nonaka, M., Kohmura, E., Yamashita,T., Shimada,S., Tanaka,K., Yoshimine,T.,
Tohyama,M., Hayakawa, T. Increased transcription of glutamate-aspartate
transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure.
Mol Brain Res 1998; 55: 54-60
Okada T, Shimada S, Sato K, Kotake Y, Kawai H, Ohta S, Tohyama M, Nishimura T,
Tetrahydropapaveroline and its derivatives inhibit dopamine uptake through
dopamine transporter expressed in HEK293 cells. Neurosci Res 1998; 30:87-90
Nishimura M, Sato K, Okada T, Yoshiya I, Schloss P, Shimada S, Tohyama M
Ketamine inhibits monoamine transporters expressed in human embryonic kidney 293
cells. Anesthesiology 1998; 88:768-774
Nishimura M, Sato K, Okada T, Schloss P, Shimada S, Tohyama M MK-801 blocks
monoamine transporters expressed in HEK cells. FEBS Lett 1998;423, 376-380
Ugawa S., Minami Y, Guo W, Saishin Y, Takatsuji K, Yamamoto T, Tohyama M,
Shimada S. Receptor that leaves a sour taste in the mouth. Nature, 1998, 395,
555-556.
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