研究業績
Ugawa S, Ishida Y, Ueda T, Inoue K, Nagao M, Shimada S.
Nafamostat mesilate reversibly blocks acid-sensing ion channel
currents. Biochem Biophys Res Commun. 2007;363:203-8.
Kitamura T, Harada N, Goto E, Tanaka K, Arai M, Shimada S, Okajima K.
Activation of sensory neurons contributes to reduce spinal cord injury
in rats. Neuropharmacology. 2007;52:506-14.
Ugawa S, Inagaki A, Yamamura H, Ueda T, Ishida Y, Kajita K, Shimizu H,
Shimada S. Acid-sensing ion channel-1b in the stereocilia of mammalian
cochlear hair cells. Neuroreport. 2006;17:1235-9.
Shimozawa N, Okajima K, Harada N, Arai M, Ishida Y, Shimada S, Kurihara
H, Nakagata N. Contribution of sensory neurons to sex difference in the
development of stress-induced gastric mucosal injury in mice.
Gastroenterology. 2006;131:1826-34.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. A novel spliced
variant of the epithelial Na+ channel delta-subunit in the human
brain. Biochem Biophys Res Commun. 2006;349:317-21.
Nagaki K, Yamamura H, Shimada S, Saito T, Hisanaga S, Taoka M, Isobe T,
Ichimura T. 14-3-3 Mediates phosphorylation-dependent inhibition
of the interaction between the ubiquitin E3 ligase Nedd4-2 and
epithelial Na+ channels. Biochemistry. 2006;45:6733-40.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. Icilin
activates the delta-subunit of the human epithelial Na+ channel.
Mol Pharmacol. 2005 ;68:1142-1147.
Yamamura H, Ugawa S, Ueda T, Shimada S. Evans blue is a specific
antagonist of the human epithelial Na+ channel delta-subunit. J
Pharmacol Exp Ther. 2005;315:965-969.
Ichimura T, Yamamura H, Sasamoto K, Tominaga Y, Taoka M, Kakiuchi K,
Shinkawa T, Takahashi N, Shimada S, Isobe T. 14-3-3 proteins
modulate the expression of epithelial Na+ channels by
phosphorylation-dependent interaction with Nedd4-2 ubiquitin
ligase. J Biol Chem. 2005;280:13187-13194.
Ugawa S, Ueda T, Yamamura H, Shimada S. In situ
hybridization evidence for the coexistence of ASIC and TRPV1 within rat
single sensory neurons. Mol Brain Res. 2005;136:125-133.
Okabe K, Kimura H, Okabe J, Kato A, Shimizu H, Ueda T, Shimada S, Ogura
Y. Effect of benzalkonium chloride on transscleral drug
delivery.
Invest Ophthalmol Vis Sci. 2005;46:703-708.
Matsunaga N, Ozeki H, Hirabayashi Y, Shimada S, Ogura Y.
Histopathologic evaluation of the internal limiting membrane surgically
excised from eyes with diabetic maculopathy. Retina. 2005;
25:311-316.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. Capsazepine Is a
Novel Activator of the {delta} Subunit of the Human Epithelial Na+
Channel. J Biol Chem. 2004;279:44483-44489.
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S. Protons activate
the delta-subunit of the epithelial Na+ channel in humans. J Biol Chem.
2004; 279:12529-12534.
Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S. Functional
interaction between T2R taste receptors and G-protein alpha subunits
expressed in taste receptor cells. J Neurosci, 2003; 23, 7376-7380.
Nishiwaki A, Ueda T, Ugawa S, Shimada S, Ogura Y. Upregulation of
P-selectin and intercellular adhesion molecule-1 after retinal
ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2003;
44:4931-5.
Ugawa S, Yamamoto T, Ueda T, Ishida Y, Inagaki A, Nishigaki M,
Shimada S. Amiloride-insensitive currents of the ASIC2a/ASIC2b
heteromeric sour-taste receptor channel. J Neurosci, 2003; 23,
3616-3622.
Imayasu M, Shimada S. Phosphorylation of MAP kinase
in corneal epithelial cells during wound healing. Curr Eye Res.
2003;27:133-41.
Ueda T, Ugawa S, Shimada S. A novel putative M9.2 isoform of V-ATPase
expressed in the nervous system. Neuroreport. 2003; 14: 25-30.
El-Malky M, Maruyama H, Hirabayashi Y, Shimada S, Yoshida A, Amano T,
Tominaga A, Takatsu K, Ohta N. Intraepithelial infiltration of
eosinophils and their contribution to the elimination of adult
intestinal nematode, Strongyloides venezuelensis in mice. Parasitol
Int. 2003; 52: 71-79.
Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S.
Amiloride-blockable acid-sensing ion channels are leading acid sensors
expressed in human nociceptors. J Clin Invest. 2002; 110: 1185-1190.
Ishida Y, Ugawa S, Ueda T, Murakami S, Shimada S. Vanilloid receptor
subtype-1 (VR1) is specifically localized to taste papillae. Mol Brain
Res. 2002; 107: 17-22.
Maruyama H, Hirabayashi Y, el-Malky M, Okamura S, Aoki M, Itagaki T,
Nakamura-Uchiyama F, Nawa Y, Shimada S, Ohta N. Strongyloides
venezuelensis: longitudinal distribution of adult worms in the host
intestine is influenced by mucosal sulfated carbohydrates. Exp
Parasitol. 2002; 100: 179-85.
Aihara N, Imamura N, Kimura T, Yamada K, Hida H, Nishino H, Ueda T,
Shimada S. Intracerebral hemorrhage upregulates Na(+)/myo-inositol
cotransporter in the rat brain. Neurosci Lett. 2002; 327: 21-4.
Nozaki M, Ogura Y, Hirabayashi Y, Saishin Y, Shimada S. Enhanced
expression of adhesion molecules of the retinal vascular endothelium in
spontaneous diabetic rats. Ophthalmic Res. 2002; 34: 158-64.
Ueda T, Iwata A, Komatsu H, Aihara N, Yamada K, Ugawa S, Shimada S.
Diffuse brain injury induces local expression of Na(+)/myo-inositol
cotransporter in the rat brain. Mol Brain Res. 2001, 86, 63-69.
Ugawa S, Sunouchi Y, Ueda T, Takahashi E,Saishin Y, Shimada S, Cloning
of a mouse colonic system B 0+ amino acid transporter related to amino
acid absorption in the colon. Am J Physiol, 2001, 281, G365-370.
Ueda H, Takehana K, Eerdunchaolu, Iwasa K, Fujimori O, Shimada S.
Electron microscopic cytochemical studies of anionic sites in the rat
spleen. J Vet Med Sci 2001; 63: 287-91.
Ugawa S, Ueda T, Minami Y, Horimoto M, Shimada S. A single amino acid
substitution in MDEG2 speciffically alters desensitization of the
proton-activated cation current. Neororeport, 2001, 12, 2141-2145.
Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S.
Identification of coding single-nucleotide polymorphisms in human taste
receptor genes involving bitter tasting. Biochem Biophys Res
Commun, 2001, 285, 147-151.
Ozeki H, Ogura Y, Hirabayashi Y, Shimada S. Suppression of lens stalk
cell apoptosis by hyaluronic acid leads to faulty separation of the
lens vesicle. Exp Eye Res. 2001;72:63-70.
Ueda T, Ugawa S, Saishin Y, Shimada S. Expression of
receptor-activity modifying protein (RAMPs) mRNAs in the mouse brain.
Mol Brain Res 2001,93, 36-45.
Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M.
Cloning of a lymphatic peptide/histidine transporter. Biochem J
2001, 356, 53-60.
Ugawa S, Ueda T, Takahashi E, Hirabayashi Y, Yoneda T, Komai S, Shimada
S. Cloning and functional expression of ASIC-b2, a splice variant
of ASIC-b, that alters pH-sensitivity of acid-sensing ion channel
complex. Neuroreport 2001, 12, 2865-2869.
Nishiwaki A, Asai K, Tada T, Ueda T, Shimada S, Ogura Y, Kato T.
Expression of glia maturation factor during retinal development in the
rat. Mol Brain Res. 2000;95:103-9.
Ozeki H, Ogura Y, Hirabayashi Y, Shimada S. Apoptosis is
associated with formation and persistence of the embryonic
fissure. Current Eye Research, 2000, 20, 367-372.
Saishin Y, Ishikawa R, Ugawa S, Guo W, Ueda T, Morimura H, Kohama K,
Shimizu H, Tano Y, Shimada S. Retinal fascin: functional nature,
subcellular distribution, and chromosomal localization. Invest
Ophthalmol Vis Sci. 2000; 41:2087-95.
Horimoto M, Sasaki Y, Ugawa S, Wada S, Toyama T, Iyoda K, Yakushijin T,
Minami Y, Ito T, Hijioka T, Eguchi A, Nakanishi M, Shimada S, Tohyama
M, Hayashi N, Hori M. A novel strategy for cancer therapy by
mutated mammalian degenerin gene transfer. Cancer Gene Ther, 2000,
7:1341-1347.
Mizuno N, Kitayama S, Saishin Y, Shimada S, Morita K, Mitsuhata C,
Kurihara H, Dohi T. Molecular cloning and characterization of rat trp
homologues from brain. Mol Brain Res. 1999 Jan 22;64(1):41-51.
Sakata K, Shimada S, Yamashita T, Inoue K, Tohyama M. Cloning of a
bovine orphan transporter and its short splicing variant FEBS Lett
1999, 443, 267-270.
Nishimura M, Sato K, Shimada S, Tohyama M, Expression of
norepinephrine and serotonin transporter mRNAs in the rat superior
cervical ganglion. Mol Brain Res, 1999 , 67, 82-6.
Ito Y, Fujita M, Shimada S, Watanabe Y, Okada T, Kusuoka H, Tohyama M,
Nishimura T. Comparison between the decrease of dopamine
transporter and that of L-DOPA uptake for detection of early to
advanced stage of Parkinson's disease in animal models. Synapse, 1999,
31, 178-85.
Kitamura, H., Yamauchi, A., Sugiura, T., Matsuoka, Y., Horio, M.,
Tohyama, M., Shimada, S., Imai, E., Hori, M. Inhibition of
myo-inositol transport causes acute renal failure with selective
medullary injury in the rat. Kidney Int, 1998,53, 146-153.
Okada, T., Fujita, M., Shimada, S., Sato, K., Schloss, P., Watanabe,
Y., Itoh, Y., Tohyama, M., Nishimura, T., Assessment of
affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine
transporters permanently expressed in cell lines. Nucl Med Biol
1998; 25: 53-58
Nonaka, M., Kohmura, E., Yamashita,T., Shimada,S., Tanaka,K.,
Yoshimine,T., Tohyama,M., Hayakawa, T. Increased transcription of
glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic
acid-induced limbic seizure. Mol Brain Res 1998; 55: 54-60
Okada T, Shimada S, Sato K, Kotake Y, Kawai H, Ohta S, Tohyama M,
Nishimura T, Tetrahydropapaveroline and its derivatives inhibit
dopamine uptake through dopamine transporter expressed in HEK293 cells.
Neurosci Res 1998; 30:87-90
Nishimura M, Sato K, Okada T, Yoshiya I, Schloss P, Shimada S, Tohyama
M Ketamine inhibits monoamine transporters expressed in human embryonic
kidney 293 cells. Anesthesiology 1998; 88:768-774
Nishimura M, Sato K, Okada T, Schloss P, Shimada S, Tohyama M MK-801
blocks monoamine transporters expressed in HEK cells. FEBS Lett
1998;423, 376-380
Ugawa S., Minami Y, Guo W, Saishin Y, Takatsuji K, Yamamoto T,
Tohyama M, Shimada S. Receptor that leaves a sour taste in the
mouth. Nature, 1998, 395, 555-556.